Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Correction to: Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein
    Keating, Samuel T. ; Groh, Laszlo ; Thiem, Kathrin ; Bekkering, Siroon ; Li, Yang ; Matzaraki, Vasiliki ; Heijden, Charlotte D.C.C. van der; Puffelen, Jelmer H. van; Lachmandas, Ekta ; Jansen, Trees ; Oosting, Marije ; Bree, L.C.J. de; Koeken, Valerie A.C.M. ; Moorlag, Simone J.C.F.M. ; Mourits, Vera P. ; Diepen, Janna van; Stienstra, Rinke ; Novakovic, Boris ; Stunnenberg, Hendrik G. ; Crevel, Reinout van; Joosten, Leo A.B. ; Netea, Mihai G. ; Riksen, Niels P. - \ 2020
    Journal of Molecular Medicine 98 (2020). - ISSN 0946-2716

    The correct name of the 17th Author is presented in this paper. In the paragraph “Metabolic analysis” of the Method section “an XFp Analyzer” should be changed to “an XFe96 Analyzer”.

    Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein
    Keating, Samuel T. ; Groh, Laszlo ; Thiem, Kathrin ; Bekkering, Siroon ; Li, Yang ; Matzaraki, Vasiliki ; Heijden, Charlotte D.C.C. van der; Puffelen, Jelmer H. van; Lachmandas, Ekta ; Jansen, Trees ; Oosting, Marije ; Bree, L.C.J. de; Koeken, Valerie A.C.M. ; Moorlag, Simone J.C.F.M. ; Mourits, Vera P. ; Diepen, Janna van; Stienstra, Rinke ; Novakovic, Boris ; Stunnenberg, Hendrik G. ; Crevel, Reinout van; Joosten, Leo A.B. ; Netea, Mihai G. ; Riksen, Niels P. - \ 2020
    Journal of Molecular Medicine 98 (2020). - ISSN 0946-2716 - p. 819 - 831.
    Atherosclerosis - Cardiovascular disease - Diabetes complications - Glycolysis - Immunometabolism - Inflammation - Trained immunity

    Abstract: Stimulation of monocytes with microbial and non-microbial products, including oxidized low-density lipoprotein (oxLDL), induces a protracted pro-inflammatory, atherogenic phenotype sustained by metabolic and epigenetic reprogramming via a process called trained immunity. We investigated the intracellular metabolic mechanisms driving oxLDL-induced trained immunity in human primary monocytes and observed concomitant upregulation of glycolytic activity and oxygen consumption. In two separate cohorts of healthy volunteers, we assessed the impact of genetic variation in glycolytic genes on the training capacity of monocytes and found that variants mapped to glycolytic enzymes PFKFB3 and PFKP influenced trained immunity by oxLDL. Subsequent functional validation with inhibitors of glycolytic metabolism revealed dose-dependent inhibition of trained immunity in vitro. Furthermore, in vivo administration of the glucose metabolism modulator metformin abrogated the ability for human monocytes to mount a trained response to oxLDL. These findings underscore the importance of cellular metabolism for oxLDL-induced trained immunity and highlight potential immunomodulatory strategies for clinical management of atherosclerosis. Key messages: Brief stimulation of monocytes to oxLDL induces a prolonged inflammatory phenotype.This is due to upregulation of glycolytic metabolism.Genetic variation in glycolytic genes modulates oxLDL-induced trained immunity.Pharmacological inhibition of glycolysis prevents trained immunity.

    Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly
    Novaković, Romana ; Geelen, Anouk ; Ristić-Medić, Danijela ; Nikolić, Marina ; Souverein, Olga W. ; McNulty, Helene ; Duffy, Maresa ; Hoey, Leane ; Dullemeijer, Carla ; Renkema, Jacoba M.S. ; Gurinović, Mirjana ; Glibetić, Marija ; Groot, Lisette C.P.G.M. de; ’t Veer, Pieter van - \ 2018
    Annals of Nutrition & Metabolism 73 (2018)1. - ISSN 0250-6807 - p. 30 - 43.
    Adults-elderly - Dose-response - Folate - Intake-status

    Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

    Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
    Arts, Rob J.W. ; Novakovic, Boris ; Horst, Rob ter; Carvalho, Agostinho ; Bekkering, Siroon ; Lachmandas, Ekta ; Rodrigues, Fernando ; Silvestre, Ricardo ; Cheng, Shih Chin ; Wang, Shuang Yin ; Habibi, Ehsan ; Gonçalves, Luís G. ; Mesquita, Inês ; Cunha, Cristina ; Laarhoven, Arjan van; Veerdonk, Frank L. van de; Williams, David L. ; Meer, Jos W.M. van der; Logie, Colin ; O'Neill, Luke A. ; Dinarello, Charles A. ; Riksen, Niels P. ; Crevel, Reinout van; Clish, Clary ; Notebaart, Richard A. ; Joosten, Leo A.B. ; Stunnenberg, Hendrik G. ; Xavier, Ramnik J. ; Netea, Mihai G. - \ 2016
    Cell Metabolism 24 (2016)6. - ISSN 1550-4131 - p. 807 - 819.
    cholesterol metabolism - epigenetics - glutamine metabolism - glycolysis - trained immunity

    Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by β-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases. Furthermore, fumarate itself induced an epigenetic program similar to β-glucan-induced trained immunity. In line with this, inhibition of glutaminolysis and cholesterol synthesis in mice reduced the induction of trained immunity by β-glucan. Identification of the metabolic pathways leading to induction of trained immunity contributes to our understanding of innate immune memory and opens new therapeutic avenues.

