Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Variable demand as a mean to sustainable first generation biofuels and biobased materials
Quist-Wessel, Foluke ; Gursel, Iris Vural ; Elbersen, Wolter ; Langeveld, Hans - \ 2019
In: European Biomass Conference and Exhibition Proceedings. - Lisbon, Portugal : ETA-Florence Renewable Energies (European Biomass Conference and Exhibition Proceedings ) - p. 1528 - 1535.
Agricultural productivity - Biobased chemicals - Biofuel policy - Biofuels - Food security - ILUC

This paper evaluates possible impacts of a variable biofuel demand (VBD) policy, i.e. a policy that adjusts biofuel production to changes in biomass availability as determined by variations in crop yield. The aim is to stimulate investments and enhancing efficiency in crop production while limiting competition with food in years of reduced crop availability.

Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation
Wang, Zerui ; Yuan, Jue ; Shen, Pingping ; Abskharon, Romany ; Lang, Yue ; Dang, Johnny ; Adornato, Alise ; Xu, Ling ; Chen, Jiafeng ; Feng, Jiachun ; Moudjou, Mohammed ; Kitamoto, Tetsuyuki ; Langeveld, Jan ; Appleby, Brian ; Ma, Jiyan ; Kong, Qingzhong ; Petersen, Robert B. ; Zou, Wen Quan ; Cui, Li - \ 2019
Molecular Neurobiology 56 (2019)8. - ISSN 0893-7648 - p. 5470 - 5470.

The original version of this article unfortunately contained a mistake. The email address Dr. Wen-Quan Zou, one of the corresponding authors should be written as “” instead of “”.

In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation
Wang, Zerui ; Yuan, Jue ; Shen, Pingping ; Abskharon, Romany ; Lang, Yue ; Dang, Johnny ; Adornato, Alise ; Xu, Ling ; Chen, Jiafeng ; Feng, Jiachun ; Moudjou, Mohammed ; Kitamoto, Tetsuyuki ; Langeveld, Jan ; Appleby, Brian ; Ma, Jiyan ; Kong, Qingzhong ; Petersen, Robert B. ; Zou, Wen Quan ; Cui, Li - \ 2019
Molecular Neurobiology 56 (2019)8. - ISSN 0893-7648 - p. 5456 - 5469.
Humanized transgenic mice - Polymorphism - Prion - Prion disease - Real-time quaking-induced conversion (RT-QuIC) - Serial protein misfolding cyclic amplification (sPMCA) - Variably protease-sensitive prionopathy (VPSPr)

Both sporadic variably protease-sensitive prionopathy (VPSPr) and familial Creutzfeldt-Jakob disease linked to the prion protein (PrP) V180I mutation (fCJDV180I) have been found to share a unique pathological prion protein (PrPSc) that lacks the protease-resistant PrPSc glycosylated at residue 181 because two of four PrP glycoforms are apparently not converted into the PrPSc from their cellular PrP (PrPC). To investigate the seeding activity of these unique PrPSc molecules, we conducted in vitro prion conversion experiments using serial protein misfolding cyclic amplification (sPMCA) and real-time quaking-induced conversion (RT-QuIC) assays with different PrPC substrates. We observed that the seeding of PrPSc from VPSPr or fCJDV180I in the sPMCA reaction containing normal human or humanized transgenic (Tg) mouse brain homogenates generated PrPSc molecules that unexpectedly exhibited a dominant diglycosylated PrP isoform along with PrP monoglycosylated at residue 181. The efficiency of PrPSc amplification was significantly higher in non-CJDMM than in non-CJDVV human brain homogenate, whereas it was higher in normal TgVV than in TgMM mouse brain homogenate. PrPC from the mixture of normal TgMM and Tg mouse brain expressing PrPV180I mutation (Tg180) but not TgV180I alone was converted into PrPSc by seeding with the VPSPr or fCJDV180I. The RT-QuIC seeding activity of PrPSc from VPSPr and fCJDV180I was significantly lower than that of sCJD. Our results suggest that the formation of glycoform-selective prions may be associated with an unidentified factor in the affected brain and the glycoform-deficiency of PrPSc does not affect the glycoforms of in vitro newly amplified PrPSc.

