Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Acute effects of ∆9-tetrahydrocannabinol (THC) on resting state brain function and their modulation by COMT genotype
Bossong, Matthijs G. ; Hell, Hendrika H. van; Schubart, Chris D. ; Saane, Wesley van; Iseger, Tabitha A. ; Jager, Gerry ; Osch, Matthias J.P. van; Jansma, J.M. ; Kahn, René S. ; Boks, Marco P. ; Ramsey, Nick F. - \ 2019
European Neuropsychopharmacology 29 (2019)6. - ISSN 0924-977X - p. 766 - 776.
Arterial spin labelling - Cannabis - Catechol-methyl-transferase (COMT) - Delta9-tetrahydrocannabinol (THC) - Resting state connectivity - Salience

Cannabis produces a broad range of acute, dose-dependent psychotropic effects. Only a limited number of neuroimaging studies have mapped these effects by examining the impact of cannabis on resting state brain neurophysiology. Moreover, how genetic variation influences the acute effects of cannabis on resting state brain function is unknown. Here we investigated the acute effects of ∆9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, on resting state brain neurophysiology, and their modulation by catechol-methyl-transferase (COMT) Val158Met genotype. Thirty-nine healthy volunteers participated in a pharmacological MRI study, where we applied Arterial Spin Labelling (ASL) to measure perfusion and functional MRI to assess resting state connectivity. THC increased perfusion in bilateral insula, medial superior frontal cortex, and left middle orbital frontal gyrus. This latter brain area showed significantly decreased connectivity with the precuneus after THC administration. THC effects on perfusion in the left insula were significantly related to subjective changes in perception and relaxation. These findings indicate that THC enhances metabolism and thus neural activity in the salience network. Furthermore, results suggest that recruitment of brain areas within this network is involved in the acute effects of THC. Resting state perfusion was modulated by COMT genotype, indicated by a significant interaction effect between drug and genotype on perfusion in the executive network, with increased perfusion after THC in Val/Met heterozygotes only. This finding suggests that prefrontal dopamine levels are involved in the susceptibility to acute effects of cannabis.

Induction of trained innate immunity in human monocytes by bovine milk and milk-derived immunoglobulin G
Splunter, Marloes van; Osch, Thijs L.J. van; Brugman, Sylvia ; Savelkoul, Huub F.J. ; Joosten, Leo A.B. ; Netea, Mihai G. ; Neerven, R.J.J. van - \ 2018
Nutrients 10 (2018)10. - ISSN 2072-6643
Bovine IgG - Bovine lactoferrin - Dietary compounds - Innate immune memory - Monocytes - Raw bovine milk - Trained immunity

Innate immune memory, also termed “trained immunity” in vertebrates, has been recently described in a large variety of plants and animals. In most cases, trained innate immunity is induced by pathogens or pathogen-associated molecular patterns (PAMPs), and is associated with long-term epigenetic, metabolic, and functional reprogramming. Interestingly, recent findings indicate that food components can mimic PAMPs effects and induce trained immunity. The aim of this study was to investigate whether bovine milk or its components can induce trained immunity in human monocytes. To this aim, monocytes were exposed for 24 h to β-glucan, Toll-like receptor (TLR)-ligands, bovine milk, milk fractions, bovine lactoferrin (bLF), and bovine Immunoglobulin G (bIgG). After washing away the stimulus and a resting period of five days, the cells were re-stimulated with TLR ligands and Tumor necrosis factor (TNF-) and interleukin (IL)-6 production was measured. Training with β-glucan resulted in higher cytokine production after TLR1/2, TLR4, and TLR7/8 stimulation. When monocytes trained with raw milk were re-stimulated with TLR1/2 ligand Pam3CSK4, trained cells produced more IL-6 compared to non-trained cells. Training with bIgG resulted in higher cytokine production after TLR4 and TLR7/8 stimulation. These results show that bovine milk and bIgG can induce trained immunity in human monocytes. This confirms the hypothesis that diet components can influence the long-term responsiveness of the innate immune system.

