Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus
    Minnaard, R. ; Schrauwen, P. ; Schaart, G. ; Jorgensen, J.A. ; Lenaers, E. ; Mensink, M.R. ; Hesselink, M.K.C. - \ 2009
    Journal of Clinical Endocrinology and Metabolism 94 (2009)10. - ISSN 0021-972X - p. 4077 - 4085.
    magnetic-resonance-spectroscopy - insulin-resistance - triglyceride content - fatty rats - sensitivity - droplets - rosiglitazone - pathogenesis - progression - inhibition
    Setting: A disordered lipid metabolism is implicated in the development of skeletal muscle insulin resistance. Lipid droplet proteins of the PAT [perilipin, adipocyte differentiation-related protein (ADRP), and TIP47] family have been shown to regulate lipid accumulation and intracellular metabolism in other tissues. Objective: This study aimed to explore the role of the PAT proteins OXPAT and ADRP in skeletal muscle lipid metabolism and their putative role in modulating insulin sensitivity. Design: Muscle OXPAT and ADRP protein content was examined during the development of insulin resistance in Zucker diabetic fatty (ZDF) rats and in type 2 diabetes patients and BMI-matched control subjects. Furthermore, we examined the effect of 8 wk of insulin sensitizing by rosiglitazone on muscle OXPAT and ADRP content. Results: OXPAT and ADRP protein expression is muscle fiber type specific in humans and rats, with highest protein content in fibers containing most intramyocellular lipids (IMCL). Muscle OXPAT and ADRP protein content was 2- to 3-fold higher in ZDF rats during the progression of type 2 diabetes than in lean normoglycemic control rats, which was paralleled by high IMCL levels. Muscle OXPAT and ADRP content, as well as IMCL level, was not different between type 2 diabetes patients and control subjects. ADRP content was negatively associated with insulin-stimulated glucose uptake (r = -0.50; P = 0.017). Interestingly, rosiglitazone treatment decreased muscle OXPAT (-29%) and ADRP (-28%) content in diabetes patients, without affecting IMCL. Conclusions: These results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes
    Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
    Phielix, E. ; Schrauwen-hinderling, V.B. ; Mensink, M. ; Lenaers, E. ; Meex, R. ; Hoeks, J. ; Kooi, M.E. ; Moonen-Kornips, E. ; Sels, J.P. ; Hesselink, M.K.C. ; Schrauwen, P. - \ 2008
    Diabetes 57 (2008)11. - ISSN 0012-1797 - p. 2943 - 2949.
    OBJECTIVE—A lower in vivo mitochondrial function has been reported in both type 2 diabetic patients and first-degree relatives of type 2 diabetic patients. The nature of this reduction is unknown. Here, we tested the hypothesis that a lower intrinsic mitochondrial respiratory capacity may underlie lower in vivo mitochondrial function observed in diabetic patients.
    Monitoring protein utilization by use of milk urea nitrogen.
    Hof, G. ; Lenaers, P.J. ; Tamminga, S. - \ 1997
    In: Mid-South Ruminant Nutrition Conference, Dallas-Fort Worth Airport, 1-2 May - p. 74 - 81.
    Milk Urea Nitrogen as a Tool to Monitor the Protein Nutrition of Dairy Cows
    Hof, G. ; Vervoorn, M.D. ; Lenaers, P.J. ; Tamminga, S. - \ 1997
    Journal of Dairy Science 80 (1997). - ISSN 0022-0302 - p. 3333 - 3340.
    The relationship between protein nutrition and milk urea N was investigated in three experiments with a total of 125 cows. After 4 wk of pretreatment, cows received 1 of 13 diets with different ratios of protein to energy for 16 wk. Milk was sampled individually for urea analyses during pretreatment and during wk 1, 5, 10, and 15 of treatment. Results were compared with N losses estimated from rumen fermentation and with N losses of metabolic origin.

    The mean milk urea N concentration was 12.6 mg/ 100 ml of milk (range, 9.0 to 18.3 mg). For bulk samples especially, the rumen efflux of crude protein intake was the main determinant of the variation in milk urea N (r2 = 0.81; residual SD = 1.1). However, N losses from the rumen explained only about 50% of the variation in the milk urea N content of samples from individual cows. The N losses of metabolic origin, which, in these experiments, were responsible for 47 to 100% of urinary N losses, were not related to milk urea N. Results showed that regular measurement of milk urea N in bulk samples can be used to monitor N losses from rumen fermentation. However, the value does not give an indication of the efficiency with which the absorbed protein is utilized.
