|Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: The HALE project
Knoops, K.T.B. ; Groot, C.P.G.M. de; Kromhout, D. ; Perrin, A.E. ; Moreiras-Varela, O. ; Menotti, A. ; Staveren, W.A. van; Roth, Z. ; Brown, G. - \ 2005
Evidence-Based Ophthalmology 6 (2005)1. - ISSN 1555-9203 - p. 48 - 49.
Short and long term association of a single serum cholesterol measurement in middle-aged men in prediciton of fatal coronary and other cardiovascular events: a cross-cultural comparison through Europe
Menotti, A. ; Lanti, M. ; Kromhout, D. ; Kafatos, A. ; Nedeljkovic, S. ; Nissinen, A. - \ 2005
European Journal of Epidemiology 20 (2005)7. - ISSN 0393-2990 - p. 597 - 604.
heart-disease mortality - all-cause mortality - major risk-factors - blood-pressure - follow-up - 7 countries - cohorts - stroke - deaths - people
Aims: The purpose was to study the association of a single serum cholesterol measurement with early and late coronary and other cardiovascular deaths during 35 years of follow-up in samples of men aged 40¿59 years in five European countries. Methods and results: A single serum total cholesterol measurement was considered in samples from Finland (N = 1563), the Netherlands (N = 811), Italy (N = 1642), Serbia (N = 1537) and Greece (N = 1158) (total = 6711). Seven partitioned proportional hazards models were solved, one for each of seven independent 5-year blocks, to predict coronary, stroke, cardiovascular disease and all-cause mortality risk. Partitioned hazard scores were cumulated. The resulting curves showed a relatively constant strength in risk for coronary deaths as a function of baseline serum cholesterol levels, although a strong relationship during the first 10-year period was followed by a weaker relationship later on. The pooled estimates for the five countries gave a relative risk for 1 mmol/l of serum cholesterol (95% confidence intervals) of 1.44 (1.23¿1.68) for the first period; 1.52 (1.31¿1.76) for the second period; and 1.16 (1.02¿1.32) for the third period; 1.18 (1.05¿1.32) for the forth period; 1.17 (1.05¿1.31) for the fifth period; 1.22 (1.10¿1.35) for the sixth period; 1.18 (1.05¿1.32) for the seventh 5-year period of follow-up. No significant relationship were found between serum cholesterol and stroke and all-cause mortality, while intermediate findings were obtained for cardiovascular diseases. Conclusion: A single serum cholesterol measurement in middle aged-men maintains a strong relationship with the occurrence of coronary heart disease (CHD) deaths during 35 years of follow-up.
Long-term predictors of survival for the Seven Countries Study cohort from Crete : from 1960 to 2000
Moschandreas, J. ; Kafatos, A. ; Aravanis, C. ; Dontas, A. ; Menotti, A. ; Kromhout, D. - \ 2005
International Journal of Cardiology 100 (2005)1. - ISSN 0167-5273 - p. 85 - 91.
coronary-heart-disease - all-cause mortality - blood-pressure - risk-factors - 25-year mortality - stroke mortality - corfu cohort - follow-up - cholesterol - population
Background: In 1960, all male inhabitants of a series of villages in rural Crete, born between 1900 and 1919, were invited to participate in the Seven Countries Study. Analysis of 25-year mortality data from the 16 cohorts of participants indicated that the cohort from Crete had the lowest age-standardised all-cause and coronary heart disease death rates. Methods: At baseline, 686 Cretan men (98% of those invited) participated in health examinations. Mortality data were collected over 40 years. Time-fixed and updated covariate survival analysis techniques were applied to assess eight cardiovascular disease risk factors as long-term predictors of all-cause and cardiovascular disease mortality. Results: The median survival time was 32 years. All-cause and cardiovascular mortality rates were 26 and I I per 1000 person-years, respectively. Age (relative risk 1.11, 95% CI 1.09-1.13), diastolic blood pressure (relative risk 1.02, 95% CI 1.01-1.03), and smoking (relative risk 1.37, 95% CI 1.14-1.64) were positively associated and forced expiratory volume (relative risk 0.50, 95% Cl 0.36-0.68) was negatively associated with all-cause mortality. Age (relative risk 1.13, 95%CI 1.09-1.16), diastolic blood pressure (relative risk 1.01, 95%CI 1.001-1.03), and forced expiratory volume (relative risk 0.53, 95% CI 0.32-0.89) were independent predictors of cardiovascular mortality. Serum cholesterol concentration and body mass index were not independently associated with death risk. Conclusions: The Cretan cohort displays favourable 40-year survival. Even so, long-term predictors of the hazard of both all-cause and cardiovascular disease mortality are present. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Mediterranean Diet, Lifestyle Factors, and 10-year Mortality in Elderly European Men and Women. The HALE Project
Knoops, K.T.B. ; Groot, L.C.P.G.M. de; Kromhout, D. ; Perrin, A.E. ; Moreiras-Varela, O. ; Menotti, A. ; Staveren, W.A. van - \ 2004
JAMA: The Journal of the American Medical Association 292 (2004)12. - ISSN 0098-7484 - p. 1433 - 1439.
