Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Brazilië stelt gebied groter dan Nederland open voor goudwinning
Laan-Luijkx, Ingrid van der - \ 2017
Considering healthiness promotes healthier choices but modulates medial prefrontal cortex differently in children compared with adults
Meer, Floor van; Laan, Laura N. van der; Viergever, Max A. ; Adan, Roger A.H. ; Smeets, Paul A.M. - \ 2017
NeuroImage 159 (2017). - ISSN 1053-8119 - p. 325 - 333.
Children - Decision making - Development - fMRI - Food choice
Childhood obesity is a rising problem worldwide mainly caused by overconsumption, which is driven by food choices. In adults, food choices are based on a value signal encoded in the medial prefrontal cortex (mPFC). This signal is modulated by the dorsolateral prefrontal cortex (dlPFC), which is involved in self-control. We aimed to examine the neural correlates of food choice in children, and how considering healthiness affects neural activity and choice behavior. 24 children and 28 adults performed a food choice task while being scanned with fMRI and provided health and taste ratings of the foods afterwards. During the choice task participants considered either the healthiness or tastiness of the food or chose naturally. Health rating was a positive predictor of choice in adults, but a negative predictor in children. Children had weaker dlPFC activation than adults during yes vs. no independent of health or taste condition. Both children and adults made healthier choices when considering healthiness. Taste rating modulated mPFC activation in both children and adults. When considering the healthiness, health rating positively modulated mPFC activation in adults, but negatively in children. Considering the healthiness increased connectivity between dlPFC and mPFC in adults, but not in children. In conclusion, considering healthiness can promote healthier choices in both children and adults, but is accompanied by an opposing pattern of brain activation in the mPFC. Since the absolute number of healthy choices remained lower in children, this suggests that children may not yet be geared to modify their choices away from their natural tendency to choose unhealthy tasty foods. Thus, this study suggests that it may be promising to develop interventions that increase children's preference for healthy food, for example by increasing the habitual consumption of healthy foods from a young age.
The CarbonTracker Data Assimilation Shell (CTDAS) v1.0 : Implementation and global carbon balance 2001-2015
Laan-Luijkx, Ingrid T. Van Der; Velde, Ivar R. Van Der; Veen, Emma Van Der; Tsuruta, Aki ; Stanislawska, Karolina ; Babenhauserheide, Arne ; Fang Zhang, Hui ; Liu, Yu ; He, Wei ; Chen, Huilin ; Masarie, Kenneth A. ; Krol, Maarten C. ; Peters, Wouter - \ 2017
Geoscientific Model Development 10 (2017)7. - ISSN 1991-959X - p. 2785 - 2800.
Data assimilation systems are used increasingly to constrain the budgets of reactive and long-lived gases measured in the atmosphere. Each trace gas has its own lifetime, dominant sources and sinks, and observational network (from flask sampling and in situ measurements to space-based remote sensing) and therefore comes with its own optimal configuration of the data assimilation. The CarbonTracker Europe data assimilation system for CO2 estimates global carbon sources and sinks, and updates are released annually and used in carbon cycle studies. CarbonTracker Europe simulations are performed using the new modular implementation of the data assimilation system: The CarbonTracker Data Assimilation Shell (CTDAS). Here, we present and document this redesign of the data assimilation code that forms the heart of CarbonTracker, specifically meant to enable easy extension and modification of the data assimilation system. This paper also presents the setup of the latest version of CarbonTracker Europe (CTE2016), including the use of the gridded state vector, and shows the resulting carbon flux estimates. We present the distribution of the carbon sinks over the hemispheres and between the land biosphere and the oceans. We show that with equal fossil fuel emissions, 2015 has a higher atmospheric CO2 growth rate compared to 2014, due to reduced net land carbon uptake in later year. The European carbon sink is especially present in the forests, and the average average net uptake over 2001-2015 was 0:17±0:11 PgCyr-1 with reductions to zero during drought years. Finally, we also demonstrate the versatility of CTDAS by presenting an overview of the wide range of applications for which it has been used so far.
Global methane emission estimates for 2000-2012 from CarbonTracker Europe-CH4 v1.0
Tsuruta, Aki ; Aalto, Tuula ; Backman, Leif ; Hakkarainen, Janne ; Laan-Luijkx, Ingrid T. Van Der; Krol, Maarten C. ; Spahni, Renato ; Houweling, Sander ; Laine, Marko ; Dlugokencky, Ed ; Gomez-Pelaez, Angel J. ; Schoot, Marcel Van Der; Langenfelds, Ray ; Ellul, Raymond ; Arduini, Jgor ; Apadula, Francesco ; Gerbig, Christoph ; Feist, D.G. ; Kivi, Rigel ; Yoshida, Yukio ; Peters, Wouter - \ 2017
Geoscientific Model Development 10 (2017)3. - ISSN 1991-959X - p. 1261 - 1289.