Recent insights on uncertainties present in integrated catchment water quality modelling
Tscheikner-Gratl, Franz ; Bellos, Vasilis ; Schellart, Alma ; Moreno-Rodenas, Antonio ; Muthusamy, Manoranjan ; Langeveld, Jeroen ; Clemens, Francois ; Benedetti, Lorenzo ; Rico-Ramirez, Miguel Angel ; Carvalho, Rita Fernandes de; Breuer, Lutz ; Shucksmith, James ; Heuvelink, Gerard B.M. ; Tait, Simon - \ 2019
Water Research 150 (2019). - ISSN 0043-1354 - p. 368 - 379.
Complexity management - Integrated catchment modelling - Sub-models of integrated modelling - Uncertainty - Water quality

This paper aims to stimulate discussion based on the experiences derived from the QUICS project (Quantifying Uncertainty in Integrated Catchment Studies). First it briefly discusses the current state of knowledge on uncertainties in sub-models of integrated catchment models and the existing frameworks for analysing uncertainty. Furthermore, it compares the relative approaches of both building and calibrating fully integrated models or linking separate sub-models. It also discusses the implications of model linkage on overall uncertainty and how to define an acceptable level of model complexity. This discussion includes, whether we should shift our attention from uncertainties due to linkage, when using linked models, to uncertainties in model structure by necessary simplification or by using more parameters. This discussion attempts to address the question as to whether there is an increase in uncertainty by linking these models or if a compensation effect could take place and that overall uncertainty in key water quality parameters actually decreases. Finally, challenges in the application of uncertainty analysis in integrated catchment water quality modelling, as encountered in this project, are discussed and recommendations for future research areas are highlighted.