    Socioeconomic factors are associated with folate and vitamin B12 intakes and related biomarkers concentrations in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence study
    Iglesia, I. ; Mouratidou, Th. ; González, M. ; Novakovic, R.N. ; Breidenassel, C. ; Jiménez-Pavón, D. ; Huybrechts, I. ; Geelen, A. ; Veer, P. van 't; Cavelaars, A.J.E.M. - \ 2014
    Nutrition Research 34 (2014)3. - ISSN 0271-5317 - p. 199 - 209.
    multiple source method - homocysteine levels - school-children - dietary habits - disease risk - food - indicators - behavior - helena - questionnaire
    Because socioeconomic factors (SEFs) may influence dietary quality and vitamin intakes, this study aimed to examine associations between socioeconomic factors and folate and vitamin B12 intakes as well as their related biomarkers in the Healthy Lifestyle in Europe by Nutrition in Adolescence study. Vitamin intakes were obtained from two 24-hour recalls in 2253 participants (47% males). Vitamin B biomarkers were assessed in a subsample of 977 participants (46% males). Socioeconomic factors were assessed by questionnaire, and 1-way analysis of covariance and linear regression analysis were applied. For males and females, mean intakes of folate were 211.19 and 177.18 µg/d, and for vitamin B12, 5.98 and 4.54 µg/d, respectively. Levels of plasma folate, red blood cell folate, serum B12, and holotranscobalamin were 18.74, 807.19, 330.64, and 63.04 nmol/L in males, respectively, and 19.13, 770.16, 377.9, and 65.63 nmol/L in females, respectively. Lower folate intakes were associated with several SEFs, including maternal and paternal education in both sexes. Regarding folate biomarkers, lower plasma folate intakes were associated with single/shared care in males and with lower paternal occupation in females. Lower vitamin B12 intakes were associated with almost all the studied SEFs, except paternal occupation in both sexes. In females, when considering vitamin B12 biomarkers, lower plasma vitamin B12 was associated with lower maternal education and occupation, and lower holotranscobalamin was associated with lower maternal education and lower paternal occupation. In conclusion, from the set of socioeconomic determinants studied in a sample of European adolescents, maternal education and paternal occupation were more consistently associated with folate and vitamin B12 intakes and biomarkers concentrations
    Socio-economic determinants of micronutrient intake and status in Europe: a systematic review
    Novakovic, R.N. ; Cavelaars, A.J.E.M. ; Geelen, A. ; Nikolic, M. ; Altaba, I.I. ; Vinas, B.R. ; Ngo, J. ; Golsorkhi, M. ; Medina, M. ; Brzozowska, A. ; Szczecinkska, A. ; Cock, D. de; Vansant, G. ; Renkema, J.M.S. ; Serra Majem, L. ; Moreno, L.A. ; Glibetic, M. ; Gurinovic, M. ; Veer, P. van 't; Groot, C.P.G.M. de - \ 2014
    Public Health Nutrition 17 (2014)5. - ISSN 1368-9800 - p. 1031 - 1045.
    life-style factors - food-habits - dietary-intake - maternal education - nutrient intake - population - nutrition - quality - adults - consumption
    OBJECTIVE: To provide the evidence base for targeted nutrition policies to reduce the risk of micronutrient/diet-related diseases among disadvantaged populations in Europe, by focusing on: folate, vitamin B12, Fe, Zn and iodine for intake and status; and vitamin C, vitamin D, Ca, Se and Cu for intake. DESIGN: MEDLINE and Embase databases were searched to collect original studies that: (i) were published from 1990 to 2011; (ii) involved >100 subjects; (iii) had assessed dietary intake at the individual level; and/or (iv) included best practice biomarkers reflecting micronutrient status. We estimated relative differences in mean micronutrient intake and/or status between the lowest and highest socio-economic groups to: (i) evaluate variation in intake and status between socio-economic groups; and (ii) report on data availability. SETTING: Europe. SUBJECTS: Children, adults and elderly. RESULTS: Data from eighteen publications originating primarily from Western Europe showed that there is a positive association between indicators of socio-economic status and micronutrient intake and/or status. The largest differences were observed for intake of vitamin C in eleven out of twelve studies (5-47 %) and for vitamin D in total of four studies (4-31 %). CONCLUSIONS: The positive association observed between micronutrient intake and socio-economic status should complement existing evidence on socio-economic inequalities in diet-related diseases among disadvantaged populations in Europe. These findings could provide clues for further research and have implications for public health policy aimed at improving the intake of micronutrients and diet-related diseases
    Systematic review of observational studies with dose-response meta-analysis between folate intake and folate status markers in adults and elderly
    Novakovic, R.N. ; Ristic-Medic, D. ; Nikolic, M. ; Souverein, O.W. ; Geelen, A. ; Dullemeijer, C. ; Mc Nulty, H. ; Duffy, M. ; Hoey, L. ; Gurinovic, M. ; Glibetic, M. ; Groot, C.P.G.M. de; Veer, P. van 't - \ 2013