We present a global distribution of surface methane (CH4) emission estimates for 2000-2012 derived using the CarbonTracker Europe-CH4 (CTE-CH4) data assimilation system. In CTE-CH4, anthropogenic and biospheric CH4 emissions are simultaneously estimated based on constraints of global atmospheric in situ CH4 observations. The system was configured to either estimate only anthropogenic or biospheric sources per region, or to estimate both categories simultaneously. The latter increased the number of optimizable parameters from 62 to 78. In addition, the differences between two numerical schemes available to perform turbulent vertical mixing in the atmospheric transport model TM5 were examined. Together, the system configurations encompass important axes of uncertainty in inversions and allow us to examine the robustness of the flux estimates. The posterior emission estimates are further evaluated by comparing simulated atmospheric CH4 to surface in situ observations, vertical profiles of CH4 made by aircraft, remotely sensed dry-air total column-averaged mole fraction (XCH4) from the Total Carbon Column Observing Network (TCCON), and XCH4 from the Greenhouse gases Observing Satellite (GOSAT). The evaluation with non-assimilated observations shows that posterior XCH4 is better matched with the retrievals when the vertical mixing scheme with faster interhemispheric exchange is used. Estimated posterior mean total global emissions during 2000-2012 are 516 ± 51 Tg CH4 yr-1, with an increase of 18 Tg CH4 yr-1 from 2000-2006 to 2007-2012. The increase is mainly driven by an increase in emissions from South American temperate, Asian temperate and Asian tropical TransCom regions. In addition, the increase is hardly sensitive to different model configurations ( < 2 Tg CH4 yr-1 difference), and much smaller than suggested by EDGAR v4.2 FT2010 inventory (33 Tg CH4 yr-1), which was used for prior anthropogenic emission estimates. The result is in good agreement with other published estimates from inverse modelling studies (16-20 Tg CH4 yr-1). However, this study could not conclusively separate a small trend in biospheric emissions (-5 to +6.9 Tg CH4 yr-1) from the much larger trend in anthropogenic emissions (15-27 Tg CH4 yr-1). Finally, we find that the global and North American CH4 balance could be closed over this time period without the previously suggested need to strongly increase anthropogenic CH4 emissions in the United States. With further developments, especially on the treatment of the atmospheric CH4 sink, we expect the data assimilation system presented here will be able to contribute to the ongoing interpretation of changes in this important greenhouse gas budget.

Goal-Directed Visual Attention Drives Health Goal Priming: An Eye-Tracking Experiment
Laan, Laura N. van der; Papies, E.K. ; Hooge, I.T.C. ; Smeets, P.A.M. - \ 2017
Health Psychology 36 (2017)1. - ISSN 0278-6133 - p. 82 - 90.
Objective: Several lab and field experiments have shown that goal priming interventions can be highly effective in promoting healthy food choices. Less is known, however, about the mechanisms by which goal priming affects food choice. This experiment tested the hypothesis that goal priming affects
food choices through changes in visual attention. Specifically, it was hypothesized that priming with the dieting goal steers attention toward goal-relevant, low energy food products, which, in turn, increases the likelihood of choosing these products. Methods: In this eye-tracking experiment, 125 participants chose between high and low energy food products in a realistic online supermarket task while their eye movements were recorded with an eye-tracker. One group was primed with a health and dieting goal, a second group was exposed to a control prime, and a third group was exposed to no prime at all. Results: The health goal prime increased low energy food choices
and decreased high energy food choices. Furthermore, the health goal prime resulted in proportionally longer total dwell times on low energy food products, and this effect mediated the goal priming effect on choices. Conclusions: The findings suggest that the effect of priming on consumer choice may originate from an increase in attention for prime-congruent items. This study
supports the effectiveness of health goal priming interventions in promoting healthy eating and opens up directions for research on other behavioral interventions that steer attention toward healthy foods.
Prediction of the carcinogenic potential of human pharmaceuticals using repeated dose toxicity data and their pharmacological properties
Laan, Jan Willem van der; Buitenhuis, Wenny H.W. ; Wagenaar, Laura ; Soffers, Ans E.M.F. ; Someren, Eugene P. van; Krul, Cyrille A.M. ; Woutersen, Ruud A. - \ 2016
Frontiers in Medicine 3 (2016)OCT. - ISSN 2296-858X
Carcinogenicity - Histopathology - Human pharmaceuticals - Pharmacology - Predictivity

In an exercise designed to reduce animal use, we analyzed the results of rat subchronic toxicity studies from 289 pharmaceutical compounds with the aim to predict the tumor outcome of carcinogenicity studies in this species. The results were obtained from the assessment reports available at the Medicines Evaluation Board of the Netherlands for 289 pharmaceutical compounds that had been shown to be non-genotoxic. One hundred forty-three of the 239 compounds not inducing putative preneoplastic lesions in the subchronic study did not induce tumors in the carcinogenicity study [true negatives (TNs)], whereas 96 compounds were categorized as false negatives (FNs) because tumors were observed in the carcinogenicity study. Of the remaining 50 compounds, 31 showed preneoplastic lesions in the subchronic study and tumors in the carcinogenicity study [true positives (TPs)], and 19 only showed preneoplastic lesions in subchronic studies but no tumors in the carcinogenicity study [false positives (FPs)]. In addition, we then re-assessed the prediction of the tumor outcome by integrating the pharmacological properties of these compounds. These pharmacological properties were evaluated with respect to the presence or absence of a direct or indirect proliferative action. We found support for the absence of cellular proliferation for 204 compounds (TN). For 67 compounds, the presence of cellular hyperplasia as evidence for proliferative action could be found (TP). Therefore, this approach resulted in an ability to predict non-carcinogens at a success rate of 92% and the ability to detect carcinogens at 98%. The combined evaluation of pharmacological and histopathological endpoints eventually led to only 18 unknown outcomes (17 categorized as FN and 1 as FP), thereby enhancing both the negative and positive predictivity of an evaluation based upon histopathological evaluation only. The data show the added value of a consideration of the pharmacological properties of compounds in relation to potential class effects, both in the negative and positive direction. A high negative and a high positive predictivity will both result in waiving the need for conducting 2-year rat carcinogenicity studies, if this is accepted by Regulatory Authorities, which will save large numbers of animals and reduce drug development costs and time.