Evaluation of dietary taste patterns as assessed by FFQ against 24-h recalls and biomarkers of exposure
Langeveld, A.W.B. van; Teo, P.S. ; Mars, M. ; Feskens, E.J.M. ; Graaf, C. de; Vries, J.H.M. de - \ 2019
European Journal of Clinical Nutrition 73 (2019)1. - ISSN 0954-3007 - p. 132 - 140.
Background/objective: Taste is of key importance in food choice and dietary patterns, but studies on taste profiles are limited. We previously assessed dietary taste patterns by 24 h recalls (24hR), but for epidemiological studies food frequency questionnaires (FFQ) may also be suitable. This study compared dietary taste patterns based on FFQ against 24hR and biomarkers of exposure. Subjects/methods: A taste database including 467 foods’ sweet, sour, bitter, salt, umami and fat sensation values was combined with food intake data to assess dietary taste patterns: the contribution to energy intake of 6 taste clusters. The FFQ’s reliability was assessed against 3-d 24hR and urinary biomarkers for sodium (Na) and protein intake (N) in Dutch men (n = 449) and women (n = 397) from the NQplus validation study (mean age 53 ± 11 y, BMI 26 ± 4 kg/m2). Results: Correlations of dietary taste patterns ranged from 0.39–0.68 between FFQ and 24hR (p < 0.05). Urinary Na levels, but not N levels, were positively associated with % energy intake from ‘salt, umami & fat’ tasting foods (Na; FFQ, r = 0.24, 24hR, r = 0.23, p < 0.001, N; FFQ, r = 0.08, p = 0.1394, 24hR, r = 0.05, p = 0.3427). Conclusions: The FFQ’s reliability against 24hR was acceptable to good for ranking of adults’ dietary taste patterns. Associations between dietary taste patterns and urinary Na and N were similar for FFQ and 24hR. These findings suggests that both FFQ and 24hR can be used in combination with our taste database, to investigate potential relationships between dietary taste patterns and subgroups at risk of obesity and chronic diseases such as cardiovascular disease.
Mobile Technology to Enable Tailor-Made Fertilizer Advice for Maize Smallholders in Western Kenya
Jindo, Keiji ; Schut, A.G.T. ; Langeveld, Hans ; Linders, René ; Hermelink, Marleen ; Munikah, Lydia ; Ittersum, M.K. van - \ 2018
In: ESA2018 XVe European Society for Agronomy Congress. - - p. 86 - 86.
Important lessons from new tailor-made services for smallholder farmers
Schut, A.G.T. ; Jindo, Keiji ; Langeveld, J.W.A. ; Rijerse, M. ; Munika, L. ; Matyoko, P. - \ 2018
In: Symposium Proceedings 13th European International Farming Systems Association (IFSA) Symposium. - IFSA - 13 p.
Mobile phone technology enables farmers to share information and receive tailor-made advice on farming practices. The objective of this work is to evaluate farmer perspectives on tailor-made services for improved on-farm nutrient application on smallholder farms in Western Kenya and Northern Tanzania. The service included agronomic advice and delivery of blended NPK fertilizer and hybrid maize seeds on credit. Advice on NPK fertilizer was based on best available geo-information in combination with a field quality assessment of the farmer. Pre- and post-season interviews were held with farmers in 46 villages in Northern Tanzania and Western Kenya. Soil samples were analysed and grain yields were measured in demarked plots. Impacts of the service on food self-sufficiency were evaluated by comparisons with a group of control farmers without tailored and farmers who received the service. Application of blended fertilizers increased grain weights when compared to plots without fertilizer. There were, however, no significant differences between farmers receiving tailored services and the to control group who often used fertilizers from other sources. We conclude that the technology might help to improve farm productivity, but only when combined with a complete agronomic package including pest control, local demonstrations and support of local agents or extension officers in environments where farmers have been exposed to hybrid seed and fertilizer.
'De opleiding organic agriculture is springlevend' : Aan Wageningen Universiteit neemt biologische landbouw een volwaardige plek in
Langeveld, C.A. - \ 2018
Ekoland (2018)4. - ISSN 0926-9142 - p. 20 - 21.
Gezond eten is minder smaakvol
Langeveld, Astrid van - \ 2018
Valorizing nutrients from palm oil mill effluent (Pome) digestate
Voogt, Juliën ; Elbersen, Wolter ; Meesters, Koen ; Blankenborg, Stefan ; Langeveld, Hans ; Quist-Wessel, Foluke - \ 2018
In: 26th European Biomass Conference and Exhibition Proceedings. - Florence : ETA-Florence Renewable Energies (European Biomass Conference and Exhibition Proceedings ) - ISBN 9788889407189 - p. 72 - 76.
Circular economy - Digestate - Economics - Palm oil - Recycling - Technology

Palm Oil Mill Effluent (POME) is considered a problematic waste, causing pollution problems: greenhouse gas emissions, water pollution with organic material, and nutrient pollution. POME is well suited for treatment in digestion tanks, generating methane for energy production. A technology screening showed membrane technology as the most promising technology for further processing of POME digestate into a mineral concentrate and high quality water. However, a techno-economic evaluation showed that the estimated costs related to further processing of POME digestate are currently higher than the potential savings. Options for cost reduction of the membrane technology and of the handling of the mineral concentrate should be explored. In an optimistic scenario the potential savings exceed the costs. If the concept is further developed, processing of POME digestate can contribute to the economic viability of digestion systems and to reducing the environmental impact of palm oil mills.

