Gold and silver dichroic nanocomposite in the quest for 3D printing the Lycurgus cup
Kool, Lars ; Dekker, Floris ; Bunschoten, Anton ; Smales, Glen J. ; Pauw, Brian R. ; Velders, Aldrik H. ; Saggiomo, Vittorio - \ 2020
Beilstein Journal of Nanotechnology 11 (2020). - ISSN 2190-4286 - p. 16 - 23.
3D printing - Dichroism - Lycurgus cup - Nanocomposite
The Lycurgus cup is an ancient glass artefact that shows dichroism as it looks green when a white light is reflected on it and a red colouring appears when a white light is transmitted through it. This peculiar dichroic effect is due to silver and gold nanoparticles present in the glass. In this research we show the synthesis of dichroic silver nanoparticles and their embedding in a 3D printable nanocomposite. The addition of gold nanoparticles to the silver nanoparticle composite, gave a 3D printable nanocomposite with the same dichroism effect of the Lycurgus cup.
GO-FRESH: Valorisatie kansrijke oplossingen voor een robuuste zoetwatervoorziening : Rendabel en duurzaam watergebruik in een zilte omgeving
Veraart, J.A. ; Oude Essink, G. ; Pauw, P. ; Baaren, E. van; Zuurbier, K. ; Louw, P. de; MacAteer, E. ; Schoot, M. van der; Groot, N. ; Cappon, H. ; Waterloo, M. ; Hu-a-ng, K. ; Groen, M. - \ 2018
Deltares - 187 p.
Groundwater salinity mapping of the Belgian coastal zone to improve local freshwater storage availability
Vandevelde, Dieter ; Baaren, Esther Van; Delsman, Joost ; Karaoulis, Marios ; Oude Essink, Gualbert ; Louw, Perry de; Vermaas, Tommer ; Pauw, Pieter ; Kleine, Marco De; Thofte, Sara ; Teilmann, Rasmus ; Walraevens, Kristine ; Camp, Marc Van; Dominique, Huits ; Dabekaussen, Willem ; Gunnink, Jan ; Vandenbohede, Alexander - \ 2018
In: 25th Salt Water Intrusion Meeting (SWIM 2018). - EDP Sciences (E3S Web of Conferences ) - 6 p.
In the European TOPSOIL project, countries around the North Sea are searching for solutions for climate related threats. They explore the possibilities of using the topsoil layer to solve current and future water challenges. The main objective is to improve the climate resilience of the water management of the topsoil and shallow aquifers in the North Sea region. TOPSOIL is supported by the Interreg VB North Sea Region program in line with priority 3 of the program: 'Sustainable North Sea Region, protecting against climate change and preserving the environment'. The Belgian part of this project, called FRESHEM for GO-FRESH Vlaanderen ('FREsh Salt groundwater distribution by Helicopter ElectroMagnetic survey for Geohydrological Opportunities FRESH water supply'), focuses on mapping the salinity distribution of groundwater using airborne electromagnetics and aims to look into a number of measures that could increase the availability of freshwater for agriculture in the polder area. Two pilot projects will evaluate the possibilities for freshwater storage and aims to specify what measures can be taken to achieve this. Together with the other water users and water managers, The Flanders Environment Agency wants to prepare a plan for the realization of one or more pilot projects that can improve the availability of freshwater.
Fresh Water Lens Persistence and Root Zone Salinization Hazard Under Temperate Climate
Stofberg, Sija F. ; Oude Essink, G.H.P. ; Pauw, Pieter S. ; Louw, Perry G.B. de; Leijnse, Anton ; Zee, Sjoerd E.A.T.M. van der - \ 2017
Water Resources Management 31 (2017)2. - ISSN 0920-4741 - p. 689 - 702.