BAFF augments IgA2 and IL-10 production by TLR7/8 stimulated total peripheral blood B cells
Hartog, C.G. den; Osch, Thijs L.J. van; Vos, Martijn ; Meijer, B. ; Savelkoul, H.F.J. ; Neerven, R.J.J. van; Brugman, S. - \ 2018
European journal of immunology 48 (2018)2. - ISSN 0014-2980 - p. 283 - 292.
Class-switching of B cells to IgA can be induced via both T-cell-dependent and T-cell-independent mechanisms. IgA is most predominantly produced mucosally and is important for combating infections and allergies. In contrast to mice, humans have two forms of IgA; IgA1 and IgA2 with diverse tissue distribution. In early life, IgA levels might be sub-optimal especially during the fall season when bacterial and viral infections are more common. Therefore, we investigated using human B cells whether T-cell-independent factors -promoting cell survival, class switching and immunoglobulin secretion- BAFF, APRIL, IL-10 and retinoic acid can boost IgA production in the context of viral or bacterial infection. To this end total and naive peripheral blood B cells were stimulated with these factors for 6 days in the presence or absence of TLR7/8 agonist R848 (mimicking viral infection) or TLR9 agonist CpG-ODN (mimicking bacterial infection). We show that BAFF significantly augments IgA2 production in TLR7/8 stimulated mature, but not naïve B cells. In addition, BAFF augments IL-10 production and viability in TLR7/8 and TLR9 stimulated mature B cells. These data warrant further investigation of its role in immune regulation both in the periphery and mucosal tissues in early life or during disease.
Social media, hoe mensen daarmee communiceren
Aarts, N. - \ 2011
In: Basisboek Social Media / van Osch, D., van Zijl, R., Den Haag : Boom Lemma - ISBN 9789059317048 - p. 45 - 71.
Evidence for involvement of the insula in the psychotropic effects of THC in humans: a double-blind, randomized pharmacological MRI study
Hell, H.H. van; Bossong, M.G. ; Jager, G. ; Kristo, G. ; Osch, M.J.P. ; Zelaya, F. ; Kahn, R.S. ; Ramsey, N.F. - \ 2011
International Journal of Neuropsychopharmacology 14 (2011)10. - ISSN 1461-1457 - p. 1377 - 1388.
cerebral-blood-flow - low-frequency fluctuation - central-nervous-system - resting-state fmri - neural-basis - anterior insula - healthy-volunteers - marijuana smoking - functional mri - cannabis use
The main reason for recreational use of cannabis is the ‘high’, the primary psychotropic effect of ¿9-tetrahydrocannabinol (THC). This psychoactive compound of cannabis induces a range of subjective, physical and mental reactions. The effect on heart rate is pronounced and complicates bloodflow-based neuroimaging of psychotropic effects of THC. In this study we investigated the effects of THC on baseline brain perfusion and activity in association with the induction of ‘feeling high’. Twenty-three subjects participated in a pharmacological MRI study, where we applied arterial spin labelling (ASL) to measure perfusion, and resting-state functional MRI to assess blood oxygen level-dependent signal fluctuation as a measure of baseline brain activity. Feeling high was assessed with a visual analogue scale and was compared to the imaging measures. THC increased perfusion in the anterior cingulate cortex, superior frontal cortex, and insula, and reduced perfusion in the post-central and occipital gyrus. Baseline brain activity was altered, indicated by increased amplitude of fluctuations in resting-state functional MRI signal after THC administration in the insula, substantia nigra and cerebellum. Perfusion changes in frontal cortex were negatively correlated with ratings of feeling high, suggesting an interaction between cognitive control and subjective effects of THC. In conclusion, an acute THC challenge altered baseline brain perfusion and activity, especially in frontal brain areas involved in cognitive and emotional processes, and the insula, associated with interoceptive awareness. These changes may represent the THC-induced neurophysiological correlates of feeling high. The alterations in baseline brain perfusion and activity also have relevance for studies on task-related effects of THC on brain function.
