Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    A lipase fusion feasts on fat
    Ruppert, Philip M.M. ; Kersten, Sander - \ 2020
    Journal of Biological Chemistry 295 (2020)10. - ISSN 0021-9258 - p. 2913 - 2914.

    The enzyme lipoprotein lipase (LPL) is responsible for breaking down triglycerides in the blood. Mutations in LPL cause a rare but debilitating disorder characterized by excessive plasma triglyceride levels for which treatment options are limited. Nimonkar et al. now present a fusion protein between LPL and its physiological transporter GBIHBP1 that is highly active and largely resistant to physiological inhibitors of LPL. Injecting this fusion protein effectively lowers plasma triglycerides in mice and represents a promising new approach for lowering triglycerides in patients with familial chylomicronemia syndrome.

    Genomic and physiological analyses of an indigenous strain, Enterococcus faecium 17OM39
    Ghattargi, Vikas C. ; Nimonkar, Yogesh S. ; Burse, Shaunak A. ; Davray, Dimple ; Kumbhare, Shreyas V. ; Shetty, Sudarshan A. ; Gaikwad, Meghana A. ; Suryavanshi, Mangesh V. ; Doijad, Swapnil P. ; Utage, Bhimashankar ; Sharma, Om Prakash ; Shouche, Yogesh S. ; Meti, Bharati S. ; Pawar, Shrikant P. - \ 2018
    Functional and Integrative Genomics 18 (2018)4. - ISSN 1438-793X - p. 385 - 399.
    Bile salt hydrolysis - Genome analysis - Indigenous probiotic - Probiotic genes - Serum resistance
    The human gut microbiome plays a crucial role in human health and efforts need to be done for cultivation and characterisation of bacteria with potential health benefits. Here, we isolated a bacterium from a healthy Indian adult faeces and investigated its potential as probiotic. The cultured bacterial strain 17OM39 was identified as Enterococcus faecium by 16S rRNA gene sequencing. The strain 17OM39 exhibited tolerance to acidic pH, showed antimicrobial activity and displayed strong cell surface traits such as hydrophobicity and autoaggregation capacity. The strain was able to tolerate bile salts and showed bile salt hydrolytic (BSH) activity, exopolysaccharide production and adherence to human HT-29 cell line. Importantly, partial haemolytic activity was detected and the strain was susceptible to the human serum. Genomics investigation of strain 17OM39 revealed the presence of diverse genes encoding for proteolytic enzymes, stress response systems and the ability to produce essential amino acids, vitamins and antimicrobial compound Bacteriocin-A. No virulence factors and plasmids were found in this genome of the strain 17OM39. Collectively, these physiological and genomic features of 17OM39 confirm the potential of this strain as a candidate probiotic.
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