Nocturnal activity as indicator of adaptability of dogs to a shelter environment – preliminary results
Laan, Janneke E. van der; Wal, Annika S. van der; Bril, Lisanne M. ; Borg, J.A.M. van der - \ 2016
Wat gaat de Amazone doen? : laser, satelliet en meetlint vertellen hoe het regenwoud klimaatverandering doorstaat
Laan-Luijkx, Ingrid van der - \ 2016

Het is vaker droog dan voorheen in de Amazone, en dan produceert ’s werelds grootste oerwoud enorme hoeveelheden CO2. Mogelijk gaat het bos er zelfs aan onderdoor, met grote gevolgen voor het klimaat. Wageningse onderzoekers zien zowel tekenen van stress als een verrassend grote veerkracht.

Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Barban, Nicola ; Jansen, Rick ; Vlaming, Ronald de; Vaez, Ahmad ; Mandemakers, Jornt J. ; Tropf, Felix C. ; Shen, Xia ; Wilson, James F. ; Chasman, Daniel I. ; Nolte, Ilja M. ; Tragante, Vinicius ; Laan, Sander W. van der; Perry, John R.B. ; Kong, Augustine ; Ahluwalia, Tarunveer S. ; Albrecht, Eva ; Yerges-Armstrong, Laura ; Atzmon, Gil ; Auro, Kirsi ; Ayers, Kristin ; Bakshi, Andrew ; Ben-Avraham, Danny ; Berger, Klaus ; Bergman, Aviv ; Bertram, Lars ; Bielak, Lawrence F. ; Bjornsdottir, Gyda ; Bonder, Marc Jan ; Broer, Linda ; Bui, Minh ; Barbieri, Caterina ; Cavadino, Alana ; Chavarro, Jorge E. ; Turman, Constance ; Concas, Maria Pina ; Cordell, Heather J. ; Davies, Gail ; Eibich, Peter ; Eriksson, Nicholas ; Esko, Tõnu ; Eriksson, Joel ; Falahi, Fahimeh ; Felix, Janine F. ; Fontana, Mark Alan ; Franke, Lude ; Gandin, Ilaria ; Gaskins, Audrey J. ; Gieger, Christian ; Gunderson, Erica P. ; Guo, Xiuqing ; Hayward, Caroline ; He, Chunyan ; Hofer, Edith ; Huang, Hongyan ; Joshi, Peter K. ; Kanoni, Stavroula ; Karlsson, Robert ; Kiechl, Stefan ; Kifley, Annette ; Kluttig, Alexander ; Kraft, Peter ; Lagou, Vasiliki ; Lecoeur, Cecile ; Lahti, Jari ; Li-Gao, Ruifang ; Lind, Penelope A. ; Liu, Tian ; Makalic, Enes ; Mamasoula, Crysovalanto ; Matteson, Lindsay ; Mbarek, Hamdi ; McArdle, Patrick F. ; McMahon, George ; Meddens, S.F.W. ; Mihailov, Evelin ; Miller, Mike ; Missmer, Stacey A. ; Monnereau, Claire ; Most, Peter J. van der; Myhre, Ronny ; Nalls, Mike A. ; Nutile, Teresa ; Kalafati, Ioanna Panagiota ; Porcu, Eleonora ; Prokopenko, Inga ; Rajan, Kumar B. ; Rich-Edwards, Janet ; Rietveld, Cornelius A. ; Robino, Antonietta ; Rose, Lynda M. ; Rueedi, Rico ; Ryan, Kathleen A. ; Saba, Yasaman ; Schmidt, Daniel ; Smith, Jennifer A. ; Stolk, Lisette ; Streeten, Elizabeth ; Tönjes, Anke ; Thorleifsson, Gudmar ; Ulivi, Sheila ; Wedenoja, Juho ; Wellmann, Juergen ; Willeit, Peter ; Yao, Jie ; Yengo, Loic ; Zhao, Jing Hua ; Zhao, Wei ; Zhernakova, Daria V. ; Amin, Najaf ; Andrews, Howard ; Balkau, Beverley ; Barzilai, Nir ; Bergmann, Sven ; Biino, Ginevra ; Bisgaard, Hans ; Bønnelykke, Klaus ; Boomsma, Dorret I. ; Buring, Julie E. ; Campbell, Harry ; Cappellani, Stefania ; Ciullo, Marina ; Cox, Simon R. ; Cucca, Francesco ; Toniolo, Daniela ; Davey-Smith, George ; Deary, Ian J. ; Dedoussis, George ; Deloukas, Panos ; Duijn, Cornelia M. van; Geus, Eco J.C. de; Eriksson, Johan G. ; Evans, Denis A. ; Faul, Jessica D. ; Sala, Cinzia Felicita ; Froguel, Philippe ; Gasparini, Paolo ; Girotto, Giorgia ; Grabe, Hans-Jörgen ; Greiser, Karin Halina ; Groenen, Patrick J.F. ; Haan, Hugoline G. de; Haerting, Johannes ; Harris, Tamara B. ; Heath, Andrew C. ; Heikkilä, Kauko ; Hofman, Albert ; Homuth, Georg ; Holliday, Elizabeth G. ; Hopper, John ; Hyppönen, Elina ; Jacobsson, Bo ; Jaddoe, Vincent W.V. ; Johannesson, Magnus ; Jugessur, Astanand ; Kähönen, Mika ; Kajantie, Eero ; Kardia, Sharon L.R. ; Keavney, Bernard ; Kolcic, Ivana ; Koponen, Päivikki ; Kovacs, Peter ; Kronenberg, Florian ; Kutalik, Zoltan ; Bianca, Martina la; Lachance, Genevieve ; Iacono, William G. ; Lai, Sandra ; Lehtimäki, Terho ; Liewald, David C. ; Lindgren, Cecilia M. ; Liu, Yongmei ; Luben, Robert ; Lucht, Michael ; Luoto, Riitta ; Magnus, Per ; Magnusson, Patrik K.E. ; Martin, Nicholas G. ; McGue, Matt ; McQuillan, Ruth ; Medland, Sarah E. ; Meisinger, Christa ; Mellström, Dan ; Metspalu, Andres ; Traglia, Michela ; Milani, Lili ; Mitchell, Paul ; Montgomery, Grant W. ; Mook-Kanamori, Dennis ; Mutsert, Renée de; Nohr, Ellen A. ; Ohlsson, Claes ; Olsen, Jørn ; Ong, Ken K. ; Paternoster, Lavinia ; Pattie, Alison ; Penninx, Brenda W.J.H. ; Perola, Markus ; Peyser, Patricia A. ; Pirastu, Mario ; Polasek, Ozren ; Power, Chris ; Kaprio, Jaakko ; Raffel, Leslie J. ; Räikkönen, Katri ; Raitakari, Olli ; Ridker, Paul M. ; Ring, Susan M. ; Roll, Kathryn ; Rudan, Igor ; Ruggiero, Daniela ; Rujescu, Dan ; Salomaa, Veikko ; Schlessinger, David ; Schmidt, Helena ; Schmidt, Reinhold ; Schupf, Nicole ; Smit, Johannes ; Sorice, Rossella ; Spector, Tim D. ; Starr, John M. ; Stöckl, Doris ; Strauch, Konstantin ; Stumvoll, Michael ; Swertz, Morris A. ; Thorsteinsdottir, Unnur ; Thurik, A.R. ; Timpson, Nicholas J. ; Tung, Joyce Y. ; Uitterlinden, André G. ; Vaccargiu, Simona ; Viikari, Jorma ; Vitart, Veronique ; Völzke, Henry ; Vollenweider, Peter ; Vuckovic, Dragana ; Waage, Johannes ; Wagner, Gert G. ; Wang, Jie Jin ; Wareham, Nicholas J. ; Weir, David R. ; Willemsen, Gonneke ; Willeit, Johann ; Wright, Alan F. ; Zondervan, Krina T. ; Stefansson, Kari ; Krueger, Robert F. ; Lee, James J. ; Benjamin, Daniel J. ; Cesarini, David ; Koellinger, Philipp D. ; Hoed, Marcel den; Snieder, Harold ; Mills, Melinda C. - \ 2016
Nature Genetics 48 (2016)12. - ISSN 1061-4036 - p. 1462 - 1472.
The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
Developmental differences in the brain response to unhealthy food cues : An fMRI study of children and adults
Meer, Floor van; Laan, Laura N. van der; Charbonnier, Lisette ; Viergever, Max A. ; Adan, Roger A.H. ; Smeets, Paul A.M. - \ 2016
American Journal of Clinical Nutrition 104 (2016)6. - ISSN 0002-9165 - p. 1515 - 1522.
Childhood obesity - Children - FMRI - Food viewing - Healthy food

Background: Food cues are omnipresent and may trigger overconsumption. In the past 2 decades, the prevalence of childhood obesity has increased dramatically. Because children's brains are still developing, especially in areas important for inhibition, children may be more susceptible than adults to tempting food cues. Objective: We examined potential developmental differences in children's and adults' responses to food cues to determine how these responses relate to weight status. Design: We included 27 children aged 10-12 y and 32 adults aged 32-52 y. Functional magnetic resonance imaging data were acquired during a food-viewing task in which unhealthy and healthy food pictures were presented. Results: Children had a stronger activation in the left precentral gyrus than did adults in response to unhealthy compared with healthy foods. In children, unhealthy foods elicited stronger activation in the right inferior temporal and middle occipital gyri, left precentral gyrus, bilateral opercular part of the inferior frontal gyrus, left hippocampus, and left middle frontal gyrus. Adults had stronger activation in the bilateral middle occipital gyrus and the right calcarine sulcus for unhealthy compared with healthy foods. Children with a higher body mass index (BMI) had lower activation in the bilateral dorsolateral prefrontal cortex while viewing unhealthy compared with healthy foods. In adults there was no correlation between BMI and neural response to unhealthy compared with healthy foods. Conclusions: Unhealthy foods might elicit more attention both in children and in adults. Children had stronger activation while viewing unhealthy compared with healthy foods in areas involved in reward, motivation, and memory. Furthermore, children activated a motivation and reward area located in the motor cortex more strongly than did adults in response to unhealthy foods. Finally, children with a higher BMI had less activation in inhibitory areas in response to unhealthy foods, which may mean they are more susceptible to tempting food cues.

