Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection
    Graat, J.M. ; Schouten, E.G. ; Heijnen, M.L. ; Kok, F.J. ; Pallast, E.G. ; Greeff, S.C. de; Dorigo-Zetsma, J.W. - \ 2003
    Journal of Clinical Epidemiology 56 (2003)12. - ISSN 0895-4356 - p. 1218 - 1223.
    polymerase-chain-reaction - tract infections - mycoplasma-pneumoniae - chlamydia-pneumoniae - syncytial virus - influenza - etiology - illness - pcr
    Background and Objective: Community-based elderly studies concerning microbiology of acute respiratory infections are scarce. Data on subclinical infections are even totally absent, although asymptomatic persons might act as a source of respiratory infections. Methods: In a 1-year community-based study, we prospectively investigated the possible virologic cause of acute respiratory infections in 107 symptomatic case episodes and 91 symptom-free control periods. Participants, persons greater than or equal to60 years, reported daily the presence of respiratory symptoms in a diary. Virologic assessment was performed by polymerase chain reaction (PCR) and serology. Results: In 58% of the case episodes a pathogen was demonstrated, the most common being rhinoviruses (32%), coronaviruses (17%), and influenzaviruses (7%). The odds ratio for demonstrating a virus in cases with symptoms vs. controls without symptoms was 30.0 (95% confidence interval 10.2-87.6). In 4% of the symptom-free control periods a virus was detected. Conclusion: This study supports the importance of rhinovirus infections in community-dwelling elderly persons, whereas asymptomatic elderly persons can also harbor pathogens as detected by PCR, and thus might be a source of infection for their environment. (C) 2003 Elsevier Inc. All rights reserved.
    Immunity in frail elderly : a randomized controlled trial of exercise and enriched foods
    Chin A Paw, M.J.M. ; Jong, N. de; Pallast, E.G.M. ; Kloek, G. ; Schouten, E.G. ; Kok, F.J. - \ 2000
    Medicine and Science in Sports and Exercise 32 (2000)12. - ISSN 0195-9131 - p. 2005 - 2011.
    To examine the effects of 17-wk physical exercise and enriched foods on cellular immune response (CIR) in frail elderly. METHODS: A total of 112 independently living, frail elderly men and women (mean age 79.2 /- 5.9) received: twice weekly comprehensive, moderate intensity, progressive group exercise (group A, N = 26); daily enriched foods (group B, N = 31); both (group C, N = 29); or neither (group D, N = 26). Exercises focused on skills training. Foods were enriched with micronutrients with a high prevalence of deficiency in older people (at 25-100% the RDA). A social program and identical regular foods were offered as a control. CIR was measured by delayed-type hypersensitivity skin test response (DTH) against seven recall antigens expressed as the total number of positive responses and sum of diameters of all positive responses. RESULTS: No independent or interactive effect of enriched foods was observed. Therefore, exercise (groups A C) was compared with no exercise (groups B D). Nonexercising subjects showed an average decline of 0.5 responses compared with an unchanged responsiveness among exercising subjects (difference = 0.5, 95% CI: 0.04-0.89, P = 0.03 adjusted for baseline DTH, activity level, and micronutrient status). Nonexercising subjects had a larger decline in the sum of diameters of all positive responses than exercising subjects but the difference did not reach significance (adjusted difference = 2.1 mm, 95% CI:-1.0-4.8). CONCLUSION: Exercise may prevent or slow the age-related decline in immune response. Micronutrient enriched foods showed no effect. As infectious diseases can have debilitating or even fatal consequences for the elderly, prevention of the age-related decline in CIR could significantly improve their quality of life.
    Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons
    Pallast, E.G. ; Schouten, E.G. ; Waart, F.G. de; Fonk, H.C. ; Doekes, G. ; Blomberg, B.M. von; Kok, F.J. - \ 1999
    American Journal of Clinical Nutrition 69 (1999). - ISSN 0002-9165 - p. 1273 - 1281.
    Effect van vitamine E op cellulaire immuunrespons bij ouderen.
    Pallast, E.G.M. ; Waart, F.G. de; Fonk, H.C.M. - \ 1998
    Voeding 59 (1998). - ISSN 0042-7926 - p. 31 - 31.
    Effect van vitamine E op cellulaire immuunrespons bij ouderen.
    Pallast, E.G.M. ; Schouten, E.G. ; Waart, F.G. de - \ 1998
    Tijdschrift voor sociale gezondheidszorg 4 (1998). - ISSN 0920-0517 - p. 2.4 - 2.4.
    Plasma antioxidant vitaminestatus en immuunrespons bij ouderen.
    Pallast, E.G.M. ; Schouten, E.G. ; Waart, F.G. de; Kok, F.J. - \ 1997
    Tijdschrift voor sociale geneeskunde 75 (1997). - ISSN 0040-7607 - p. 46 - 46.
    Plasma antioxidant vitamin status and cellular immune response in the elderly.
    Pallast, E.G.M. ; Schouten, E.G. ; Waart, F.G. de; Kok, F.J. - \ 1997
    In: Report of Int. Conf. Series on Nutr. and Health Promotions: Conf. on Nutr. and Immunity. Atlanta, Georgia, U.S.A. - p. 97 - 97.
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