    Het effect van het toevoegen van een suikeroplossing of formaldehyde op de bestendigheid en voederwaarde van sojaschroot.
    Goelema, J.O. ; Hof, G. ; Tamminga, S. ; Lenaers, P.J. - \ 1995
    In: Verslag 20e Studiedag voor Nederlandstalige Voedingsonderzoekers, Leuven - p. 60 - 61.
    Efficiency of protein utilization in dairy cows.
    Hof, G. ; Tamminga, S. ; Lenaers, P.J. - \ 1994
    Livestock Production Science (1994). - ISSN 0301-6226 - p. 169 - 178.
    Monensin for dairy cows. Results of the feeding experiment at the Ir. A.P. Minderhoudhoeve.
    Hof, G. ; Lenaers, P.J. ; Horst, W. van der; Steeghs, R. ; Wal, P. van der - \ 1994
    Unknown Publisher - 165 p.
    Mogelijkheden voor het gebruik van IVO-proeven voor evaluatie van de energienormen voor vleesstieren.
    Hof, G. ; Lenaers, P.J. - \ 1993
    Wageningen : Leerstoelgroep Diervoeding (Rapport Projectgroep Normen Vleesvee ) - 6 p.
    Bovine somatotropin and feed interactions in dairy cows.
    Hof, G. ; Lenaers, P.J. ; Tamminga, S. ; Jonker, L.J. ; Koffeman, A.I. - \ 1991
    Livestock Production Science 28 (1991). - ISSN 0301-6226 - p. 21 - 36.
    The importance of roughage in the rearing period on the feed intake and performance of adult dairy cows
    Hof, G. ; Lenaers, P.J. - \ 1984
    Livestock Production Science 11 (1984). - ISSN 0301-6226 - p. 287 - 302.
    Relaties tussen fysisch-chemische kenmerken van ruwvoeders en hun opname door herkauwers
    Hof, G. ; Boer, H. ; Lenaers, P.J. - \ 1984
    In: Proc. 9th Conf. Dutch res. workers in Animal Nutrition - p. 23 - 26.
    Celwanden, parameters voor de ruwvoederopname?
    Hof, G. ; Boer, H. ; Lenaers, P.J. - \ 1984
    Landbouwkundig Tijdschrift 96 (1984)6. - ISSN 0927-6955 - p. 25 - 28.
    Veldbonenkuil als voeder voor rundvee. 2. De vrijwillige opname door eenjarige ossen
    Lenaers, P.J. ; Hof, G. - \ 1982
    Bedrijfsontwikkeling 13 (1982). - ISSN 0303-4127 - p. 347 - 351.
    rundvee - tuinbonen - kuilvoer - vicia faba - cattle - faba beans - silage
    Doel, opzet en resultaten van een opnameproef
    Veldbonenkuil als voeder voor rundvee. 1. Inkuilverliezen, dier verteerbaarheid en voederwaarde
    Hof, G. ; Lenaers, P.J. ; Boer, H. ; Deinum, B. - \ 1982
    Bedrijfsontwikkeling 13 (1982). - ISSN 0303-4127 - p. 343 - 346.
    tuinbonen - kuilvoer - stieren - vicia faba - faba beans - silage - steers
    Om het inzicht in de waarde van veldbonensilage als rundveevoeder te verbreden, werden twee kuilen, varierend in oogststadium, onderzocht op inkuilverliezen, kuilkwaliteit en de dier-verteerbaarheid
    De verdringing van gras door krachtvoer
    Hof, G. ; Lenaers, P.J. ; Flikweert, S. - \ 1981
    Bedrijfsontwikkeling 12 (1981). - ISSN 0303-4127 - p. 27 - 29.
    rundvee - concentraten - begrazing - cattle - concentrates - grazing
    Het economisch rendement van bijvoeding in de weide is afhankelijk van een aantal factoren, die deels samenhangen met de individuele bedrijfsvoering. Een factor betreft de vermindering in dagelijkse grasopname door het krachtvoer. In het kader van een doctoraalonderzoek voor de vakgroep Veevoeding heeft Flikweert een literatuurstudie verricht om hierin meer inzicht te krijgen
    De invloed van het ruwvoeraandeel in het opfokrantsoen op de voeropname van melkvee
    Hof, G. ; Lenaers, P.J. ; Wal, Tj. van der; Boonzaaijer, S. - \ 1981
    Landbouwkundig Tijdschrift 93 (1981). - ISSN 0927-6955 - p. 185 - 192.
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