Can cruisers make a difference?
Franeker, Jan Andries van - \ 2016

Wageningen Marine

Inferring 222Rn soil fluxes from ambient 222Rn activity and eddy covariance measurements of CO2
Laan, Sander van der; Manohar, Swagath ; Vermeulen, Alex ; Bosveld, Fred ; Meijer, Harro ; Manning, Andrew ; Molen, Michiel van der; Laan-Luijkx, Ingrid van der - \ 2016
Atmospheric Measurement Techniques 9 (2016)11. - ISSN 1867-1381 - p. 5523 - 5533.
We present a new methodology, which we call Single Pair of Observations Technique with Eddy Covariance (SPOT-EC), to estimate regional-scale surface fluxes of 222Rn from tower-based observations of 222Rn activity concentration, CO2 mole fractions and direct CO2 flux measurements from eddy covariance. For specific events, the regional (222Rn) surface flux is calculated from short-term changes in ambient (222Rn) activity concentration scaled by the ratio of the mean CO2 surface flux for the specific event to the change in its observed mole fraction. The resulting 222Rn surface emissions are integrated in time (between the moment of observation and the last prior background levels) and space (i.e. over the footprint of the observations). The measurement uncertainty obtained is about ±15 % for diurnal events and about ±10 % for longer-term (e.g. seasonal or annual) means. The method does not provide continuous observations, but reliable daily averages can be obtained. We applied our method to in situ observations from two sites in the Netherlands: Cabauw station (CBW) and Lutjewad station (LUT). For LUT, which is an intensive agricultural site, we estimated a mean 222Rn surface flux of (0.29 ± 0.02) atoms cm−2 s−1 with values  > 0.5 atoms cm−2 s−1 to the south and south-east. For CBW we estimated a mean 222Rn surface flux of (0.63 ± 0.04) atoms cm−2 s−1. The highest values were observed to the south-west, where the soil type is mainly river clay. For both stations good agreement was found between our results and those from measurements with soil chambers and two recently published 222Rn soil flux maps for Europe. At both sites, large spatial and temporal variability of 222Rn surface fluxes were observed which would be impractical to measure with a soil chamber. SPOT-EC, therefore, offers an important new tool for estimating regional-scale 222Rn surface fluxes. Practical applications furthermore include calibration of process-based 222Rn soil flux models, validation of atmospheric transport models and performing regional-scale inversions, e.g. of greenhouse gases via the SPOT 222Rn-tracer method.
Global Carbon Budget 2016
Quéré, C. Le; Andrew, R.M. ; Canadell, J.G. ; Sitch, Stephen ; Korsbakken, Jan Ivar ; Peters, Glen P. ; Manning, Andrew C. ; Boden, Thomas A. ; Tans, Pieter P. ; Houghton, Richard A. ; Keeling, Ralph F. ; Alin, Simone ; Andrews, Oliver D. ; Anthoni, Peter ; Barbero, Leticia ; Bopp, Laurent ; Chevallier, Frédéric ; Chini, Louise P. ; Ciais, Philippe ; Currie, Kim ; Delire, Christine ; Doney, Scott C. ; Friedlingstein, Pierre ; Gkritzalis, Thanos ; Harris, Ian ; Hauck, Judith ; Haverd, Vanessa ; Hoppema, Mario ; Klein Goldewijk, Kees ; Jain, Atul K. ; Kato, Etsushi ; Körtzinger, Arne ; Landschützer, Peter ; Lefèvre, Nathalie ; Lenton, Andrew ; Lienert, Sebastian ; Lombardozzi, Danica ; Melton, Joe R. ; Metzl, Nicolas ; Millero, Frank ; Monteiro, Pedro M.S. ; Munro, David R. ; Nabel, Julia E.M.S. ; Nakaoka, Shin-Ichiro ; O'Brien, Kevin ; Olsen, Are ; Omar, Abdirahman M. ; Ono, Tsuneo ; Pierrot, Denis ; Poulter, Benjamin ; Rödenbeck, Christian ; Salisbury, Joe ; Schuster, Ute ; Séférian, Roland ; Skjelvan, Ingunn ; Stocker, Benjamin D. ; Sutton, Adrienne J. ; Takahashi, Taro ; Tian, Hanqin ; Tilbrook, Bronte ; Laan-Luijkx, I.T. van der; Werf, Guido R. Van Der; Viovy, Nicolas ; Walker, Anthony P. ; Wiltshire, Andrew J. ; Zaehle, Sönke - \ 2016
Global Carbon Budget 2016