coronary-heart-disease - physical-activity - smoking-cessation - health behaviors - risk-factors - older men - cohort - survival - questionnaire - prevention
Context Dietary patterns and lifestyle factors are associated with mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer, but few studies have investigated these factors in combination. Objective To investigate the single and combined effect of Mediterranean diet, being physically active, moderate alcohol use, and nonsmoking on all-cause and cause-specific mortality in European elderly individuals. Design, Setting, and Participants The Healthy Ageing: a Longitudinal study in Europe (HALE) population, comprising individuals enrolled in the Survey in Europe on Nutrition and the Elderly: a Concerned Action (SENECA) and the Finland, Italy, the Netherlands, Elderly (FINE) studies, includes 1507 apparently healthy men and 832 women, aged 70 to 90 years in 11 European countries. This cohort study was conducted between 1988 and 2000. Main Outcome Measures Ten-year mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer. Results During follow-up, 935 participants died: 371 from cardiovascular diseases, 233 from cancer, and 145 from other causes; for 186, the cause of death was unknown. Adhering to a Mediterranean diet (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.68-0.88), moderate alcohol use (HR, 0.78; 95% Cl, 0.67-0.91), physical activity (HR, 0.63; 95% Cl, 0.55-0.72), and nonsmoking (HR, 0.65; 95% Cl, 0.57-0.75) were associated with a lower risk of all-cause mortality (HRs controlled for age, sex, years of education, body mass index, study, and other factors). Similar results were observed for mortality from coronary heart disease, cardiovascular diseases, and cancer. The combination of 4 low risk factors lowered the all-cause mortality rate to 0.35 (95% Cl, 0.28-0.44). In total, lack of adherence to this low-risk pattern was associated with a population attributable risk of 60% of all deaths, 64% of deaths from coronary heart disease, 61% from cardiovascular diseases, and 60% from cancer. Conclusion Among individuals aged 70 to 90 years, adherence to a Mediterranean diet and healthful lifestyle is associated with a more than 50% lower rate of all-causes and cause-specific mortality.
Cohort analysis of fruit and vegetable consumption and lung cancer mortality in European men
Jansen, M.C.J.F. ; Bueno-de Mesquita, H.B. ; Rasanen, L. ; Fidanza, F. ; Nissinen, A.M. ; Menotti, A. ; Kok, F.J. - \ 2001
International Journal of Cancer 92 (2001)9. - ISSN 0020-7136 - p. 913 - 918.
Our aim was to examine the relationship between fruit and vegetable consumption and lung cancer mortality in a cohort of European males. Around 1970, dietary intake of Finnish, Italian and Dutch middle-aged men was assessed using a cross-check dietary history. Complete baseline information was available for 3,108 men, of whom 1,578 were baseline smokers. We used Cox proportional hazard analyses to calculate risk estimates for the consumption in country-specific tertiles on lung cancer in smokers. During 25 years of follow-up, 149 lung cancer deaths occurred in the smokers. Fruit consumption was inversely associated with lung cancer mortality among smokers; compared with the lowest, adjusted RRs for the intermediate and highest tertiles were 0.56 (0.37-0.84) and 0.69 (0.46-1.02), p-trend 0.05. Only in the Dutch cohort was this association statistically significant [adjusted relative risks (RRs) 1.00, 0.33 (0.16-0.70) and 0.35 (0.16-0.74), p-trend 0.004]. In Finland lung cancer risk was lower with higher fruit intake but not significantly, whereas in Italy no association was observed. Stratifying on cigarette smoking intensity (non, light and heavy) revealed an inverse association in the heavy smokers only [adjusted RRs (95␌onfidence intervals [CI]) 1; 0.47 (0.26-0.84); 0.40 (0.20-0.78)). Vegetable consumption was not related to lung cancer risk in smokers. However, analyses stratified on cigarette smoking intensity gave some indication for a lower lung cancer risk with higher intake. In conclusion, in this prospective analysis among European smoking men, fruit intake was inversely related to lung cancer mortality. This association was confined to heavy cigarette smokers.