Fresh water lens - Root zone salinization - Salinity - Simple model - salinization - fresh water - models - water supply - coastal areas - zoutgehalte - verzilting - zoet water - modellen - watervoorziening - kustgebieden
In low lying deltaic areas in temperate climates, groundwater can be brackish to saline at shallow depth, even with a yearly rainfall excess. For primary production in horticulture, agriculture, and terrestrial nature areas, the fresh water availability may be restricted to so-called fresh water lenses: relatively thin pockets of fresh groundwater floating on top of saline groundwater. The persistence of such fresh water lenses, as well as the quantity and quality of surface water is expected to be under pressure due to climate change, as summer droughts may intensify in North-West Europe. Better understanding through modelling of these fresh water resources may help anticipate the impact of salinity on primary production. We use a simple model to determine in which circumstances fresh water lenses may disappear during summer droughts, as that could give rise to enhanced root zone salinity. With a more involved combination of expert judgement and numerical simulations, it is possible to give an appraisal of the hazard that fresh water lenses disappear for the Dutch coastal regions. For such situations, we derive an analytical tool for anticipating the resulting salinization of the root zone, which agrees well with numerical simulations. The provided tools give a basis to quantify which lenses are in hazard of disappearing periodically, as well as an impression in which coastal areas this hazard is largest. Accordingly, these results and the followed procedure may assist water management decisions and prioritization strategies leading to a secure/robust fresh water supply on a national to regional scale.
Compounds against ralstonia pickettii for use in the treatment of insulin resistance, and method of diagnosis of insulin resistance
Nieuwdorp, Max ; Vos, W.M. de; Pauw, E.S.D. de - \ 2016
Octrooinummer: WO2016030500, gepubliceerd: 2016-03-03.
The invention therefore provides a compound effective against Ralstonia pickettii for use in the treatment or prevention of insulin resistance, obesity or type II diabetes of a subject. Preferably, said compound is selected from the group consisting of an antibiotic effective against Ralstonia pickettii, an immunogenic compound capable of producing a protective immune response in a subject, and an antibody which specifically binds to Ralstonia pickettii or a binding fragment thereof. The invention further provides an in vitro method of diagnosis or prediction of insulin resistance, obesity or type II diabetes in a subject, comprising determining the presence of Ralstonia pickettii or the presence of an antibody which specifically binds to Ralstonia pickettii in a test sample of said subject. In another aspect, the invention provides the use of an antibody binding specifically to an antigen of Ralstonia pickettii, a Ralstonia pickettii cell, and/or a nucleic acid hybridizing under stringent conditions to a nucleic acid from Ralstonia pickettii in a method according to the invention. The invention further provides the use of a kit comprising said antibody, a nucleic acid as defined in above, and optionally comprising a Ralstonia pickettii bacteria or a nucleic acid or protein thereof, a further reagent or a conventional kit component.
Saltwater upconing due to cyclic pumping by horizontal wells in freshwater lenses
Pauw, P.S. ; Zee, S.E.A.T.M. van der; Leijnse, A. ; Essink, Gualbert Oude H.P. - \ 2016
Groundwater 54 (2016)4. - ISSN 0017-467X - p. 521 - 531.
This article deals with the quantification of saltwater upconing below horizontal wells in freshwater lenses using analytical solutions as a computationally fast alternative to numerical simulations. Comparisons between analytical calculations and numerical simulations are presented regarding three aspects: (1) cyclic pumping; (2) dispersion; and (3) finite horizontal wells in a finite domain (a freshwater lens). Various hydrogeological conditions and pumping regimes within a dry half year are considered. The results show that the influence of elastic and phreatic storage (which are not taken into account in the analytical solutions) on the upconing of the interface is minimal. Furthermore, the analytical calculations based on the interface approach compare well with numerical simulations as long as the dimensionless interface upconing is below 1/3, which is in line with previous studies on steady pumping. Superimposing an analytical solution for mixing by dispersion below the well over an analytical solution based on the interface approach is appropriate in case the vertical flow velocity around the interface is nearly constant but should not be used for estimating the salinity of the pumped groundwater. The analytical calculations of interface upconing below a finite horizontal well compare well with the numerical simulations in case the distance between the horizontal well and the initial interface does not vary significantly along the well and in case the natural fluctuation of the freshwater lens is small. In order to maintain a low level of salinity in the well during a dry half year, the dimensionless analytically calculated interface upconing should stay below 0.25.
Increasing a freshwater lens below a creek ridge using a controlled artificial recharge and drainage system: a case study in the Netherlands
Pauw, P.S. ; Baaren, Esther S. van; Visser, Martijn ; Louw, Perry G.B. de; Oude Essink, Gualbert H.P. - \ 2015
Hydrogeology Journal 23 (2015)7. - ISSN 1431-2174 - p. 1415 - 1430.