Quéré, Corinne Le; Andrew, Robbie M. ; Canadell, Josep G. ; Sitch, Stephen ; Korsbakken, Jan Ivar ; Peters, Glen P. ; Manning, Andrew C. ; Boden, Thomas A. ; Tans, Pieter P. ; Houghton, Richard A. ; Keeling, Ralph F. ; Alin, Simone ; Andrews, Oliver D. ; Anthoni, Peter ; Barbero, Leticia ; Bopp, Laurent ; Chevallier, Frédéric ; Chini, Louise P. ; Ciais, Philippe ; Currie, Kim ; Delire, Christine ; Doney, Scott C. ; Friedlingstein, Pierre ; Gkritzalis, Thanos ; Harris, Ian ; Hauck, Judith ; Haverd, Vanessa ; Hoppema, Mario ; Klein Goldewijk, Kees ; Jain, Atul K. ; Kato, Etsushi ; Körtzinger, Arne ; Landschützer, Peter ; Lefèvre, Nathalie ; Lenton, Andrew ; Lienert, Sebastian ; Lombardozzi, Danica ; Melton, Joe R. ; Metzl, Nicolas ; Millero, Frank ; Monteiro, Pedro M.S. ; Munro, David R. ; Nabel, Julia E.M.S. ; Nakaoka, S. ; O'Brien, Kevin ; Olsen, Are ; Omar, Abdirahman M. ; Ono, Tsuneo ; Pierrot, Denis ; Poulter, Benjamin ; Rödenbeck, Christian ; Salisbury, Joe ; Schuster, Ute ; Schwinger, Jörg ; Séférian, Roland ; Skjelvan, Ingunn ; Stocker, Benjamin D. ; Sutton, Adrienne J. ; Takahashi, Taro ; Tian, Hanqin ; Tilbrook, Bronte ; Laan-Luijkx, Ingrid T. van der; Werf, Guido R. van der; Viovy, Nicolas ; Walker, Anthony P. ; Wiltshire, Andrew J. ; Zaehle, Sönke - \ 2016
Earth System Science Data 8 (2016)2. - ISSN 1866-3508 - p. 605 - 649.
Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere – the “global carbon budget” – is important to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe data sets and methodology to quantify all major components of the global carbon budget, including their uncertainties, based on the combination of a range of data, algorithms, statistics, and model estimates and their interpretation by a broad scientific community. We discuss changes compared to previous estimates and consistency within and among components, alongside methodology and data limitations. CO2 emissions from fossil fuels and industry (EFF) are based on energy statistics and cement production data, respectively, while emissions from land-use change (ELUC), mainly deforestation, are based on combined evidence from land-cover change data, fire activity associated with deforestation, and models. The global atmospheric CO2 concentration is measured directly and its rate of growth (GATM) is computed from the annual changes in concentration. The mean ocean CO2 sink (SOCEAN) is based on observations from the 1990s, while the annual anomalies and trends are estimated with ocean models. The variability in SOCEAN is evaluated with data products based on surveys of ocean CO2 measurements. The global residual terrestrial CO2 sink (SLAND) is estimated by the difference of the other terms of the global carbon budget and compared to results of independent dynamic global vegetation models. We compare the mean land and ocean fluxes and their variability to estimates from three atmospheric inverse methods for three broad latitude bands. All uncertainties are reported as ±1σ, reflecting the current capacity to characterise the annual estimates of each component of the global carbon budget. For the last decade available (2006–2015), EFF was 9.3 ± 0.5 GtC yr−1, ELUC 1.0 ± 0.5 GtC yr−1, GATM 4.5 ± 0.1 GtC yr−1, SOCEAN 2.6 ± 0.5 GtC yr−1, and SLAND 3.1 ± 0.9 GtC yr−1. For year 2015 alone, the growth in EFF was approximately zero and emissions remained at 9.9 ± 0.5 GtC yr−1, showing a slowdown in growth of these emissions compared to the average growth of 1.8 % yr−1 that took place during 2006–2015. Also, for 2015, ELUC was 1.3 ± 0.5 GtC yr−1, GATM was 6.3 ± 0.2 GtC yr−1, SOCEAN was 3.0 ± 0.5 GtC yr−1, and SLAND was 1.9 ± 0.9 GtC yr−1. GATM was higher in 2015 compared to the past decade (2006–2015), reflecting a smaller SLAND for that year. The global atmospheric CO2 concentration reached 399.4 ± 0.1 ppm averaged over 2015. For 2016, preliminary data indicate the continuation of low growth in EFF with +0.2 % (range of −1.0 to +1.8 %) based on national emissions projections for China and USA, and projections of gross domestic product corrected for recent changes in the carbon intensity of the economy for the rest of the world. In spite of the low growth of EFF in 2016, the growth rate in atmospheric CO2 concentration is expected to be relatively high because of the persistence of the smaller residual terrestrial sink (SLAND) in response to El Niño conditions of 2015–2016. From this projection of EFF and assumed constant ELUC for 2016, cumulative emissions of CO2 will reach 565 ± 55 GtC (2075 ± 205 GtCO2) for 1870–2016, about 75 % from EFF and 25 % from ELUC. This living data update documents changes in the methods and data sets used in this new carbon budget compared with previous publications of this data set (Le Quéré et al., 2015b, a, 2014, 2013). All observations presented here can be downloaded from the Carbon Dioxide Information Analysis Center.
Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data
Woutersen, Ruud A. ; Soffers, Ans E.M.F. ; Kroese, E.D. ; Krul, Cyrille A.M. ; Laan, Jan Willem van der; Benthem, Jan van; Luijten, Mirjam - \ 2016
Regulatory Toxicology and Pharmacology 81 (2016). - ISSN 0273-2300 - p. 242 - 249.
Carcinogenicity - Non-genotoxic carcinogens - Predictivity - Preneoplastic lesions - Rat - Risk assessment - Sub-chronic toxicity - Tumours

Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic lesions in the sub-chronic study also did not induce tumours in the carcinogenicity study (True Negatives). Cellular hypertrophy appeared to be an unreliable predictor of carcinogenicity. The negative predictivity, the measure of the compounds evaluated that did not show any putative preneoplastic lesion in de sub-chronic studies and were negative in the carcinogenicity studies, was 75%, whereas the sensitivity, a measure of the sub-chronic study to predict a positive carcinogenicity outcome was only 5%. The specificity, the accuracy of the sub-chronic study to correctly identify non-carcinogens was 90%. When the chemicals which induced tumours generally considered not relevant for humans (33 out of 37 False Negatives) are classified as True Negatives, the negative predictivity amounts to 97%. Overall, the results of this retrospective study support the concept that chemicals showing no histopathological risk factors for neoplasia in a sub-chronic study in rats may be considered non-carcinogenic and do not require further testing in a carcinogenicity study.

Data-architectuur natuur
Bulens, J.D. ; Boss, M. - \ 2016
Wageningen : Alterra, Wageningen-UR (Alterra-rapport 2737) - 35 p.
milieumonitoring - ecologie - monitoring - informatiemanagement - milieuwetgeving - natuur - environmental monitoring - ecology - information management - environmental legislation - nature
Het Rijk en de provincies werken samen aan één samenhangend systeem voor de ecologische
monitoring en natuurinformatie. Er wordt gezamenlijk gewerkt aan een samenhangend systeem van
onder andere landelijke en gebiedsgerichte ecologische monitoring om efficiënt gegevens in te winnen
en doelmatig met middelen om te gaan. Vaak is nu nog onbekend welke data nu precies beschikbaar
zijn, waar en in welke vorm. Juist omdat geput wordt uit diverse databronnen, is het belangrijk deze
inzichtelijk en vergelijkbaar voor betrokkenen beschikbaar te stellen. Het samenbrengen en
harmoniseren van data heeft een grote toegevoegde waarde om transparant en eenduidig deze data
te kunnen gebruiken. De beschreven data-architectuur als basis voor een informatievoorziening is
daarvoor een onmisbaar uitgangsprincipe.
In dit rapport is beschreven wat de basis is om tot een informatievoorziening te komen. Dit omvat het
ontwikkelen van domeinstandaarden (informatiemodellen), de inrichting van een infrastructuur en het
vormgeven van samenhangende processen of systemen om onder andere tot natuurrapportages te
komen. Dit laatste is in 2015 is in een aantal inventarisaties vastgelegd met aangegeven wat de
huidige situatie (IST) en de toekomstige, gewenste situatie (SOLL) van het natuurnetwerk in
Nederland is. Samen met deze inventarisaties maakt dit het beeld compleet. Dit vormt een kader om
komende, nieuwe ontwikkelingen aan te toetsen.
Voor de data-architectuur voor de informatievoorziening Natuur wordt in dit rapport als basis een
grondplaat geschetst en gevisualiseerd, waarin de basisobjecten voor de informatievoorziening zijn
benoemd. De Nederlandse referentie-architecturen, NORA en PETRA, zijn goed bruikbaar met de
aanvulling dat, uitstijgend boven de eigen organisatie, goede afspraken gemaakt moeten worden met
partners in de natuurinformatieketen. In het rapport Monitoring en Informatievoorziening
Natuurrapportages [Batenburg 2015] is dit aspect benoemd en uitgewerkt. Voor het samenbrengen en
harmoniseren is het belangrijk het principe van het scheiden van data en processen voor informatie
verwerkende systemen te hanteren. Voor een beschrijving in de vorm van objecten met
eigenschappen is het cruciaal dat er eenduidige definities worden gebruikt. Hiervoor moeten
bestaande definities afkomstig uit verschillenden bronnen goed op elkaar afgestemd zijn. Het verdient
aanbeveling definities in een gegevenscatalogus bij elkaar te brengen en centraal via een register te
Dit betekent ook dat de data los van de gebruikte systemen opgeslagen moeten worden. Deze komen
zo ook beschikbaar voor andere processen. Hergebruik vergroot dan in sterke mate de waarde van de
gegenereerde data. Scheiding van data enerzijds en processen en regels anderzijds zijn daarmee
cruciaal en kunnen veel meerwaarde creëren. Ruwe (maar wel gevalideerde) data zijn de basis voor
afgeleide data en informatie. Het is daarom van belang te investeren in kwalitatief goede basisdata.