Role of smoking and diet in the cross-cultural variation in lung-cancer mortality : the Seven Countries Study
Mulder, I. ; Jansen, M.C.J.F. ; Smit, H.A. ; Jacobs, D.R. ; Menotti, A. ; Nissinen, A. ; Kromhout, D. - \ 2000
International Journal of Cancer 88 (2000). - ISSN 0020-7136 - p. 665 - 671.
We examined the role of smoking and diet in the cross-cultural variation in lung-cancer mortality, using aggregated data of the Seven Countries Study, a follow-up study comprising 12,763 middle-aged men in 16 cohorts in Europe, the United States and Japan, which started around 1960. Smoking habits were assessed with a standardised questionnaire. Dietary intake was collected in random sub-samples of each cohort by the dietary record method. Cohort-specific 25-year lung-cancer mortality among all men and among categories of smoking behaviour was related to smoking prevalence and population average dietary intake, respectively, using Poisson regression. Smoking prevalence was positively associated with lung-cancer mortality [risk ratio 1.47, 95␌onfidence interval (CI) 1.05-2.07, for an increase of 10 percentage points]. Lung-cancer mortality among smokers, which varied significantly among cultures, was positively associated with average fat intake, especially saturated fat intake (rate ratio 1.10, 95␌I 1.04-1.17, for an increase of 4.6 g) but not with unsaturated fat intake. Average fruit and vegetable intake were not related to lung-cancer mortality. Among never-smokers, the power to detect associations was low. In conclusion, both smoking prevalence and average fat intake, especially saturated fat, may play a role in the cross-cultural variation in lung-cancer mortality, either independently or by effect modification
|Fruit and vegetable consumption and lung cancer among smokers in Finland, Italy and The Netherlands
Jansen, M.C.J.F. ; Bueno-de Mesquita, H.B. ; Nissinen, A.M. ; Fidanza, F. ; Menotti, A. ; Kok, F.J. ; Kromhout, D. - \ 2000
In: Dietary anticarcinogens and antimutagens : Food and Cancer Prevention III, East Anglia 1999 / Johnson, I.T., Fenwick, G.R., Cambridge : RSC - p. 31 - 32.
|Dietary factors and pulmonary function : a cross-sectional study in middle-aged men from three European countries
Tabak, C. ; Smit, H.A. ; Rasanen, L. ; Fidanza, F. ; Menotti, A. ; Nissinen, A. ; Feskens, E.J.M. ; Heederik, D. - \ 1999
Thorax 54 (1999). - ISSN 0040-6376 - p. 1021 - 1026.
|Dietary fiber and plant foods in relation to colorectal cancer mortality: the seven countries study
Jansen, M.C.J.F. ; Bueno-de-Mesquita, H.B. ; Buzina, R. ; Fidanza, F. ; Menotti, A. ; Kok, F.J. ; Kromhout, D. - \ 1999
International Journal of Cancer 81 (1999). - ISSN 0020-7136 - p. 174 - 179.
|The cross-sectional association between fruit consumption and pulmonary function in middle-aged men.
Tabak, C. ; Smit, H.A. ; Feskens, E.J.M. ; Heederik, D. ; Rasanen, L. ; Nissinen, A. ; Fidanza, F. ; Menotti, A. ; Kromhout, D. - \ 1998
European Respiratory Journal 12 (1998). - ISSN 0903-1936 - p. 402S - 402S.
Fruit and fish consumption: a possible explanation for population differences in COPD mortality (The Seven Countries Study).
Tabak, C. ; Feskens, E.J.M. ; Heederik, D. ; Kromhout, D. ; Menotti, A. ; Blackburn, H.W. - \ 1998
European Journal of Clinical Nutrition 52 (1998). - ISSN 0954-3007 - p. 819 - 825.
|The effect of changes in smoking behaviour on the prediction of mortality.
Mulder, I. ; Smit, H.A. ; Menotti, A. - \ 1998
Irish Journal of Medical Science 167 (1998). - p. 16S - 16S.
|Potential markers for fruit and vegetable intake.
Jansen, M.C.J.F. ; Ocke, M.C. ; Menotti, A. - \ 1998
European Journal of Clinical Nutrition 52 (1998). - ISSN 0954-3007 - p. S47 - S47.
|Adherence to the European code against cancer in relation to long-term cancer mortality: intercohort comparisons from the Seven Countries Study.
