Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function
    Rooden, Sanneke van; Buijs, Mathijs ; Vliet, Marjolein E. van; Versluis, Maarten J. ; Webb, Andrew G. ; Oleksik, Ania M. ; Wiel, Lotte van de; Middelkoop, Huub A.M. ; Blauw, Gerard Jan ; Weverling-Rynsburger, Annelies W.E. ; Goos, Jeroen D.C. ; Flier, Wiesje M. van der; Koene, Ted ; Scheltens, Philip ; Barkhof, Frederik ; Nieuwerth-van de Rest, Ondine ; Slagboom, P.E. ; Buchem, Mark A. van; Grond, Jeroen van der - \ 2016
    NMR in Biomedicine 29 (2016)9. - ISSN 0952-3480 - p. 1289 - 1294.
    AD pathology - Alzheimer's disease - brain imaging - cognition - human 7-T MRI - phase - subjective cognitive impairment

    Studies have suggested that, in subjects with subjective cognitive impairment (SCI), Alzheimer's disease (AD)-like changes may occur in the brain. Recently, an in vivo study has indicated the potential of ultra-high-field MRI to visualize amyloid-beta (Aβ)-associated changes in the cortex in patients with AD, manifested by a phase shift on T2*-weighted MRI scans. The main aim of this study was to investigate whether cortical phase shifts on T2*-weighted images at 7 T in subjects with SCI can be detected, possibly implicating the deposition of Aβ plaques and associated iron. Cognitive tests and T2*-weighted scans using a 7-T MRI system were performed in 28 patients with AD, 18 subjects with SCI and 27 healthy controls (HCs). Cortical phase shifts were measured. Univariate general linear modeling and linear regression analysis were used to assess the association between diagnosis and cortical phase shift, and between cortical phase shift and the different neuropsychological tests, adjusted for age and gender. The phase shift (mean, 1.19; range, 1.00–1.35) of the entire cortex in AD was higher than in both SCI (mean, 0.85; range, 0.73–0.99; p <0.001) and HC (mean, 0.94; range, 0.79–1.10; p <0.001). No AD-like changes, e.g. increased cortical phase shifts, were found in subjects with SCI compared with HCs. In SCI, a significant association was found between memory function (Wechsler Memory Scale, WMS) and cortical phase shift (β = –0.544, p = 0.007). The major finding of this study is that, in subjects with SCI, an increased cortical phase shift measured at high field is associated with a poorer memory performance, although, as a group, subjects with SCI do not show an increased phase shift compared with HCs. This increased cortical phase shift related to memory performance may contribute to the understanding of SCI as it is still unclear whether SCI is a sign of pre-clinical AD.

    Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly
    Brouwer, E.M. ; Nieuwerth-van de Rest, O. ; Tieland, C.A.B. ; Zwaluw, N.L. van der; Steegenga, W.T. ; Adam, J.J. ; Loon, L.J.C. van; Feskens, E.J.M. ; Groot, C.P.G.M. de - \ 2013
    In: Alzheimer’s Association International Conference. - - p. P883 - P883.
    Background Vitamin D deficiency is a common phenomenon all over the globe. Although vitamin D is best known for its role in calcium metabolism, recent studies suggest that it may also be favourable for cognitive processes. The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25(OH)D) and vitamin D intake with various domains of cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were mediated or modified by fasting plasma glucose (FPG) levels. Methods This cross-sectional study was conducted using data of 127 pre-frail and frail Dutch elderly. Associations of vitamin D with domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with global cognitive performance was explored by Poisson regression. Results Participants were on average 79 years old and had a mean MMSE score of 27.7±2.2. Serum 25(OH)D was positively associated with cognitive executive function (ß 0.007, P=0.01) and tended to be associated with information processing speed (ß 0.006, P=0.06), after adjustment for age, sex, BMI, educational level, alcohol intake, smoking, physical activity level and season of blood sampling. Glucose did neither modify nor mediate the association between serum 25(OH)D and domain specific cognitive performance. There was no association between vitamin D intake and cognitive performance. Conclusios This cross-sectional study suggests an association of serum 25(OH)D with domain specific cognitive performance, more specifically executive functioning. Whether this association is causal is yet to be demonstrated.
    Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression
    Brouwer, E.M. ; Nieuwerth-van de Rest, O. ; Tieland, C.A.B. ; Zwaluw, N.L. van der; Steegenga, W.T. ; Adam, J.J. ; Loon, L.J.C. van; Feskens, E.J.M. ; Groot, C.P.G.M. de - \ 2013
    Journal of the American Medical Directors Association 14 (2013)1. - ISSN 1525-8610 - p. 852.e9 - 852.e17.
    randomized controlled-trial - vitamin-d supplementation - placebo-controlled trial - parathyroid-hormone - insulin-resistance - double-blind - older women - risk-factors - us adults - population
    Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH] D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH) D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH) D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH) D was positively associated with executive functioning (beta 0.007, P=.01) and tended to be associated with information-processing speed (beta 0.006, P=.06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH) D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated. Copyright (C) 2013 - American Medical Directors Association, Inc.
    Het verre noorden dichterbij: is de Zuiderzeelijn een Europese of een nationale lijn?
    Snijders, M. ; Nieuwerth, B. ; Jaarsma, C.F. - \ 2003
    ROM Magazine 21 (2003)1/2. - ISSN 1380-7153 - p. 32 - 33.
    Horizonverkenning Noord-Nederland; een scenariostudie voor het landelijk gebied van Groningen, Friesland en Drenthe in 2030
    Nij Bijvank, R.A.F. ; Farjon, J.M.J. ; Noorman, L.N. ; Nieuwerth, K. ; Poel, K.R. de - \ 1998
    Wageningen : SC-DLO (Rapport 548) - 198 p.
    Directie Noord van het Ministerie van Landbouw, Natuurbeheer en Visserij heeft de behoefte aan een toekomstverkenning voor Noord-Nederland ter ondersteuning van de strategische beleidsvorming. Hiervoor zijn drie scenario's ontworpen: `Raamwerk', `Weefwerk' en `Marktwerk'. Van elk van de scenario's zijn de effecten op landbouw, natuur, landschap en recreatie bepaald. In `Raamwerk' zijn de ontwikkelingen grootschalig en zijn de functies gescheiden. Het aantal arbeidsplaatsen in de landbouw daalt met 5z% per jaar. Natuurontwikkeling vindt plaats in grote eenheden begeleid-natuurlijke natuur. Er ontstaat een duidelijke landschapstructuur op landsdelig niveau. `Weefwerk' zijn functies meer verweven en is het landschap kleinschaliger. Agrariërs hebben vaak nevenactiviteiten buiten de landbouw waardoor de landbouwbedrijven weinig in omvang toenemen en het aantal werkenden in de landbouw met slechts 1% per jaar daalt. Er ontstaan grote aaneengesloten gebieden waar natuurontwikkeling verweven is met andere functies. De duurzaamheid van dierpopulaties neemt in dit scenario het sterkst toe. Ook de verschillende landschapstypen blijven behouden of worden versterkt. In `Marktwerk' verdwijnt het markt- en prijsbeleid in de landbouw en stuurt de overheid de ruimtelijke ordening slechts op hoofdlijnen. De akkerbouw in Noord-Nederland moet plaatsmaken voor grote veehouderijbedrijven. Het aantal werkenden in de landbouw daalt ruimt 4% per jaar. Bestaande landschapswaarden worden in dit scenario het meest aangetast. Met name waterrecreatie neemt sterk toe, waardoor overdruksituaties rond de Friese Meren kunnen ontstaan.
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