    EURRECA—Estimating Zinc Requirements for Deriving Dietary Reference Values
    Lowe, N.M.M. ; Dykes, F.C. ; Skinner, A.L. ; Patel, S. ; Warthon-Medina, M. ; Decsi, T. ; Fekete, K. ; Souverein, O.W. ; Dullemeijer, C. ; Cavelaars, A.J.E.M. ; Serra-Majem, L. ; Nissensohn, M. ; Bel, S. ; Moreno, L.A. ; Hermoso, M. ; Vollhardt, C. ; Berti, C. ; Cetin, I. ; Gurinovic, M. ; Novakovic, R.N. ; Harvey, L.J. ; Collings, R. ; Hall-Moran, V. - \ 2013
    Critical Reviews in Food Science and Nutrition 53 (2013)10. - ISSN 1040-8398 - p. 1110 - 1123.
    current micronutrient recommendations - coronary-artery-disease - lung-cancer - serum zinc - genetic-polymorphism - stable-isotope - old patients - absorption - phytate - copper
    Zinc was selected as a priority micronutrient for EURRECA, because there is significant heterogeneity in the Dietary Reference Values (DRVs) across Europe. In addition, the prevalence of inadequate zinc intakes was thought to be high among all population groups worldwide, and the public health concern is considerable. In accordance with the EURRECA consortium principles and protocols, a series of literature reviews were undertaken in order to develop best practice guidelines for assessing dietary zinc intake and zinc status. These were incorporated into subsequent literature search strategies and protocols for studies investigating the relationships between zinc intake, status and health, as well as studies relating to the factorial approach (including bioavailability) for setting dietary recommendations. EMBASE (Ovid), Cochrane Library CENTRAL, and MEDLINE (Ovid) databases were searched for studies published up to February 2010 and collated into a series of Endnote databases that are available for the use of future DRV panels. Meta-analyses of data extracted from these publications were performed where possible in order to address specific questions relating to factors affecting dietary recommendations. This review has highlighted the need for more high quality studies to address gaps in current knowledge, in particular the continued search for a reliable biomarker of zinc status and the influence of genetic polymorphisms on individual dietary requirements. In addition, there is a need to further develop models of the effect of dietary inhibitors of zinc absorption and their impact on population dietary zinc requirements.
    EURRECA-Evidence-Based methodology for deriving micronutrient recommendations
    Dhonukshe-Rutten, R.A.M. ; Bouwman, J.H. ; Brown, K. ; Cavelaars, A.J.E.M. ; Collings, R. ; Grammatikaki, E. ; Groot, C.P.G.M. de; Gurinovic, M. ; Harvey, L.J. ; Hermoso, M. ; Hurst, R. ; Kremer, B. ; Ngo, J. ; Novakovic, R.N. ; Raats, M.M. ; Rollin, F. ; Serra-Majem, L. ; Souverein, O.W. ; Timotijevic, L. ; Veer, P. van 't - \ 2013
    Critical Reviews in Food Science and Nutrition 53 (2013)10. - ISSN 1040-8398 - p. 999 - 1040.
    dietary assessment methods - nutrient intake adequacy - nutrition policy - intake values - consumption surveys - pregnant-women - europe - health - food - patterns
    The EURopean micronutrient RECommendations Aligned (EURRECA) Network of Excellence explored the process of setting micronutrient recommendations to address the variance in recommendations across Europe. Work centered upon the transparent assessment of nutritional requirements via a series of systematic literature reviews and meta-analyses. In addition, the necessity of assessing nutritional requirements and the policy context of setting micronutrient recommendations was investigated. Findings have been presented in a framework that covers nine activities clustered into four stages: stage one “Defining the problem” describes Activities 1 and 2: “Identifying the nutrition-related health problem” and “Defining the process”; stage two “Monitoring and evaluating” describes Activities 3 and 7: “Establishing appropriate methods,” and “Nutrient intake and status of population groups”; stage three “Deriving dietary reference values” describes Activities 4, 5, and 6: “Collating sources of evidence,” “Appraisal of the evidence,” and “Integrating the evidence”; stage four “Using dietary reference values in policy making” describes Activities 8 and 9: “Identifying policy options,” and “Evaluating policy implementation.” These activities provide guidance on how to resolve various issues when deriving micronutrient requirements and address the methodological and policy decisions, which may explain the current variation in recommendations across Europe
    Socioeconomic differences in micronutrient intake and status in Europe
    Novakovic, R.N. - \ 2013
    Wageningen University. Promotor(en): Pieter van 't Veer; Lisette de Groot, co-promotor(en): Anouk Geelen; M. Gurinovic. - [S.l. : S.n. - ISBN 9789461735775 - 154
    sporenelementen - voedingsstoffenopname (mens en dier) - voedingstoestand - sociale economie - sociaal-economische positie - europa - vitaminen - trace elements - nutrient intake - nutritional state - socioeconomics - socioeconomic status - europe - vitamins