Matters of taste : Dietary taste patterns in the Netherlands
Langeveld, Astrid W.B. van - \ 2018
Wageningen University. Promotor(en): K. de Graaf, co-promotor(en): M. Mars; J.H.M. de Vries. - Wageningen : Wageningen University - ISBN 9789463432979 - 230
Dietary taste patterns by sex and weight status in the Netherlands
Langeveld, A.W.B. van; Teo, P.S. ; Vries, J.H.M. de; Feskens, E.J.M. ; Graaf, C. de; Mars, M. - \ 2018
The British journal of nutrition 119 (2018)10. - ISSN 0007-1145 - p. 1195 - 1206.
Taste is a key driver of food choice and intake. Taste preferences are widely studied, unlike the diet’s taste profile. This study assessed dietary taste patterns in the Netherlands by sex, BMI, age and education. A taste database, containing 476 foods’ taste values, was combined with 2-d 24-h recalls in two study populations. The percentage of energy intake from six taste clusters was assessed in the Dutch National Food Consumption Survey (DNFCS 2007–2010; n 1351) and in an independent observational study: the Nutrition Questionnaires plus (NQplus) study (2011–2013; n 944). Dietary taste patterns were similar across study populations. Men consumed relatively more energy from ‘salt, umami and fat’ (DNFCS; 24 % energy, NQplus study; 23 %)- and ‘bitter’ (7 %)-tasting foods compared with women (21 %, P<0·001, 22 %, P=0·005; 3 %, P<0·001, 4 %, P<0·001, respectively). Women consumed more % energy from ‘sweet and fat’ (15 %)- and ‘sweet and sour’ (13 %, 12 %, respectively)-tasting foods compared with men (12 %, P<0·001, 13 %, P=0·001; 10 %, P<0·001). Obese individuals consumed more % energy from ‘salt, umami and fat’- and less from ‘sweet and fat’-tasting foods than normal-weight individuals (‘salt, umami and fat’, men; obese both studies 26 %, normal-weight DNFCS 23 %, P=0·037, NQplus 22 %, P=0·001, women; obese 23 %, 24 %, normal weight 20 %, P=0·004, P=0·011, respectively, ‘sweet and fat’, men; obese 11 %, 10 %, normal weight 13 %, P<0·05, 14 %, P<0·01, women; obese 14 %, 15 %, normal weight 16 %, P=0·12, P=0·99). In conclusion, our taste database can be used to deepen our understanding of the role of taste in dietary intake in the Netherlands by sex, BMI, age and education.
Similar taste-nutrient relationships in commonly consumed Dutch and Malaysian foods
Teo, Pey Sze ; Langeveld, Astrid W.B. van; Pol, Korrie ; Siebelink, Els ; Graaf, Cees de; Yan, See Wan ; Mars, Monica - \ 2018
Appetite 125 (2018). - ISSN 0195-6663 - p. 32 - 41.
Commonly consumed - Cross-cultural - Foods - Nutrient content - Taste intensity
Three recent studies showed that taste intensity signals nutrient content. However, current data reflects only the food patterns in Western societies. No study has yet been performed in Asian culture. The Malaysian cuisine represents a mixture of Malay, Chinese and Indian foods. This study aimed to investigate the associations between taste intensity and nutrient content in commonly consumed Dutch (NL) and Malaysian (MY) foods. Perceived intensities of sweetness, sourness, bitterness, umami, saltiness and fat sensation were assessed for 469 Dutch and 423 Malaysian commonly consumed foods representing about 83% and 88% of an individual's average daily energy intake in each respective country. We used a trained Dutch (n = 15) and Malaysian panel (n = 20) with quantitative sensory Spectrum™ 100-point rating scales and reference solutions, R1 (13-point), R2 (33-point) and R3 (67-point). Dutch and Malaysian foods had relatively low mean sourness and bitterness (
Training of a Dutch and Malaysian sensory panel to assess intensities of basic tastes and fat sensation of commonly consumed foods
