Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Milieuschaamte, wat hebben we daar aan?
Hooge, Ilona de - \ 2019
A tracer-based method enables tracking of plasmodium falciparum malaria parasites during human skin infection
Winkel, Béatrice M.F. ; Korne, Clarize M. de; Oosterom, Matthias N. van; Staphorst, Diego ; Bunschoten, Anton ; Langenberg, Marijke C.C. ; Chevalley-Maurel, Séverine C. ; Janse, Chris J. ; Franke-Fayard, Blandine ; Leeuwen, Fijs W.B. van; Roestenberg, Meta - \ 2019
Theranostics 9 (2019)10. - ISSN 1838-7640 - p. 2768 - 2778.
Cell tracking - Malaria - Molecular Imaging - Skin - Sporozoites

Introduction: The skin stage of malaria is a vital and vulnerable migratory life stage of the parasite. It has been characterised in rodent models, but remains wholly uninvestigated for human malaria parasites. To enable in depth analysis of not genetically modified (non-GMO) Plasmodium falciparum (Pf) sporozoite behaviour in human skin, we devised a labelling technology (Cy5M2, targeting the sporozoite mitochondrion) that supports tracking of individual non-GMO sporozoites in human skin. Methods: Sporozoite labelling with Cy5M2 was performed in vitro as well as via the feed of infected Anopheles mosquitos. Labelling was validated using confocal microscopy and flow cytometry and the fitness of labelled sporozoites was determined by analysis of infectivity to human hepatocytes in vitro, and in vivo in a rodent infection model. Using confocal video microscopy and custom software, single-sporozoite tracking studies in human skin-explants were performed. Results: Both in vitro and in mosquito labelling strategies yielded brightly fluorescent sporozoites of three different Plasmodium species. Cy5M2 uptake colocalized with MitoTracker® green and could be blocked using the known Translocator protein (TSPO)-inhibitor PK11195. This method supported the visualization and subsequent quantitative analysis of the migration patterns of individual non-GMO Pf sporozoites in human skin and did not affect the fitness of sporozoites. Conclusions: The ability to label and image non-GMO Plasmodium sporozoites provides the basis for detailed studies on the human skin stage of malaria with potential for in vivo translation. As such, it is an important tool for development of vaccines based on attenuated sporozoites and their route of administration.

Nanoparticles reveal Extreme Size-Sorting and Morphologies in Complex Coacervate Superstructures
Hove, Jan Bart ten; Oosterom, Matthias N. van; Leeuwen, Fijs W.B. van; Velders, Aldrik H. - \ 2018
Scientific Reports 8 (2018)1. - ISSN 2045-2322

We here provide detailed insight in self-assembled complex coacervate systems exploiting gold nanoparticles for cryoTEM contrast. Nanoparticle-containing dendrimicelles are formed from fifth-generation dendrimer-encapsulated nanoparticles (DENs) and dendrimer-stabilized nanoparticles (DSNs). The complex coacervate structures self-organize in biconcave thin water layers into size-sorted monolayer superstructures. The embedded nanoparticles are a straightforward tool to visualize dendrimicelles and determine the aggregation number and polydispersity. The superstructure shows extreme size-sorting patterns which, contrary to related systems with higher generation dendrimers, consists not only of dendrimicelles but also much bigger complex coacervate nanoassemblies, such as vesicles.

A supramolecular approach for liver radioembolization
Spa, Silvia J. ; Welling, Mick M. ; Oosterom, Matthias N. van; Rietbergen, Daphne D.D. ; Burgmans, Mark C. ; Verboom, Willem ; Huskens, Jurriaan ; Buckle, Tessa ; Leeuwen, Fijs W.B. van - \ 2018
Theranostics 8 (2018)9. - ISSN 1838-7640 - p. 2377 - 2386.