Biofilm formation and genotyping of Staphylococcus aureus bovine mastitis isolates: Evidence for lack of penicillin-resistance in Agr-type II strains
Melchior, M.B. ; Osch, M.H.J. ; Graat, R. ; Duijkeren, E. van; Mevius, D.J. ; Nielen, M. ; Gaastra, W. ; Fink, J. - \ 2009
Veterinary Microbiology 137 (2009)1-2. - ISSN 0378-1135 - p. 83 - 89.
polysaccharide intercellular adhesin - quaternary ammonium-compounds - sequence element is256 - somatic-cell count - antimicrobial susceptibility - genetic-variability - epidermidis - milk - infections - protein
The increasing evidence for a role of biofilm formation in bovine mastitis caused by Staphylococcus aureus led to further investigations on biofilm formation by S. aureus isolates from mastitis in two growth media (TSBg and bovine milk serum). The ability of 99 S. aureus strains that were recently isolated or obtained from a culture collection (historical strains) to form biofilm, in both growth media as well as the correlation of biofilm formation with the presence of the ica-, bap-, and IS257 genes are described. These genes have been correlated with biofilm formation by human S. aureus isolates. All strains were also genotyped with respect to their Agr-type and -subtype, and for the presence of the antibiotic resistance genes blaZ and smr by PCR. The prevalence of the Agr-types and the investigated genes and their correlation with biofilm formation were statistically evaluated. The Agr-type of a strain had a marked effect on the biofilm formation, by that strain, however in contrast to human isolates no significant effect of ica- and IS257 genes on biofilm formation was observed. The bap gene was not found in any of the investigated strains. The presence of biofilm related genes showed a high correlation with the Agr-type of the strains. The data give evidence for a very strong correlation of Agr-type I strains and penicillin-resistance in the bovine S. aureus mastitis strains; none of the Agr-type II strains was found to harbor penicillin-resistance genes. These data indicate that the most prevalent Agr-types in S. aureus bovine mastitis, Agr-type I and II, can be regarded as different subspecies, with different abilities for the formation of biofilm in bovine milk serum. The very high correlation between Agr-type II and penicillin-susceptibility strongly suggests that these strains are not able to accommodate blaZ genes
Fyto-V eindrapport, Ontwikkelen van fytotherapie als middel bij het reduceren van en/of behandelen van dierziekten
Groot, M.J. ; Noordam, M.Y. ; Kleter, G.A. ; Asseldonk, A.G.M. ; Kleijer-Ligtenberg, E. ; Halkes, S.B.A. ; Fink-Gremmels, J. ; Osch, H.H. van - \ 2009
Wageningen : RIKILT (Rapport / RIKILT, Instituut voor Voedselveiligheid 2008.010) - 1009
medicinale planten - veeartsenijkunde - vee - diervoedering - voedertoevoegingen - voedersupplementen - wetgeving - regelingen - nederland - europa - medicinal plants - veterinary medicine - livestock - animal feeding - feed additives - feed supplements - legislation - regulations - netherlands - europe
This report describes the current legislation in the Netherlands, Europe and in a number of other important countries regarding the use of herbs in animals and in humans; the bottlenecks in current legislation as noticed by the registration authorities, the industry and the animal production sector; the recommendations of the project group to solve these bottlenecks.
Genotyping and biofilm formation in different growth media of Staphylococcus aureus bovine mastitis isolates: evidence for lack of penicillin-resistance in Agr-type II strains
Melchior, M.B. ; Osch, M.H.J. ; Graat, R. ; Duijkeren, E. van; Mevius, D.J. ; Nielen, M. ; Gaastra, W. ; Fink-Gremmels, J. - \ 2008
Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion
Smeets, P.A.M. ; Vidarsdottir, S. ; Graaf, C. de; Stafleu, A. ; Osch, M.J.P. ; Viergever, M.A. ; Pijl, H. ; Grond, J. van der - \ 2007
American Journal of Physiology. Endocrinology and Metabolism 293 (2007)3. - ISSN 0193-1849 - p. E754 - E758.
