Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

    Records 1 - 6 / 6

    • help
    • print

      Print search results

    • export

      Export search results

    Check title to add to marked list
    Commentary 2 to the manifesto for the marine social sciences: applied social science
    Kraan, Marloes ; Linke, Sebastian - \ 2020
    Maritime Studies 19 (2020). - ISSN 1872-7859 - p. 129 - 130.
    Implementing the Landing Obligation. An Analysis of the Gap Between Fishers and Policy Makers in the Netherlands
    Kraan, Marloes ; Verweij, Marieke - \ 2020
    In: Collaborative Research in Fisheries / Holm, P., Hadjimichael, M., Linke, S., Mackinson, S., Springer (MARE Publication Series ) - ISBN 9783030267834 - p. 231 - 248.
    perceptions - landing obligation - discards - trust - collaborative research
    The introduction of the landing obligation is a radical change of the European fisheries policy that has widened the gap between fishers and policy officers in the Netherlands. Especially the mixed demersal trawl fisheries have to adjust to this new measure, which requires a concerted effort between ministry, fleet and research institutions. This chapter describes the implementation process of the landing obligation in the Netherlands (between 2013–2015) and how it has been met with strong opposition by Dutch fishers. This chapter argues that such opposition stems not only from interests, but also from strongly held perceptions about the (ecological) consequences of the measure, as was clear from observing meetings and interviewing key actors. Although several meetings had been organised by the ministry to discuss the landing obligation with fishers, perception differences were not discussed explicitly. Discussions rather seemed to be parallel monologues where parties failed to meet a shared understanding. This situation jeopardises real cooperation in the preparation for full implementation of the landing obligation. The chapter ends with a discussion on possible ways to bridge the gap between fishers and policy officers
    Hepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
    Sander, Leif E. ; Dutton Sackett, Sara ; Dierssen, Uta ; Beraza, Naiara ; Linke, Reinhold P. ; Muller, Michael ; Magarian Blander, Julie ; Tacke, Frank ; Trautwein, Christian - \ 2010
    Wageningen University
    Mus musculus - GSE22009 - PRJNA127473 - Mus musculus - GSE22009
    Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. Using a murine model for polymicrobial sepsis we show here that abrogation of APP production by hepatocyte-specific gp130 deletion, the signaling receptor shared by IL-6-family cytokines, dramatically increased mortality despite normal bacterial clearance. Hepatic gp130 signaling through signal transducer and activator of transcription (Stat)3 was required to control systemic inflammation. Notably, hepatic gp130/Stat3 activation was also a prerequisite to facilitate mobilization and tissue accumulation of myeloid-derived suppressor cells (MDSCs), a cell population mainly known for anti-inflammatory properties in cancer. We show that MDSCs were critical to regulate innate inflammation and their adoptive transfer efficiently protected gp130-deficient mice from sepsis-associated mortality. We identified serum amyloid A and Cxcl-1/KC as hepatic acute phase genes that cooperatively promoted MDSC mobilization, accumulation and survival. Administration of these proteins efficiently elevated MDSC numbers and reversed dysregulated inflammation and restored survival of gp130-deficient mice. Thus, gp130-dependent communication between the liver and MDSCs through acute phase proteins critically controls inflammatory responses during infection.
    Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    Sander, L.E. ; Sackett, S.D. ; Dierssen, U. ; Beraza, N. ; Linke, R. ; Müller, M.R. ; Blander, J.M. ; Tacke, F. ; Trautwein, C. - \ 2010
    Journal of Experimental Medicine 207 (2010)7. - ISSN 0022-1007 - p. 1453 - 1464.
    serum-amyloid-a - severe sepsis - signal transducer - liver-injury - gp130 - mice - inflammation - activation - mechanisms - pathway
    Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and antiinflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. Using a mouse model of polymicrobial sepsis, we show that abrogation of APP production by hepatocyte-specific gp130 deletion, the signaling receptor shared by IL-6 family cytokines, strongly increased mortality despite normal bacterial clearance. Hepatic gp130 signaling through STAT3 was required to control systemic inflammation. Notably, hepatic gp130-STAT3 activation was also essential for mobilization and tissue accumulation of myeloid-derived suppressor cells (MDSCs), a cell population mainly known for antiinflammatory properties in cancer. MDSCs were critical to regulate innate inflammation, and their adoptive transfer efficiently protected gp130-deficient mice from sepsis-associated mortality. The hepatic APPs serum amyloid A and Cxcl1/KC cooperatively promoted MDSC mobilization, accumulation, and survival, and reversed dysregulated inflammation and restored survival of gp130-deficient mice. Thus, gp130-dependent communication between the liver and MDSCs through APPs controls inflammatory responses during infection
    Amino-terminated organic monolayers on hydrogen-terminated silicon surfaces
    Sieval, A.B. ; Linke, R. ; Heij, G. ; Meijer, G. ; Zuilhof, H. ; Sudhölter, E.J.R. - \ 2001
    Langmuir 17 (2001). - ISSN 0743-7463 - p. 7554 - 7559.
    High-Quality Alkyl Monolayers on Silicon Surfaces
    Sieval, A.B. ; Linke, R. ; Zuilhof, H. ; Sudh"lter, E.J.R. - \ 2000
    Advanced Materials 12 (2000)19. - ISSN 0935-9648 - p. 1457 - 1460.
    Covalent attachment of functionalized monolayers onto silicon surfaces (see Figure for examples) is presented here as a strategy for surface modification. The preparation and structure of both unfunctionalized and functionalized alkyl-based monolayers are described, as are potential applications, for example, in the surface passivation of Si solar cells and for photopatterning of silicon surfaces.
    Check title to add to marked list

    Show 20 50 100 records per page

     
    Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.