Interventional radiology - Nanotechnology - Pre-targeting - Radioembolization - Supramolecular chemistry
Hepatic radioembolization therapies can suffer from discrepancies between diagnostic planning (scout-scan) and the therapeutic delivery itself, resulting in unwanted side-effects such as pulmonary shunting. We reasoned that a nanotechnology-based pre-targeting strategy could help overcome this shortcoming by directly linking pre-interventional diagnostics to the local delivery of therapy. Methods: The host-guest interaction between adamantane and cyclodextrin was employed in an in vivo pre-targeting set-up. Adamantane (guest)-functionalized macro albumin aggregates (MAA-Ad; d = 18 μm) and (radiolabeled) Cy5 and β-cyclodextrin (host)-containing PIBMA polymers (99mTc-Cy50.5CD10PIBMA39; MW ~ 18.8 kDa) functioned as the reactive pair. Following liver or lung embolization with (99mTc)-MAA-Ad or (99mTc)-MAA (controls), the utility of the pre-targeting concept was evaluated after intravenous administration of 99mTc-Cy50.5CD10PIBMA39. Results: Interactions between MAA-Ad and Cy50.5CD10PIBMA39 could be monitored in solution using confocal microscopy and were quantified by radioisotope-based binding experiments. In vivo the accumulation of the MAA-Ad particles in the liver or lungs yielded an approximate ten-fold increase in accumulation of 99mTc-Cy50.5CD10PIBMA39 in those organs (16.2 %ID/g and 10.5 %ID/g, respectively) compared to the control. Pre-targeting with MAA alone was shown to be only half as efficient. Uniquely, for the first time, this data demonstrates that the formation of supramolecular interactions between cyclodextrin and adamantane can be used to drive complex formation in the chemically challenging in vivo environment. Conclusion: The in vivo distribution pattern of the cyclodextrin host could be guided by the pre-administration of the adamantane guest, thereby creating a direct link between the scout-scan (MAA-Ad) and delivery of therapy.
Size-Sorting and Pattern Formation of Nanoparticle-Loaded Micellar Superstructures in Biconcave Thin Films
Hove, Jan Bart ten; Wang, Junyou ; Oosterom, Matthias N. van; Leeuwen, Fijs W.B. Van; Velders, Aldrik H. - \ 2017
ACS Nano 11 (2017)11. - ISSN 1936-0851 - p. 11225 - 11231.
Biconcave thin water layers represent a template to induce organization of supramolecular structures into ordered monolayers. Here we show how micelles form extensive micrometer-sized pseudo-2D superstructures that reveal size-sorting and geometric pattern formation, as shown by cryo-transmission electron microscopy (cryoTEM). Electron-rich gold particles inside the micelles facilitate direct visualization and determination of size, composition, and ordering of the micellar assemblies over multiple length scales. Some of the patterns observed show intriguing geometric patterns for superstructures, including Fibonacci-like, double-spiral domains that also appear in, for example, sunflower seed head patterns.
Fluorescent Lectins for Local in Vivo Visualization of Peripheral Nerves
KleinJan, G.H. ; Buckle, T. ; Willigen, D.M. van; Oosterom, M.N. van; Spa, S.J. ; Kloosterboer, H.E. ; Leeuwen, F.W.B. van - \ 2014
Molecules 19 (2014)7. - ISSN 1420-3049 - p. 9876 - 9892.
nervous-system - sentinel node - immunohistochemical localization - radical prostatectomy - sulfate proteoglycan - axonal-transport - guided surgery - identification - carcinoma - binding
Damage to peripheral nerves caused during a surgical intervention often results in function loss. Fluorescence imaging has the potential to improve intraoperative identification and preservation of these structures. However, only very few nerve targeting agents are available. This study describes the in vivo nerve staining capabilities of locally administered fluorescent lectin-analogues. To this end WGA, PNA, PHA-L and LEL were functionalized with Cy5 (lambda(ex) (max) 640 nm; lambda(em) (max) 680 nm). Transfer of these imaging agents along the sciatic nerve was evaluated in Thy1-YFP mice (n = 12) after intramuscular injection. Migration from the injection site was assessed in vivo using a laboratory fluorescence scanner and ex vivo via fluorescence confocal microscopy. All four lectins showed retrograde movement and staining of the epineurium with a signal-to-muscle ratio of around two. On average, the longest transfer distance was obtained with WGA-Cy5 (0.95 cm). Since WGA also gave minimal uptake in the lymphatic system, this lectin type revealed the highest potential as a migration imaging agent to visualize nerves.
Open data and beyond: Exploring existing open data projects to prepare a successful open data strategy
Loenen, B. van; Bregt, A.K. ; Bruinenberg, J. ; Castelein, W. ; Doorn, L. van; Juffermans, P. ; Kulk, S. ; Mourik, D. van; Oosterom, P. van; Ploeger, H. ; Quak, W. ; Vries, M. de; Zweistra, M. - \ 2012
Delft : OTB - 212 p.