glucagon-like peptide-1 - central-nervous-system - reduces food-intake - postprandial glucose - sensory stimulation - insulin release - functional mri - blood-glucose - sweet taste - body-weight
Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion. Am J Physiol Endocrinol Metab 293: E754-E758, 2007. First published June 12, 2007; doi:10.1152/ajpendo.00231.2007. - We previously showed that hypothalamic neuronal activity, as measured by the blood oxygen level-dependent ( BOLD) functional MRI signal, declines in response to oral glucose intake. To further explore the mechanism driving changes in hypothalamic neuronal activity in response to an oral glucose load, we here compare hypothalamic BOLD signal changes subsequent to an oral vs. an intravenous (iv) glucose challenge in healthy humans. Seven healthy, normal-weight men received four interventions in random order after an overnight fast: 1) ingestion of glucose solution ( 75 g in 300 ml) or 2) water ( 300 ml), and 3) iv infusion of 40% glucose solution (0.5 g/kg body wt, maximum 35 g) or 4) infusion of saline (0.9% NaCl, equal volume). The BOLD signal was recorded as of 8 min prior to intervention ( baseline) until 30 min after. Glucose infusion was associated with a modest and transient signal decline in the hypothalamus. In contrast, glucose ingestion was followed by a profound and persistent signal decrease despite the fact that plasma glucose levels were almost threefold lower than in response to iv administration. Accordingly, glucose ingestion tended to suppress hunger more than iv infusion ( P <0.1). We infer that neural and endocrine signals emanating from the gastrointestinal tract are critical for the hypothalamic response to nutrient ingestion.
Effect of satiety on brain activation during chocolate tasting in men and women
Smeets, P.A.M. ; Graaf, C. de; Stafleu, A. ; Osch, M.J.P. ; Nievelstein, R.A.J. ; Grond, J. van der - \ 2006
American Journal of Clinical Nutrition 83 (2006)6. - ISSN 0002-9165 - p. 1297 - 1305.
human orbitofrontal cortex - sensory-specific satiety - gender-differences - liquid food - eating behavior - sex-differences - stimuli - appetite - humans - fmri
Background:The brain plays a crucial role in the decision to eat, integrating multiple hormonal and neural signals. A key factor controlling food intake is selective satiety, ie, the phenomenon that the motivation to eat more of a food decreases more than does the motivation to eat foods not eaten. Objective:We investigated the effect of satiation with chocolate on the brain activation associated with chocolate taste in men and women. Design:Twelve men and 12 women participated. Subjects fasted overnight and were scanned by use of functional magnetic resonance imaging while tasting chocolate milk, before and after eating chocolate until they were satiated. Results:In men, chocolate satiation was associated with increased taste activation in the ventral striatum, insula, and orbitofrontal and medial orbitofrontal cortex and with decreased taste activation in somatosensory areas. Women showed increased taste activation in the precentral gyrus, superior temporal gyrus, and putamen and decreased taste activation in the hypothalamus and amygdala. Sex differences in the effect of chocolate satiation were found in the hypothalamus, ventral striatum, and medial prefrontal cortex (all P <0.005). Conclusions:Our results indicate that men and women differ in their response to satiation and suggest that the regulation of food intake by the brain may vary between the sexes. Therefore, sex differences are a covariate of interest in studies of the brain's responses to food.
Functional MRI of human hypothalamic responses following glucose ingestion
Smeets, P.A.M. ; Graaf, C. de; Stafleu, A. ; Osch, M.J.P. ; Grond, J. van der - \ 2005
NeuroImage 24 (2005)2. - ISSN 1053-8119 - p. 363 - 368.
