Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    High Dietary Intake of Vegetable Protein Is Associated With Lower Prevalence of Renal Function Impairment: Results of the Dutch DIALECT-1 Cohort
    Oosterwijk, Milou M. ; Soedamah-Muthu, Sabita S. ; Geleijnse, Johanna M. ; Bakker, Stephan J.L. ; Navis, Gerjan ; Binnenmars, S.H. ; Gant, Christina M. ; Laverman, Gozewijn D. - \ 2019
    Kidney International Reports 4 (2019)5. - ISSN 2468-0249 - p. 710 - 719.
    diabetes mellitus type 2 - diet - kidney function - lifestyle

    Introduction: Dietary protein intake may influence development of renal function impairment in diabetes mellitus type 2 (T2DM). We assessed the association between sources of protein and prevalence of renal function impairment. Methods: Cross-sectional analyses were performed in baseline data of 420 patients of the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1)study. Protein intake was assessed using a Food Frequency Questionnaire, modified for accurate assessment of protein intake, including types and sources of protein. Renal function impairment was defined as estimated glomerular filtration rate (eGFR)<60 ml/min per 1.73 m 2 (Chronic Kidney Disease Epidemiology Collaboration formula). Results: Among 420 patients with T2DM, 99 renal function impairment cases were identified. Multivariate Cox proportional hazard models were used and adjusted for the main lifestyle and dietary factors. The prevalence ratios in the fully adjusted model were 1 (reference), 0.74 (95% confidence interval [CI]: 0.44–1.27; P = 0.28)and 0.47 (95% CI: 0.23–0.98; P = 0.04)according to increasing tertiles of vegetable protein intake. For animal protein intake the prevalence ratios were 1 (reference), 1.10 (95% CI: 0.64–1.88; P = 0.74)and 1.06 (95% CI: 0.56–1.99; P = 0.87)according to increasing tertiles of intake. Theoretical replacement models showed that replacing 3 energy percent from animal protein by vegetable protein lowered the prevalence ratio for the association with renal function impairment to 0.20 (95% CI: 0.06–0.63; P = 0.01). Conclusion: In conclusion, we found that higher intake of vegetable protein was associated with a lower prevalence of renal function impairment, and theoretical replacement of animal protein with vegetable protein was inversely associated with renal function impairment among patients with T2DM.

    Vitamin K Intake and Plasma Desphospho-Uncarboxylated Matrix Gla-Protein Levels in Kidney Transplant Recipients
    Boxma, P.Y. ; Berg, E. van den; Geleijnse, J.M. ; Laverman, G.D. ; Schurgers, L.J. ; Vermeer, C. ; Kema, I.P. ; Muskiet, F.A.J. ; Navis, G. ; Bakker, S.J.L. ; Borst, M.H. de - \ 2012
    PLoS ONE 7 (2012)10. - ISSN 1932-6203 - 8 p.
    coronary-artery calcium - vascular calcification - hemodialysis-patients - deficiency - menaquinones - disease - risk
    Vitamin K is essential for activation of ¿-carboxyglutamate (Gla)-proteins including the vascular calcification inhibitor matrix Gla-protein (MGP). Insufficient vitamin K intake leads to production of uncarboxylated, mostly inactive proteins and contributes to an increased cardiovascular risk. In kidney transplant recipients, cardiovascular risk is high but vitamin K intake and status have not been defined. We investigated dietary vitamin K intake, vascular vitamin K status and its determinants in kidney transplant recipients. We estimated vitamin K intake in a cohort of kidney transplant recipients (n = 60) with stable renal function (creatinine clearance 61 [42–77] (median [interquartile range]) ml/min), who were 75 [35–188] months after transplantation, using three-day food records and food frequency questionnaires. Vascular vitamin K status was assessed by measuring plasma desphospho-uncarboxylated MGP (dp-ucMGP). Total vitamin K intake was below the recommended level in 50% of patients. Lower vitamin K intake was associated with less consumption of green vegetables (33 vs 40 g/d, p = 0.06) and increased dp-ucMGP levels (621 vs 852 pmol/L, p500 pmol/L) in 80% of patients. Multivariate regression identified creatinine clearance, coumarin use, body mass index, high sensitivity-CRP and sodium excretion as independent determinants of dp-ucMGP levels. In a considerable part of the kidney transplant population, vitamin K intake is too low for maximal carboxylation of vascular MGP. The high dp-ucMGP levels may result in an increased risk for arterial calcification. Whether increasing vitamin K intake may have health benefits for kidney transplant recipients should be addressed by future studies.