Ontology spectrum for geological data interoperability
Ma, X. - \ 2011
University of Twente. Promotor(en): M. Molenaar, co-promotor(en): M.J. Kraak; P.J.M. van Oosterom; Arnold Bregt. - [S.l.] : S.n. - ISBN 9789061643234 - 184
geologie - datacommunicatie - gegevensbeheer - gegevensstructuren - gegevensanalyse - ontologieën - geology - data communication - data management - data structures - data analysis - ontologies
Comparison of sampling methods used for MRSA-classification of herds with breeding pigs
Broens, E.M. ; Graat, E.A.M. ; Engel, B. ; Oosterom, R.A.A. van; Giessen, A.W. van de; Wolf, P.J. van der - \ 2011
Veterinary Microbiology 147 (2011)3-4. - ISSN 0378-1135 - p. 440 - 444.
resistant staphylococcus-aureus
Since the first report on methicillin resistant Staphylococcus aureus (MRSA) CC398 in pigs, several countries have determined the prevalence of MRSA-positive pig herds using different sampling and laboratory techniques. The objective of the study was to compare three sampling methods for MRSA-classification of herds. Therefore, nasal swabs of pigs and environmental wipes were collected from 147 herds with breeding pigs. Per herd, laboratory examination was done on 10 pools of 6 nasal swabs (NASAL), 5 single environmental wipes (ENVSINGLE) and one pool of 5 environmental wipes (ENVPOOL). Large differences in apparent prevalence of MRSA-positive herds between methods were found: 19.1% for ENVPOOL, 53.1% for ENVSINGLE, and 70.8% for NASAL. Pairwise comparisons of methods resulted in relative sensitivities of 26.9% (ENVPOOL vs. NASAL), 34.6% (ENVPOOL vs. ENVSINGLE), and 72.1% (ENVSINGLE vs. NASAL) with relative specificities of respectively 100%, 98.6% and 93.0%. Cohen's kappa was respectively 0.18, 0.32 and 0.55, thus varying between very poor and moderate agreement. Examination of environmental wipes is an easy and non-invasive method to classify herds for MRSA. The number of environmental wipes needed depends on e.g. required detection limits and within-herd prevalence. In low prevalent herds (e.g. herds with
Bepaling bestand op de mosselpercelen in de Waddenzee najaar 2009. Onderzoeksproject Duurzame schelpdiervisserij (PRODUS). Deelproject 1A
Wijsman, J.W.M. ; Jol, J.G. ; Perdon, K.J. - \ 2010
Yerseke : IMARES (Rapport / IMARES Wageningen UR C050/10) - 50
schaal- en schelpdierenvisserij - mossels - inventarisaties - waddenzee - shellfish fisheries - mussels - inventories - wadden sea
Het totale mosselbestand op de percelen in de westelijke Waddenzee in het najaar van 2009 bedroeg bijna 47 miljoen kg (netto versgewicht). Van het totale bestand was 15 miljoen kg zaad en 28 miljoen kg consumptiemosselen. In 2008 was het totale bestand op de percelen ongeveer 30 miljoen kg. De meeste mosselen lagen in 2009 onder Terschelling in de perceelgebieden Oosterom, Balgen, Meep en Kabelgat en op de locaties Vlieter en Wolfshoek. Op Meep, Balgen en Vlieter ligt voornamelijk mosselzaad terwijl in Kabelgat en Wolfshoek voornamelijk consumptiemosselen liggen. In Oosterom bevindt zich een combinatie van zaadmosselen en consumptiemosselen.
Bepaling bestand op de mosselpercelen in de Waddenzee najaar 2008
Wijsman, J.W.M. ; Jol, J.G. - \ 2009
Yerseke : IMARES (Rapport / Wageningen IMARES C075/09) - 50
schaal- en schelpdierenvisserij - mosselteelt - mossels - mytilus edulis - voorraden - waddenzee - shellfish fisheries - mussel culture - mussels - stocks - wadden sea
A total stock of 30 million kg (net fresh weight) was estimated to be present at the culture plots in the Western part of the Wadden Sea in autumn 2008. The total stock could be divided into 12 million kg seed mussels and 16 million kg consumption mussels. In the same period in 2007 the total stock was 35 million kg. Most of the mussels in 2008 were present near Terschelling at the locations Oosterom, Balgen, Meep and Kabelgat. Seed mussels are mainly present at Meep and Balgen, while consumption mussels are mainly present at, Kabelgat en Oosterom
Project 8: prevalentieschatting en risicofactorenanalyse MRSA bij varkens
Broens, E.M. ; Graat, E.A.M. ; Jong, M.C.M. de; Meijerink, M. ; Broek, I.V.F. van den; Cleef, B.A.G.L. van; Huijsdens, X.W. ; Mevius, D.J. ; Oosterom, R.A.A. van; Wolf, P. de - \ 2009
In: Veegerelateerde MRSA: epidemiologie in dierlijke productieketens, transmissie naar de mens en karakterisatie van de kloon / Wagenaar, J.A., van de Giessen, A.W., Bilthoven : Rijksinstituut voor Volksgezondheid en Milieu (RIVM) (RIVM-rapport 330224001) - p. 49 - 68.