    The aim of this thesis was to evaluate micronutrient intake and status of socioeconomic disadvantaged populations, such as from Central and Eastern European (CEE) as compared to other European populations, and low socioeconomic status (SES) groups as compared to high SES groups within European countries. We addressed the micronutrients that have been prioritized because of their relevance for nutritional health by the EC-funded EURRECA Network of Excellence. Moreover, we assessed the association between folate intake and status which can be used in the process of setting folate DRVs.

    Micronutrient intake and status of CEE countries versus other European countries

    CEE countries have recently experienced rising income inequalities over a period of economic transition. There is some evidence that these reforms have been accompanied by health inequalities. Inadequacy in micronutrient intake and status may contribute to these inequalities. Because in more affluent Western European countries wide ranges in micronutrient intake and status are observed, we studied if low micronutrient intake and status levels are prevailing in CEE. The findings from this thesis signal no differences in micronutrient intake and status between CEE populations in comparison to those of other European regions with the exception of calcium intake in adults and iodine status in children that were lower in CEE than in other European regions. Since data from Western Europe indicate that inadequacies do exist among SES strata, more insight in the nutritional situation of lower SES populations in CEE and an understanding of both its determinants and consequences is needed. It is important to mention that evidence from grey literature added to that from open access sources. Fundamental to further studying of nutritional health in CEE, is suitable data. We underline the necessity for conducting nutritional surveillances on micronutrient intake and status in CEE as we have identified significant knowledge gaps for many life-stage groups.

    Differences in micronutrient intake between SES groups

    Considering that not enough studies have addressed the relationship between SES and micronutrient intake and status in their analyses of nutritional health, we performed a systematic review on this topic and we used data from the large European EPIC cohort to address that issue.

    To be able to conclude on socioeconomic, i.e. educational, occupational and income, inequalities associated with intake and status of prioritized micronutrients for all life stages in Europe, substantial knowledge gaps should be filled. Currently, data are mostly available for the intake of calcium, vitamin C and iron as collected from adults in Western European countries. When either of the above mentioned SES indicators was applied to estimate relative differences in micronutrient intake and status between the lowest and the highest SES category within one study, the results often, but not consistently, indicated a lower intake and/or status in low versus high SES groups. For example, in eight out of ten studies a lower intake for calcium intake was found with relative differences ranging from -2 to -14%. Similar patterns were found for vitamin C and iron: in eleven out of twelve studies relative differences ranged from -5 to -48% for vitamin C, whereas in nine of ten studies on iron relative differences went up to -14%. Studies on intake and/or status of folate, vitamin B12, zinc, iodine, and intake of vitamin D, selenium and copper were limited. Still, when differences were observed, it appeared that lower intake in low than in high SES groups was found except for vitamin B12 and zinc for which the findings were inconsistent.

    Furthermore, using education as a proxy for SES, we assessed differences in micronutrient intake between educational levels using the individual-participant data on European adults and elderly from the EPIC cohort. Based on data from 10 Western European countries it appeared that intake of calcium (except in France and a distinctive ‘health-conscious’ group in the UK), folate (except in Greece), and vitamin C was lower in the lowest than in the highest education groups: relative differences ranged up to 12, 13 and 23%, respectively. The intake of iron differed marginally, whereas the variation in intake of vitamins D and B12 was inconsistent. The observed association between educational level and intake of micronutrients was the same for men and women. Furthermore, differences in micronutrient intake were found to be larger between countries than between SES groups.

    With respect to SES differences in micronutrient intake and status, there are significant gaps in the open source literature for many life-stage groups in Europe, but particularly in CEE countries. There is a clear need for cross-country and within country comparative research and for the monitoring of trends in dietary intake across different SES groups and European countries.