    Agro-landerij: een moderne, regionale samenwerking
    Prins, A.M. ; Galema, P. ; Beldman, A.C.G. ; Laverman, W. - \ 2011
    Wageningen : Wageningen UR
    agrarische bedrijfsvoering - akkerbouw - veehouderij - gemengde landbouw - innovaties - ondernemerschap - drenthe - farm management - arable farming - livestock farming - mixed farming - innovations - entrepreneurship - drenthe
    Het project regionaal gemengd bedrijf Zuidoost Drenthe is gericht op het maken van een businessplan voor een vergaande samenwerking tussen akkerbouwers en veehouders in zuidoost Drenthe, gebaseerd op specialisatie in de bedrijfsvoering. Het uiteindelijk doel is het opzetten van het Nieuw Gemengd Bedrijf, waarin (lokale) ondernemers – die in verschillende takken van sport opereren – en bewoners van het gebied samenwerken. Kortom, samenwerkingsvormen op het gebied van voer, energie, mest en recreatie (beleving). Nieuwe vormen van landbouw vragen om innovatie, samenwerken en risicospreiding, om mee te kunnen gaan in de tijd en klaar te zijn voor de toekomst. De economische structuren vragen erom en de landbouw is in zuidoost Drenthe een belangrijke drager van de economie.
    De wending in regiotransitie : kansen voor een complementaire ondernemende aanpak!
    Kortstee, H.J.M. ; Hoop, D.W. de; Beldman, A.C.G. ; Prins, A.M. ; Laverman, W. ; Schans, J.W. van der; Hamers-van den Berkmortel, N.W.T.H. van den - \ 2009
    Den Haag : LEI Wageningen UR
    regionale planning - landbouw - landschap - innovaties - platteland - gebiedsgericht beleid - regional planning - agriculture - landscape - innovations - rural areas - integrated spatial planning policy
    In de brochure ‘De wending in regiotransitie’ van het LEI wordt een nieuwe aanvullende aanpak beschreven voor gebiedsprocessen in de regio. In deze benadering krijgen burgers en ondernemers niet alleen een 'stem' in de inrichting van een gebied, maar wordt ook aandacht gegeven aan het individuele ontwikkelingsperspectief van ondernemers. In deze aanpak krijgt 'strategie' een prominente plaats
    Spatiotemporal stability of an ammonia oxidizing community in a nitrogen-saturated forest soil
    Laverman, A.M. ; Speksnijder, A.G.C.L. ; Braster, M. ; Kowalchuk, G.A. ; Verhoef, H.A. ; Verseveld, H.W. - \ 2001
    Microbial Ecology 42 (2001)1. - ISSN 0095-3628 - p. 35 - 45.
    gradient gel-electrophoresis - 16s ribosomal-rna - vertical-distribution - class proteobacteria - beta-subdivision - gene-sequences - bacteria - nitrification - populations - diversity
    Elevated levels of nitrogen input into various terrestrial environments in recent decades have led to increases in soil nitrate production and leaching. However, nitrifying potential and nitrifying activity tend to be highly variable over space and time, making broad-scale estimates of nitrate production difficult. This study investigates whether the high spatiotemporal variation in nitrate production might be explained by differences in the structure of ammonia-oxidizing bacterial communities in nitrogen-saturated coniferous forest soils. The diversity of ammonia-oxidizing bacteria of the b-subgroup Proteobacteria was therefore investigated using two different PCR-based approaches. The first targeted the 16S rRNA gene and involved temporal temperature gradient electrophoresis (TTGE) of specifically amplified PCR products, with subsequent band excision and nucleotide sequence determination. The second approach involved the cloning and sequencing of PCR-amplified amoA gene fragments. All recovered 16S rDNA sequences were closely related to the culture strain Nitrosospira sp. AHB1, which was isolated from an acid soil and is affiliated with Nitrosospira cluster 2, a sequence group previously shown to be associated with acid environments. All amoA-like sequences also showed a close affinity with this acid-tolerant Nitrosospira strain, although greater sequence variation could be detected in the amoA analysis. The ammonia-oxidizing bacterial community in the nitrogen-saturated coniferous forest soil was determined to be very stable, showing little variation between different organic layers and throughout the year, despite large differences in the total Bacterial community structure as determined by 16S rDNA DGGE community fingerprinting. These results suggest that environmental heterogeneity affecting ammonia oxidizer numbers and activity, and not ammonia oxidizer community structure, is chiefly responsible for spatial and temporal variation in nitrate production in these acid forest soils.
    Identical transcriptional control of the divergently transcribed prtP and prtM genes that are required for proteinase production in Lactococcus lactis SK11.
    Marugg, J.D. ; Kranenburg, R. van; Laverman, P. ; Rutten, G.A.M. ; Vos, W.M. de - \ 1996
    Journal of Bacteriology 178 (1996). - ISSN 0021-9193 - p. 1525 - 1531.
    Medium dependent regulation of proteinase gene expression in Lactococcus lactis: control of transcription initiation by specific dipeptides.
    Marugg, J.D. ; Meijer, W. ; Kraneburg, R. van; Laverman, P. ; Bruinenberg, P.G. ; Vos, W.M. de - \ 1995
    Journal of Bacteriology 177 (1995). - ISSN 0021-9193 - p. 2982 - 2989.
    Kwaliteitszorg in de afzetketen van bloemisterijprodukten.
    Laverman, L.D. ; Zuurbier, P.J.P. - \ 1988
    Wageningen : Vakgroep Bedrijfskunde LU - 65 p.
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