Teo, Pey Sze ; Langeveld, Astrid W.B. van; Pol, Korrie ; Siebelink, Els ; Graaf, Cees de; Martin, Christophe ; Issanchou, Sylvie ; Yan, See Wan ; Mars, Monica - \ 2018
Food Quality and Preference 65 (2018). - ISSN 0950-3293 - p. 49 - 59.
Cross-cultural - Panel performance - Spectrum - Taste profiling - Trained panel
Taste has a nutrient sensing function and guides food choices. Therefore, investigating taste profiles of dietary patterns - within and across cultures - is highly relevant for nutritional research. However, this demands for accurately described food-taste databases, which are supported with data on the reliability and performance of the sensory panel that determined the taste values.This study aimed to assess the performance of a trained Dutch and Malaysian sensory panel. More importantly, we assessed whether the standardized training procedure in the two countries yielded similar taste profiles with respect to 15 basic taste solutions, and 19 foods differing in tastes.A Dutch (n = 15) and Malaysian panel (n = 20) were trained for 56-63 h, using basic taste solutions and reference foods on 6 scales, i.e. sweetness, sourness, bitterness, umami, saltiness and fat sensation. Performance of both panels was described by discrimination, repeatability (RMSE), and agreement. Nineteen products with different sensory characteristics were profiled in the Netherlands and Malaysia; subsequently the obtained taste profiles were compared.Both panels were able to discriminate between solutions and products (all p < .001). A vast majority of the taste values could be reproduced; the RMSEs of the different taste values varied between 2.3 and 13.3%. Panel agreement was achieved after the training with solutions; however not for all attributes of the reference foods. Some taste values of the 19 foods were significantly different, however most of these differences were small (<10. points).Our descriptive training procedure yielded two panels from different cultures that were similar in panel performance. More importantly, they obtained similar taste profiles for 19 different foods. This implies that food-taste databases obtained with valid and standardized training procedures may be used to quantify the sensory profiles of dietary patterns of populations.
Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats
Mazza, M. ; Guglielmetti, Chiara ; Ingravalle, Francesco ; Brusadore, Sonia ; Langeveld, J.P.M. ; Ekateriniadou, Loukia V. ; Andreoletti, O. ; Casalone, C. ; Acutis, P.L. - \ 2017
Journal of General Virology 98 (2017)7. - ISSN 0022-1317 - p. 1963 - 1967.
The presence of lysine (K) at codon 222 has been associated with resistance to classical scrapie in goats, but few scrapie cases have been identified in 222Q/K animals. To investigate the contribution of the 222K variant to PrPres formation in natural and experimental Q/K scrapie cases, we applied an immunoblotting method based on the use of two different monoclonal antibodies, F99/97.6.1 and SAF84, chosen for their different affinities to 222K and 222Q PrP variants. Our finding that PrPres seems to be formed nearly totally by the 222Q variant provides evidence that the 222K PrP variant confers resistance to conversion to PrPres formation and reinforces the view that this mutation has a protective role against classical scrapie in goats.
Research Overview, Gaps, and Recommendations
Panoutsou, Calliope ; Langeveld, Hans ; Fritsche, Uwe R. ; Elbersen, Berien ; Dzene, Ilze ; Janssen, Rainer ; Kerckow, Birger ; Stojiljkovic, Dragoslava D. ; Gvero, Petar M. - \ 2017
In: Modeling and Optimization of Biomass Supply Chains Elsevier - ISBN 9780128123034 - p. 253 - 269.
Assessments - Biomass supply - Future research - Modeling tools