    Relationship between folate intake and status to add complementary evidence for deriving folate dietary reference values (DRVs)

    DRVs are under continuous review and periodic revision as the cumulative evidence base and body of knowledge evolve. Folate is considered a public health priority micronutrient for which re-evaluation of DRVs is needed. For this micronutrient, a systematic review of observational studies on the relationship between intake and status was done followed by meta-analysis. The intake of folate was significantly associated with markers of folate status. The results of our meta-analysis showed that an average person with a folate intake of 100 µg/day has a serum/plasma folate status concentration that is 26% higher and a red blood cell folate status that is 21% higher than a person who has a folate intake of 50 µg/day; plasma homocysteine was found to be 16% lower. The difference between natural food folate and that from supplements and fortified foods (folic acid) significantly influenced the estimated relationship between folate intake and serum/plasma status. Associations were stronger when assessed as folate from the diet than as folate from diet and supplements. Dietary assessment method did not significantly influence the association, although pooled estimates were somewhat higher when FFQs were used as compared to 24-hour recalls combined with food records. To focus on the impact of poor intakes on related health outcomes, data modelling can be conducted to produce estimates for Average Nutrient Requirements. For this analysis datasets and statistical models developed within the EURRECA NoE are available and can be used.

    Overall, further research would benefit from methodologically comparable data on food intake in all age ranges, especially on so far understudied CEE populations. Both intakes obtained through diet and from supplements and fortified foods should be assessed. Monitoring of trends across SES strata should be done with standardized SES measurements that would also facilitate cross-country comparative research. The findings on the level and distribution of micronutrient intake and status could be used for development of food based dietary guidelines. To make them effective in meeting populations’ micronutrient needs, they should be created accounting for the country specific dietary patterns giving consideration to the socioeconomic context.

    Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network
    Novakovic, R.N. ; Cavelaars, A.J.E.M. ; Bekkering, G.E. ; Roman-Vinas, B. ; Ngo, J. ; Gurinovic, M. ; Glibetic, M. ; Golesorkhi, M. ; Warthon-Medina, M. ; Satalic, Z. ; Geelen, A. ; Serra Majem, L. ; Veer, P. van 't; Groot, C.P.G.M. de - \ 2013
    Public Health Nutrition 16 (2013)5. - ISSN 1368-9800 - p. 824 - 840.
    dietary habits - folate status - iodine-deficiency - serum zinc - nutritional-status - thyroid volume - food-habits - schoolchildren - population - prevalence
    Objective: To compare micronutrient intakes and status in Central and Eastern Europe (CEE) with those in other European countries and with reference values. Design: Review of the micronutrient intake/status data from open access and grey literature source
    Projected prevalence of inadequate nutrient intakes in Europe
    Vinas, B.R. ; Barba, L.R. ; Ngo, J. ; Gurinovic, M. ; Novakovic, R. ; Cavelaars, A.J.E.M. ; Groot, C.P.G.M. de; Veer, P. van 't; Matthys, C. ; Serra Majem, L. - \ 2011
    Annals of Nutrition & Metabolism 59 (2011)2-4. - ISSN 0250-6807 - p. 84 - 95.
    food-frequency questionnaires - health report 2004 - micronutrient intake - consumption surveys - dietary assessment - weighed records - nutrition - adequacy - recommendations - macronutrient
    Background: The purpose of this study was to analyze the prevalence of nutrient intake inadequacy in Europe, applying the Nordic Nutritional Recommendations in the context of the EURRECA Network of Excellence. Methods: Nutrient data was obtained from the European Nutrition and Health Report II. Those nutritional surveys using a validated food frequency questionnaire or diet history and a food diary/ register with at least 7 days of registers or with an adjustment for intraindividual variability were included. The nutrients analyzed were: vitamin C, vitamin D, vitamin B12, folic acid, calcium, iron, zinc, selenium, copper, and iodine. The estimated average requirement cut point was applied to estimate inadequacy. The Nordic and Institute of Medicine nutrient recommendations were used as references. Results: The mean prevalence of inadequacy was below 11% for zinc, iron, and vitamin B12 (only in the elderly), and it was 11–20% for copper in adults and the elderly and for vitamin B12 in adults and vitamin C in the elderly. The prevalence was above 20% for vitamin D, folic acid, calcium, selenium, and iodine in adults and the elderly and for vitamin C in adults. Conclusions: Vitamin C, vitamin D, folic acid, calcium, selenium, and iodine were the nutrients showing a higher prevalence of inadequate intakes in Europe
    Web-based tool on current micronutrient recommendations: importance and use
    Gurinovic, M. ; Cavelaars, A. ; Kadvan, A. ; Glibetic, M. ; Doets, E.L. ; Novakovic, R. ; Dhonukshe-Rutten, R.A.M. ; Veer, P. van 't; Groot, C.P.G.M. de - \ 2011
    Systematic review: socioeconomic and cultural determinants of low micronutrient intake and status within EURRECA network.
    Novakovic, R. ; Cavelaars, A. ; Renkema, M. ; Ngo, J. ; Vinas, B.R. ; Golsorkhi, M. ; Wharton Medina, M. ; Brzozowska, A. ; Szczecinska, A. ; Iglesia, I. ; Geelen, A. ; Cock, D. de; Veer, P. van 't; Groot, C.P.G.M. de; Serra Majem, L. ; Nikolic, M. ; Moreno, L.A. ; Matthys, C. ; Glibetic, M. - \ 2011
    Data availability for assessing adequacy of micronutrient intake in potentially vulnerable groups in Europe
    Novakovic, R.N. ; Gurinovic, M. ; Bekkering, G.E. ; Ristic Medic, D. ; Kadvan, A. ; Ngo-de la, J. ; Roman, B. ; Serra-Majem, L. ; Golsorkhi, M. ; Warthon-Medina, M. ; Matthys, C. ; Groot, C.P.G.M. de - \ 2010
    In: 3rd European Public Health Conference, Amsterdam, The Netherlands, 10 - 13 November, 2010. - - p. 125 - 125.
    To collect the best data for assessing nutritional adequacy in intake for EURRECA (Network of Excellence – EURopean micronutrient RECommendations Aligned) prioritized micronutrients in vulnerable groups (vitamin C, folate, vitamin B12, vitamin D, calcium, iron, zinc, iodine, selenium and copper) in Europe. Methods: The literature search was targeted towards identifying the nutritional intake data in low income and immigrant populations, pregnant and lactating women as these populations were poorly represented by European Nutrition Health Report and the inventory made by Flynn et al. Structured Medline searches (plus Embase and Cochrane searches for ‘lactation’) were performed from inception applying ‘lactation’ and ‘pregnancy’ as MeSH terms and ‘low income’ and ‘immigrant’ as text words. Original studies were included if 1) performed in European Union after 1990; 2) representative populations and n > 100. 3) dietary assessment method should be based on at least 3 days of collection or validated FFQs (Food Frequency Questionnaires) for the specified micronutrients. Results: With respect to EURRECA inclusion criteria, 5 studies have been found on low income and immigrant population and only 7 on pregnant women, whereas no data has been found on lactating women. Conclusion: To provide general evidence on current nutritional situation in Europe, micronutrient intake of low income and immigrant populations, pregnant and lactating women needs more attention as the data for these potentially vulnerable groups is lacking. Acknowledgement: The studies reported herein have been carried out within the EURRECA Network of Excellence (www.eurreca.org), financially supported by the Commission of the European Communities, specific Research, Technology and Development (RTD) Programme Quality of Life and Management of Living Resources, within the Sixth Framework Programme, contract no. 036196.