varkenshouderij - varkens - infectieziekten - staphylococcus aureus - volksgezondheid - ziekteprevalentie - ziektedistributie - zoönosen - pig farming - pigs - infectious diseases - staphylococcus aureus - public health - disease prevalence - disease distribution - zoonoses
Rapport over het voorkomen van MRSA op varkenshouderijen. Geconcludeerd wordt dat MRSA op veel zeugenbedrijven voorkomt en dat de prevalentie stijgt. Grote bedrijven hebben hebben een verhoogd risico. Het risico wordt daarnaast ook nog bepaald door een aantal factoren. Voor wat betreft de besmetting van MRSA door mensen wordt geconcludeerd dat mensen die intensief contact met MRSA-positieve varkens hebben een sterk verhoogd risico hebben om zelf MRSA-positief te zijn.
Influenza Virus
Koch, G. ; Fouchier, R.A.M. ; Koopmans, M. ; Fabri, T. - \ 2008
In: Zoonoses and Zoonotic Agents in Humans, Food, Animals and Feed in the Netherlands 2003-2006 / Valkenburgh, S., Oosterom, R., Stenvers, O., Aalten, M., Braks, M., Schimmer, B., van de Giessen, A., van Pelt, W., Nederland : RIVM (RIVM - Rapport 330152001) - ISBN 9789069601847 - p. 78 - 83.
Kosteneffectiviteit van alternatieve maatregelen voor bufferstroken in Nederland
Noij, G.J. ; Corre, W. ; Boekel, E.M.P.M. ; Oosterom, H.P. ; Middelkoop, J.C. van; Dijk, W. van; Clevering, O. ; Renaud, L.V. ; Bakel, P.J.T. van - \ 2008
Wageningen : Alterra (Effectiveness of buffer strips publication series 6) - 227
waterlopen - slootkanten - voedingsstoffen - uitspoelen - landbouwgrond - fosfaten - nitraten - akkerranden - bufferzones - oppervlaktewaterkwaliteit - begroeide stroken - streams - ditch banks - nutrients - leaching - agricultural land - phosphates - nitrates - field margins - buffer zones - surface water quality - vegetated strips
De kosteneffectiviteit is vergeleken van maatregelen om de oppervlaktewaterbelasting met nutriënten vanuit de landbouw terug te dringen. Aanleiding is de discussie over de (kosten)effectiviteit van onbemeste bufferstroken in Nederland. Van deze maatregel zijn alleen de kosten berekend, omdat de effectiviteit van bufferstroken nog onbekend is. Om te kunnen concurreren met alternatieve maatregelen, moeten bufferstroken in staat zijn om de nutriëntenvracht met enige kilos N en/of enige tienden van kilos P per ha per jaar te reduceren, wat overeenkomt met 10 tot 20% van de oorspronkelijke vracht.
Bepaling bestand op de mosselpercelen in de Waddenzee najaar 2007: onderzoeksproject Duurzame schelpdiervisserij (PRODUS), deelproject 1A
Wijsman, J.W.M. ; Jol, J.G. - \ 2008
Yerseke : IMARES (Rapport / Wageningen IMARES C022/08) - 48
mossels - mosselteelt - schaal- en schelpdierenvisserij - visbestand - waddenzee - monitoring - duurzaamheid (sustainability) - mussels - mussel culture - shellfish fisheries - fishery resources - wadden sea - sustainability
Het totale mosselbestand op de percelen in de westelijke Waddenzee in het najaar van 2007 bedroeg ruim 35 miljoen kg (netto versgewicht). De helft van het bestand bestaat uit zaad (17 miljoen kg) en er is ruim 15 miljoen kg aan consumptiemosselen aanwezig. In 2006 was het totale bestand op de percelen ongeveer 36 miljoen kg, maar toen was meer dan 80% van het bestand consumptiemosselen en lag er vrijwel geen zaad op de percelen. Belangrijke perceelblokken zijn Oosterom, Balgen, Wolfshoek, Kabelgat en Meep. Op de locaties Scheer, Texel, Boontjes, Slenk, Meep en Balgen ligt voornamelijk mosselzaad. De consumptiemosselen liggen voornamelijk in Wolfshoek, Kabelgat en Oosterom.
