Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis
Wijnker, Erik ; Harashima, Hirofumi ; Müller, Katja ; Parra-Nuñez, Pablo ; Bastiaan de Snoo, C. ; Belt, Jose van de; Dissmeyer, Nico ; Bayer, Martin ; Pradillo, Monica ; Schnittger, Arp - \ 2019
Proceedings of the National Academy of Sciences of the United States of America 116 (2019)25. - ISSN 0027-8424 - p. 12534 - 12539.
Class - Cross-over interference - Crossovers - Cyclin-dependent kinase - Meiosis - Meiotic recombination

Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.

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