Artificial recharge - Coastal aquifers - Creek ridge - Salt-water/fresh-water relations - The Netherlands
A controlled artificial recharge and drainage (CARD) system was used to increase freshwater lenses below creek ridges to increase freshwater supply. Creek ridges are typical geomorphological features that lie up to 2 m higher than the surroundings in the reclaimed tidal flat landscape of the southwestern Netherlands. The 5–30-m thick freshwater lenses below the creek ridges are a vital source for irrigation, as the groundwater and surface waters are predominantly saline. However, freshwater supply from these lenses is commonly not sufficient to meet the irrigation demand, which leads to crop damage. The CARD system was tested in the field and the development of the freshwater lens was monitored during the period May 2013 to May 2014. Numerical models, which were used to investigate a long-term effect of the CARD system, predicted that below the center of the creek ridge, the 13–15-m thick freshwater lens increased 6–8 m within 10 years. The total volumetric increase of the freshwater lens was about 190,000 m3 after 10 years, which was about 40 % of the total recharge (natural and artificial recharge). From this increased freshwater lens, up to three times more water can be extracted using horizontal wells, compared to the initial size of the freshwater lens. A higher water table in the CARD system leads to a thicker freshwater lens but a lower storage efficiency. A lower water table has the opposite effect.
Low-resolution modeling of dense drainage networks in confining layers
Pauw, P.S. ; Zee, S.E.A.T.M. van der; Leijnse, A. ; Delsman, J.R. ; Louw, P.G.B. de; Lange, W.J. de; Oude Essink, G.H.P. - \ 2015
Groundwater 53 (2015)5. - ISSN 0017-467X - p. 771 - 781.
grondwaterstroming - watervoerende lagen - modellen - klimaatverandering - groundwater flow - aquifers - models - climatic change - aquifer - simulation - intrusion - seepage - florida - system - field - flow
Groundwater-surface water (GW-SW) interaction in numerical groundwater flow models is generally simulated using a Cauchy boundary condition, which relates the flow between the surface water and the groundwater to the product of the head difference between the node and the surface water level, and a coefficient, often referred to as the “conductance.” Previous studies have shown that in models with a low grid resolution, the resistance to GW-SW interaction below the surface water bed should often be accounted for in the parameterization of the conductance, in addition to the resistance across the surface water bed. Three conductance expressions that take this resistance into account were investigated: two that were presented by Mehl and Hill (2010) and the one that was presented by De Lange (1999). Their accuracy in low-resolution models regarding salt and water fluxes to a dense drainage network in a confined aquifer system was determined. For a wide range of hydrogeological conditions, the influence of (1) variable groundwater density; (2) vertical grid discretization; and (3) simulation of both ditches and tile drains in a single model cell was investigated. The results indicate that the conductance expression of De Lange (1999) should be used in similar hydrogeological conditions as considered in this paper, as it is better taking into account the resistance to flow below the surface water bed. For the cases that were considered, the influence of variable groundwater density and vertical grid discretization on the accuracy of the conductance expression of De Lange (1999) is small.
Field and model investigations of freshwater lenses in coastal aquifers
Pauw, P.S. - \ 2015
Wageningen University. Promotor(en): Sjoerd van der Zee, co-promotor(en): G.H.P. Oude Essink; Toon Leijnse. - Wageningen : Wageningen University - ISBN 9789462572928 - 158
kustgebieden - watervoorziening - zoet water - wateropslag - geohydrologie - modellen - zuidwest-nederland - zeeland - coastal areas - water supply - fresh water - water storage - geohydrology - models - south-west netherlands - zeeland
A major problem of sustaining freshwater supply from freshwater lens is the invasion of saline groundwater into a fresh groundwater body. In many coastal areas saltwater intrusion has led to well closure and reduced freshwater supply. Furthermore, in the future saltwater intrusion is expected to increase due to sea level rise, climate change, land subsidence, and increasing population density in coastal areas. In the Netherlands, these stresses will also have a severe impact on the fresh coastal groundwater reserves. In view of this, a research project within the Dutch research program ’Knowledge for Climate’ was defined in 2010, aimed at: 1. Improving the insight into the modeling of freshwater lenses. 2. Defining measures to increase freshwater supply from freshwater lenses. In this thesis the results of four studies related to these objectives are presented.