    Capacity development in food composition database management and nutritional research and education in Central and Eastern European, Middle Eastern and North African countries
    Gurinovic, M. ; Witthöft, C. ; Tepsic, J. ; Ranic, M. ; Hulshof, P.J.M. ; Hollman, P.C.H. ; Porubska, J. ; Gohar, A. ; Debeljak-Martacic, J. ; Petrovic-Oggiano, G. ; Novakovic, R.N. ; Glibetic, M. ; Oshaug, A. - \ 2010
    European Journal of Clinical Nutrition 64 (2010)S3. - ISSN 0954-3007 - p. S134 - S138.
    eurofir
    Background/Objectives: Capacity development (CD) in food and nutrition is much more than formal training and includes human resource development, and organisational, institutional and legal framework development with the aim of enhancing nutrition-relevant knowledge and skills to support infrastructural development. The goal of the European Food Information Resource (EuroFIR) Network of Excellence has been to develop and integrate food composition data throughout Europe. EuroFIR joined forces in CD with the United Nations (UN) University and UN System Standing Committee on Nutrition, the Network for Capacity Development in Nutrition in Central and Eastern Europe, the Central and Eastern European Countries Food Data Systems network and with the Middle East and North African Capacity Building Initiative. The aim of this paper is to discuss an inventory of the status of food composition databases (FCDBs) and the training needs of compilers in non-EuroFIR countries in Central and Eastern Europe (CEE) and in the Middle East and North Africa (MENA), and to present the CD achieved through EuroFIR and other network collaborations. Subjects/Methods: Two online questionnaires were created addressing the FCDB status and specific training needs in countries of the targeted regions. Data were collected during 2006-2008 and then analysed. Subsequently, CD activities were organised. Results: Contacts were established in 19 CEE and 7 MENA countries, of which several had national food composition tables, but no electronic versions. Education, training, workshops, networking and the sharing of experiences were uniformly requested. Subsequently, CD activities in EuroFIR were organised focussing on food composition courses, exchange visits, workshops and individual training for PhD students, junior scientists and other staff categories, as well as conferences linked to food composition research and food information. To facilitate CD activities, EuroFIR has signed a Memorandum of Understanding with the Czech Republic, Hungary, Slovenia, Croatia and Estonia. Conclusions: EuroFIR has created training activities that complement national activities. Collaboration with other networks has provided an overview of FCDB status and training needs, providing directions for CD activities in those countries. This provides a platform for new funding and further development and networking for CD, which would be conducive to European Commission objectives and public health strategies for CD. European Journal of Clinical Nutrition (2010) 64, S134-S138; doi:10.1038/ejcn.2010.224
    Nutri-RecQuest: a web-based search engine on current micronutrient recommendations
    Cavelaars, A.J.E.M. ; Kadvan, A. ; Doets, E.L. ; Tepsic, J. ; Novakovic, R.N. ; Dhonukshe-Rutten, R.A.M. ; Renkema, M. ; Glibetic, M. ; Bucchini, L. ; Matthys, C. ; Smith, R. ; Veer, P. van 't; Groot, C.P.G.M. de; Gurinovic, M. - \ 2010
    European Journal of Clinical Nutrition 64 (2010)S2. - ISSN 0954-3007 - p. S43 - S47.
    Background: The EURRECA (EURopean micronutrient RECommendations Aligned) Network of Excellence collated current micronutrient recommendations. A user-friendly tool, Nutri-RecQuest, was developed to allow access to the collated data and to create a database source for use in other nutritional software tools. Methods: Recommendations, that is, intakes of micronutrients sufficient to meet the requirements of the majority of healthy individuals of that population, from 37 European countries/organizations and eight key non-European countries/regions comprising 29 micronutrients were entered into a database. General information on the source of the recommendations, as well scientific background information, was added. Results: A user-friendly web-based interface was developed to provide efficient search, comparison, display, print and export functions. Conclusion: Easy access to existing recommendations through the web-based tool may be valuable for bodies responsible for setting recommendations, as well as for users of recommendations including scientists, policy makers, health professionals and industry. Adding related dietary reference values such as average nutrient requirements and upper limits may extend the utility of the tool
    Capacity development in nutrition in central and eastern Europe: collaboration between nutritional networks
    Gurinovic, M. ; Novakovic, R.N. ; Oshaug, A. ; Groot, C.P.G.M. de; Veer, P. van 't; Cavelaars, A.J.E.M. ; Hulshof, P.J.M. ; Glibetic, M. ; Pijls, L.T.J. ; Finglas, P.M. - \ 2009
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