Antibiotic resistance
Mevius, D.J. ; Pelt, W. van - \ 2007
In: Zoonoses and zoonotic agents in humans, food, animals and feed in the Netherlands 2003-2006 / Valkenburgh, s., van Oosterom, R., Stenvers, O., Aalten, M., Braks, M., Schimmer, B., van de Giessen, A., van Pelt, W., Langelaar, M., Nederland : RIVM (RIVM rapport 330152001) - ISBN 9789069601847 - p. 42 - 44.
Koopmans, M. ; Kramps, J.A. ; Riel, A. van; Valkenburgh, S. ; Aalten, M. - \ 2007
In: Zoonoses and zoonotic agents in humans, food, animals and feed in the Netherlands 2003-2006 / Valkenburgh, S, van Oosterom, R., Stenvers, O., Aalten, M., Braks, M., Schimmer, B., van de Giessen, A., van Pelt, W., Langelaar, M., Bilthoven : RIVM (RIVM rapport 330152001) - ISBN 9789069601847 - p. 96 - 98.
Zijderveld, F.G. van - \ 2007
In: Zoonoses and Zoonotic Agents in Humans, Food, animals and Feed in the Netherlands 2003-2006 / Valkenburgh, S, van Oosterom, R., Aalten, M., Braks, M., Schimmer, B., Giessen, A., van Pelt, W., Langelaar, M., Bilthoven : RIVM (RIVM rapport 330152001) - ISBN 9789069601847 - p. 90 - 96.
The report 'Zoonoses and Zoonotic Agents in Humans, Food, Animals and Feed in The Netherlands 2003 - 2006' is based on data that is reported annually to the European Commission, in accordance with the Directive 2003/99/EC on the monitoring of zoonoses and zoonotic agents. They are supplemented with data from Dutch surveillance, monitoring and control programmes and relevant research projects concerning zoonoses and zoonotic agents by the different institutions that have contributed to the preparation of this report. The report also includes information on recent research on the antibiotic resistance of micro-organisms derived from human and animal material. Specific documentation and reports regarding the described programmes and research projects are available from the authors mentioned in the editorial list. The extended dataset on antimicrobial resistance and trends in the Netherlands has been published recently as a report: Maran 2003, 2004 and 2005.
Bronnen van nutriënten in het landelijke gebied : de bijdrage van landbouw aan oppervlaktewaterkwaliteit in perspectief
Bolt, F.J.E. van der; Oosterom, H.P. ; Hendriks, R.F.A. ; Groenendijk, P. - \ 2007
Wageningen : Alterra (Alterra-rapport 1483) - 53
platteland - voedingsstoffen - oppervlaktewater - waterverontreiniging - fosfaten - nitraten - nederland - landbouw - bemesting - rural areas - nutrients - surface water - water pollution - phosphates - nitrates - netherlands - agriculture - fertilizer application
De bijdrage van de bronnen van stikstof en fosfor in het landelijke gebied aan de belasting op het oppervlaktewater is gekwantificeerd met indicatieve berekeningen met STONE versie 2.1
Specifying and implementing constraints in GIS - with examples from a Geo-Virtual Reality system
Louwsma, J. ; Zlatanova, S. ; Lammeren, R.J.A. van; Oosterom, P. van - \ 2006
Geoinformatica : an international journal on advances of computer science for geographic information systems 10 (2006)4. - ISSN 1384-6175 - p. 531 - 550.
Constraints are important elements of every modelling process, but until now they have been treated in an ad hoc manner, depending on the specific application domain and the capabilities of the tools used. In GIS and GeoVR applications, constraints are conditions which always have to be valid (true) within the model populated with real geographic object instances. This paper argues that constraints should form a systematic part of the object class definition, similar to other aspects of the definition, viz. attributes, methods and relationships. Also, the implementation of constraints in all GIS and GeoVR subsystems (at front-end, database and exchange (I/O) level) should be derived automatically from the constraints specified by the framework. The paper therefore puts forward a framework for modelling constraints comprising (1) a classification and clarification of constraints, (2) a formal description using the unified modelling language/object constraint language (UML/OCL) and (3) implementation characteristics. The components of the framework are illustrated and applied to SALIX-2, a geo-virtual reality (GeoVR) landscape modelling system
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