Houd de data (informatie) bij de bron. Daar is de kennis voor het onderhoud en beheer van de
inhoudelijk component het best belegd. Maar realiseer wel slechts één toegang tot alle informatie voor
Natuur. Dit kan in de vorm van een landelijke voorziening, informatiehuis of soortgelijk. In dit licht zijn
relevante ontwikkelingen als het Digitale Stelsel Omgevingswet (voorheen de Laan van de
Leefomgeving) en INSPIRE lopende ontwikkelingen waarop aansluiting moet worden gezocht.
De amazone slaat minder CO2 op
Laan-Luijkx, Ingrid van der - \ 2016
Onderzoekers slaan alarm: Amazone verstikt door droogte
Laan-Luijkx, Ingrid van der - \ 2016
In de Trouw (krant)In de Trouw (krant)
Regional atmospheric CO2 inversion reveals seasonal and geographic differences in Amazon net biome exchange
Alden, C.B. ; Miller, J.B. ; Gatti, L.V. ; Gloor, M.M. ; Laan-Luijkx, I.T. van der; Krol, M.C. ; Guan, K. ; Michalak, A.M. ; Touma, T. ; Andrew, A. ; Basso, L.S. ; Correia, C.S.C. ; Domingues, L.G. ; Joiner, J. ; Lyapustin, A. ; Peters, W. ; Shiga, Y.P. ; Thoning, K. ; Velde, I.R. van der; Leeuwen van, T.T. ; Yadav, V. ; Diffenbaugh, N.S. - \ 2016
Global Change Biology 22 (2016)10. - ISSN 1354-1013
Understanding tropical rainforest carbon exchange and its response to heat and drought is critical for quantifying the effects of climate change on tropical ecosystems, including global climate–carbon feedbacks. Of particular importance
for the global carbon budget is net biome exchange of CO2 with the atmosphere (NBE), which represents nonfire carbon fluxes into and out of biomass and soils. Subannual and sub-Basin Amazon NBE estimates have relied heavily on
process-based biosphere models, despite lack of model agreement with plot-scale observations. We present a new analysis of airborne measurements that reveals monthly, regional-scale (~1–8 9 106 km2) NBE variations. We
develop a regional atmospheric CO2 inversion that provides the first analysis of geographic and temporal variability in Amazon biosphere–atmosphere carbon exchange and that is minimally influenced by biosphere model-based first
guesses of seasonal and annual mean fluxes. We find little evidence for a clear seasonal cycle in Amazon NBE but do find NBE sensitivity to aberrations from long-term mean climate. In particular, we observe increased NBE (more carbon
emitted to the atmosphere) associated with heat and drought in 2010, and correlations between wet season NBE and precipitation (negative correlation) and temperature (positive correlation). In the eastern Amazon, pulses of
increased NBE persisted through 2011, suggesting legacy effects of 2010 heat and drought. We also identify regional differences in postdrought NBE that appear related to long-term water availability. We examine satellite proxies and
find evidence for higher gross primary productivity (GPP) during a pulse of increased carbon uptake in 2011, and lower GPP during a period of increased NBE in the 2010 dry season drought, but links between GPP and NBE
changes are not conclusive. These results provide novel evidence of NBE sensitivity to short-term temperature and moisture extremes in the Amazon, where monthly and sub-Basin estimates have not been previously available.
Heritability of body surface temperature in hens estimated by infrared thermography at normal or hot temperatures and genetic correlations with egg and feather quality
Loyau, T. ; Zerjal, T. ; Rodenburg, T.B. ; Fablet, J. ; Tixier-Boichard, M. ; Pinard-van der Laan, M.H. ; Mignon-Grasteau, S. - \ 2016
Animal 10 (2016)10. - ISSN 1751-7311 - p. 1594 - 1601.
adaptation - egg quality - genotype–environment interaction - heat stress - laying hens

Exposure of laying hens to chronic heat stress results in loss of egg production. It should be possible to improve hen resilience to chronic heat stress by genetic selection but measuring their sensitivity through internal temperature is time consuming and is not very precise. In this study we used infrared thermography to measure the hen’s capacity to dissipate heat, in a commercial line of laying hens subjected to cycles of neutral (N, 19.6°C) or high (H, 28.4°C) ambient temperatures. Mean body temperatures (BT) were estimated from 9355 infrared images of wing, comb and shank taken from 1200 hens. Genetic parameters were estimated separately for N and H temperatures. Correlations between BT and plumage condition were also investigated. Wing temperature had low heritability (0.00 to 0.09), consistent with the fact that wing temperature mainly reflects the environmental temperature and is not a zone of heat dissipation. The heritability of comb temperature was higher, from 0.15 to 0.19 in N and H conditions, respectively. Finally, the shank temperature provided the highest heritability estimates, with values of 0.20 to 0.22 in H and N conditions, respectively. Taken together, these results show that heat dissipation is partly under genetic control. Interestingly, the genetic correlation between plumage condition and shank and comb temperatures indicated that birds with poor condition plumage also had the possibility to dissipate heat through featherless areas. Genetic correlations of temperature measurements with egg quality showed that temperatures were correlated with egg width and weight, yolk brightness and yellowness and Haugh units only under H conditions. In contrast, shell colour was correlated with leg temperature only at thermo-neutrality.

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