Ocke, M.C. ; Bueno-de Mesquita, H.B. ; Feskens, E.J.M. ; Kromhout, D. ; Menotti, A. ; Blackburn, H. - \ 1998
Nutrition and Cancer 30 (1998). - ISSN 0163-5581 - p. 14 - 20.
|De Europese code tegen kanker in relatie tot kankersterfte: tussencohort vergelijkingen in de zeven landen studie.
Ock, M.C. ; Bueno de Mesquita, H.B. ; Feskens, E.J.M. ; Menotti, A. ; Blackburn, H. ; Kromhout, D. - \ 1997
Tijdschrift voor sociale geneeskunde 3 (1997). - ISSN 0040-7607 - p. 19 - 19.
Dietary pattern and 20 year mortality in elderly men in Finland, Italy and the Netherlands: Longitudinal cohort study.
Huijbregts, P. ; Feskens, E.J.M. ; Résénen, L. ; Fidanza, F. ; Nissinen, A. ; Menotti, A. ; Kromhout, D. - \ 1997
BMJ: British Medical Journal 315 (1997)7099. - ISSN 0959-8138 - p. 13 - 17.
OBJECTIVE: To investigate the association of dietary pattern and mortality in international data. DESIGN: Cohort study with 20 years' follow up of mortality. SETTING: Five cohorts in Finland, the Netherlands, and Italy. SUBJECTS: Population based random sample of 3045 men aged 50-70 years in 1970. MAIN OUTCOME MEASURES: Food intake was estimated using a cross check dietary history. In this dietary survey method, the usual food consumption pattern in the 6-12 months is estimated. A healthy diet indicator was calculated for the dietary pattern, using the World Health Organisation's guidelines for the prevention of chronic diseases. Vital status was verified after 20 years of follow up, and death rates were calculated. RESULTS: Dietary intake varied greatly in 1970 between the three countries. In Finland and the Netherlands the intake of saturated fatty acids and cholesterol was high and the intake of alcohol was low; in Italy the opposite was observed. In total 1796 men (59%) died during 20 years of follow up. The healthy diet indicator was inversely associated with mortality (P for trend < 0.05). After adjustment for age, smoking, and alcohol consumption, the relative risk in the group with the healthiest diet indicator compared with the group with the least healthy was 0.87 (95% confidence interval 0.77 to 0.98). Estimated relative risks were essentially similar within each country. CONCLUSIONS: Dietary intake of men aged 50-70 is associated with a 20 year, all cause mortality in different cultures. The healthy diet indicator is useful in evaluating the relation of mortality to dietary patterns.
|Alcohol, fish, fibre and antioxidant vitamins intake do not explain population differences in coronary heart diseases mortality.
Kromhout, D. ; Bloemberg, B.P.M. ; Feskens, E.J.M. ; Hertog, M.G.L. ; Menotti, A. ; Blackburn, H. - \ 1996
International Journal of Epidemiology 25 (1996). - ISSN 0300-5771 - p. 753 - 759.
Twenty-five-year prediction of stroke deaths in the seven countries study: the role of blood pressure and its changes.
Menotti, A. ; Blackburn, H. ; Jacobs Jr., D.R. ; Kromhout, D. ; Nissinen, A. ; Nedeljkovic, S. ; Buzina, R. ; Mohacek, I. ; Seccareccia, F. ; Giampaoli, S. ; Dontas, A. ; Aravanis, C. ; Toshima, H. - \ 1996
Stroke 27 (1996). - ISSN 0039-2499 - p. 381 - 387.
|Short term all-cause mortality and its determinants in elderly populations in Finland, The Netherlands and Italy, The FINE study.
Menotti, A. ; Kromhout, D. ; Nissinen, A. ; Giampaoli, S. ; Seccareccia, F. ; Feskens, E.J.M. ; Pekkanen, J. ; Tervahanta, M. - \ 1996
Preventive Medicine 25 (1996). - ISSN 0091-7435 - p. 319 - 327.
|Comparison of multivariate predictive power of major risk factors for coronary heart diseases in different countries: results from eight nations of the Seven Countries Study, 25-year follow-up
Menotti, A. ; Keys, A. ; Blackburn, H. ; Kromhout, D. ; Karvonen, M. ; Nissinen, A. ; Pekkanen, J. ; Punsar, S. ; Fidanza, F. ; Giampaoli, S. ; Seccareccia, F. ; Buzina, R. ; Mohacek, I. ; Nedeljkovic, S. ; Aravanis, C. ; Dontas, A. ; Toshima, H. ; Lanti, M. - \ 1996
Journal of Cardiovascular Risk 3 (1996). - ISSN 1350-6277 - p. 69 - 75.