Modeling biomass supply and logistics has been included both directly and indirectly in European research and several initiatives have taken place through the last 15 years. Research has evolved from narrow assessments covering single or a few feedstock types and specific regions to harmonized approaches with consistent algorithms applied across Europe at different regional and temporal scales.The aim of this chapter is to provide an overview of research work in the area, identify gaps in research knowledge, and provide recommendations for future to research in the field of modeling biomass supply and logistics.

Genetic resistance to transmissible spongiform encephalopathies (TSE) in goats
Ricci, A. ; Allende, A. ; Bolton, A. ; Chemaly, Marianne ; Davies, R. ; Fernandez Escamez, Pablo Salvador ; Girones, R. ; Herman, L. ; Koutsoumanis, K. ; Lindqvist, R. ; Norrung, Birgit ; Robertson, L.W. ; Ru, G. ; Sanaa, M. ; Skandamis, P.N. ; Speybroeck, Niko ; Simmons, Marion ; Kuile, Benno Ter; Threlfall, John ; Wahlstrom, H. ; Acutis, P.L. ; Andreoletti, O. ; Goldmann, Wilfred ; Langeveld, J. ; Windig, J.J. ; Palaez, A.O. ; Snary, E. - \ 2017
EFSA Journal 15 (2017)8. - ISSN 1831-4732 - 8 p.
Biomass Supply Assessments in Europe: Research Context and Methodologies
Panoutsou, C. ; Bauen, A. ; Elbersen, B.S. ; Dees, M. ; Stojadinovic, D. ; Glavonjic, B. ; Zheliezna, T. ; Wenzelides, L. ; Langeveld, Hans - \ 2017
In: Modelling and Optimisation of Biomass Supply Chains / Panoutsou, C., Academic Press - ISBN 9780128123034 - p. 1 - 24.
Since early 2000, several biomass assessment studies were delivered at European and global level mostly driven by the increasing demand for the development of bioenergy and biofuels, and the need to secure sustainable, continuous supply for the emerging plants. Ongoing research and development and industrial development plus increased drivers to use renewable raw materials in industrial sectors beyond energy have seen the focus of the biomass markets widen to include value chains for bio-based chemicals, pharmaceuticals, and other materials. Consequently, research is now exploring increasingly varied configurations of value chains with the aims of understanding which types and quantifying how much biomass can be extracted sustainably, generate financial returns, and help the industry achieving high-quality products for consumers.
This chapter sets the scene for research on biomass supply assessments in Europe and reviews 40 studies delivered during the last 14 years. It analyzes context, key components in terms of terminology, framework conditions and assumptions, models used, and evidence provided so far for policy, research, and industry. It further discusses the main challenges, identifies gaps, and provides recommendations.
Protecting effect of PrP codons M142 and K222 in goats orally challenged with bovine spongiform encephalopathy prions
Fast, C. ; Goldmann, W. ; Berthon, P. ; Tauscher, Kerstin ; Andréoletti, O. ; Lantier, I. ; Rossignol, C. ; Bossers, A. ; Jacobs, J.G. ; Hunter, N. ; Groschup, Martin H. ; Lantier, F. ; Langeveld, J.P.M. - \ 2017
Veterinary Research 48 (2017)1. - ISSN 0928-4249
Breeding towards genetic resistance to prion disease is effective in eliminating scrapie. In sheep, classical forms of scrapie have been eradicated almost completely in several countries by breeding programs using a prion protein (PrP) gene (PRNP) amino acid polymorphism. For goats, field and experimental studies have provided evidence for several amino acid polymorphisms that are associated with resistance to scrapie, but only limited data are available concerning the susceptibility of caprine PRNP genotypes to BSE. In this study, goat kids representing five PRNP genotypes based on three polymorphisms (M142, Q211 and K222 and the wild type I142, R211 and Q222) were orally challenged with bovine or goat BSE. Wild type goats were killed with clinical signs between 24-28 months post inoculation (mpi) to both challenges, and goats with genotype R/Q211 succumbed between 29-36 mpi. I/M142 goats developed clinical signs at 44-45 mpi and M/M142 goats remained healthy until euthanasia at 48 mpi. None of the Q/K222 goats showed definite clinical signs. Taken together the highest attack ratios were seen in wild type and R/Q211 goats, and the lowest in I/M142, M/M142 and Q/K222. In all genotype groups, one or more goats remained healthy within the incubation period in both challenges and without detectable PrP deposition in the tissues. Our data show that both the K222 and M142 polymorphisms lengthen the incubation period significantly compared to wild type animals, but only K222 was associated with a significant increase in resistance to BSE infection after oral exposure to both BSE sources.
Variation in the prion protein in Dutch goats for selective breeding to eradicate Scrapie
Windig, Jack ; Priem, J. ; Bossers, A. ; Langeveld, J.P.M. ; Hoving, A.H. - \ 2017
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