phase insulin release - multi-unit activity - cephalic phase - food-intake - sensory stimulation - secretion - brain - men - taste - rats
The hypothalamus is intimately involved in the regulation of food intake, integrating multiple neural and hormonal signals. Several hypothalamic nuclei contain glucose-sensitive neurons, which play a crucial role in energy homeostasis. Although a few functional magnetic resonance imaging (fMRI) studies have indicated that glucose consumption has some effect on the neuronal activity levels in the hypothalamus, this matter has not been investigated extensively yet. For instance, dose-dependency of the hypothalamic responses to glucose ingestion has not been addressed. We measured the effects of two different glucose loads on neuronal activity levels in the human hypothalamus using fMRI. After an overnight fast, the hypothalamus of 15 normal weight men was scanned continuously for 37 min. After 7 min, subjects ingested either water or a glucose solution containing 25 or 75 g of glucose. We observed a prolonged decrease of the fMRI signal in the hypothalamus, which started shortly after subjects began drinking the glucose solution and lasted for at least 30 min. Moreover, the observed response was dose-dependent: a larger glucose load resulted in a larger signal decrease. This effect was most pronounced in the upper anterior hypothalamus. In the upper posterior hypothalamus, the signal decrease was similar for both glucose loads. No effect was found in the lower hypothalamus. We suggest a possible relation between the observed hypothalamic response and changes in the blood insulin concentration
Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories
Smeets, P.A.M. ; Graaf, C. de; Stafleu, A. ; Osch, M.J.P. ; Grond, J. van der - \ 2005
American Journal of Clinical Nutrition 82 (2005)5. - ISSN 0002-9165 - p. 1011 - 1016.
phase insulin release - sensory stimulation - food-intake - nutritional implications - glucose-ingestion - body-weight - stress - secretion
BACKGROUND: Evidence exists that beverages do not trigger appropriate anticipatory physiologic responses, such as cephalic phase insulin release. Therefore, it is of interest to elucidate the food properties necessary for triggering adaptive responses. Previously, we found a prolonged dose-dependent decrease in the hypothalamic functional magnetic resonance imaging signal after ingestion of a glucose solution. OBJECTIVES: The aims of the present study were to measure the effects of sweet taste and energy content on the hypothalamic response to glucose ingestion and to measure the concomitant changes in blood glucose and insulin concentrations. DESIGN: Five healthy, normal-weight men participated in a randomized crossover design trial. The subjects were scanned 4 times for 37 min on separate days with functional magnetic resonance imaging. After 7 min, they ingested 1 of the following 4 stimuli (300 mL of each): water (control), a glucose solution, an aspartame (sweet taste) solution, or a maltodextrin (nonsweet carbohydrate) solution. RESULTS: Glucose ingestion resulted in a prolonged and significant signal decrease in the upper hypothalamus (P <0.05). Water, aspartame, and maltodextrin had no such effect. Glucose and maltodextrin ingestions resulted in similar increases in blood glucose and insulin concentrations. However, only glucose triggered an early rise in insulin concentrations. Aspartame did not trigger any insulin response. CONCLUSIONS: Our findings suggest that both sweet taste and energy content are required for a hypothalamic response. The combination of sweet taste and energy content could be crucial in triggering adaptive responses to sweetened beverages
Fermentation characteristics of the caecal contents of broiler chickens fed fine- and coarse particle diets.
Williams, B.A. ; Osch, L.J.M. van; Kwakkel, R.P. - \ 1997
In: WPSA (UK Branch) Spring Meeting, 26-27 march - p. 49 - 49.
Effect van deeltjesgrootte (grof vs. fijn voer) op de fermentatiekinetiek in de ceca van vleeskuikens.
Kwakkel, R.P. ; Osch, L.J.M. van; Williams, B.A. ; Poel, A.F.B. van der - \ 1997
In: Proc. 22e studiedag voor Nederlandstalige Voedingsonderzoekers, Gent, België - p. 56 - 57.
Vegetatie en fauna van de Vallei van het Veen (Vlieland) voorafgaande aan begrazing
Wingerden, W.K.R.E. van; Stumpel, A.H.P. ; Osch, J.W.G. van - \ 1993
Wageningen : IBN-DLO (IBN - rapport 042)
wildbescherming - flora - fauna - wild - bescherming - conservering - plantengemeenschappen - vegetatie - onderzoek - biogeografie - begrazing - bedrijfsvoering - natuurbescherming - nederland - friesland - nederlandse waddeneilanden - wildlife conservation - wildlife - protection - conservation - plant communities - vegetation - research - biogeography - grazing - management - nature conservation - netherlands - dutch wadden islands
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