Controlling the dopant dose in silicon by mixed-monolayer doping
Ye, L. ; Pujari, S.P. ; Zuilhof, H. ; Kudernac, T. ; Jong, M.P. de; Wiel, W.G. van der; Huskens, J. - \ 2015
ACS Applied Materials and Interfaces 7 (2015)5. - ISSN 1944-8244 - p. 3231 - 3236.
organic monolayers - surfaces
Molecular monolayer doping (MLD) presents an alternative to achieve doping of silicon in a nondestructive way and holds potential for realizing ultrashallow junctions and doping of nonplanar surfaces. Here, we report the mixing of dopant-containing alkenes with alkenes that lack this functionality at various ratios to control the dopant concentration in the resulting monolayer and concomitantly the dopant dose in the silicon substrate. The mixed monolayers were grafted onto hydrogen-terminated silicon using well-established hydrosilylation chemistry. Contact angle measurements, X-ray photon spectroscopy (XPS) on the boron-containing monolayers, and Auger electron spectroscopy on the phosphorus-containing monolayers show clear trends as a function of the dopant-containing alkene concentration. Dynamic secondary-ion mass spectroscopy (D-SIMS) and Van der Pauw resistance measurements on the in-diffused samples show an effective tuning of the doping concentration in silicon.
Improving welfare of cod and haddock by adapting current practices in trawl fishing
Bokkers, E.A.M. ; Pauw, W.H. ; Veldhuizen, L.J.L. - \ 2014
In: Proceedings of the 6th International Conference on the Assessment of Animal Welfare at Farm and Group Level (WAFL 2014). - Wageningen, The Netherlands : Wageningen Academic Publishers - ISBN 9789086862474 - p. 207 - 207.
Fish are sentient beings and therefore animal welfare can be considered an issue in fisheries. Current trawl fishing on cod and haddock leads to exhaustion, injuries and suffocation of the fish, indicators of impaired welfare. Fishermen might be able to implement changes in trawling to improve the welfare of cod and haddock, but they prioritize their economic balance. The aim of this study was to identify improvement options for welfare of cod and haddock during the most welfare impairing phase of catch without economic losses or extra investments to the fishermen. Fish caught in wild capture fisheries have lived a natural life prior to catch. This natural life is interrupted when they are caught and killed by fishermen. In trawl fishing, 5 phases can be distinguished that might affect fish welfare: pretrawl, drifting, towing, surfacing, and landing and processing. Data of a Norwegian trawler was used as a case. Severity of each phase was assessed by studying the contribution to stress and injuries. Also duration of each phase was analysed. In the pretrawl phase (1-12 min), fish swim away from an approaching trawler. During drifting (
Regional scale impact of tidal forcing on groundwater flow in unconfined coastal aquifers
Pauw, P.S. ; Oude Essink, G.H.P. ; Leijnse, A. ; Vandenbohede, A. ; Groen, J. ; Zee, S.E.A.T.M. van der - \ 2014
Journal of Hydrology 517 (2014). - ISSN 0022-1694 - p. 269 - 283.
grondwaterstroming - kustgebieden - watervoerende lagen - groundwater flow - coastal areas - aquifers - sea-water intrusion - saline groundwater - fresh - beaches - discharge - dynamics - lenses - table - zone
This paper considers the impact of tidal forcing on regional groundwater flow in an unconfined coastal aquifer. Numerical models are used to quantify this impact for a wide range of hydrogeological conditions. Both a shallow and a deep aquifer are investigated with regard to three dimensionless parameter groups that determine the groundwater flow to a large extent. Analytical expressions are presented that allow for a quick estimate of the regional scale effect of tidal forcing under the same conditions as used in the numerical models. Quantitatively, the results in this paper are complementary to previous studies by taking into account variable density groundwater flow, dispersive salt transport and a seepage face in the intertidal area. Qualitatively, the results are in line with previous investigations. The time-averaged hydraulic head at the high tide mark increases upon a decrease of each of the three considered dimensionless parameter groups: R (including the ratio of the hydraulic conductivity and the precipitation excess), a (the slope of the intertidal area) and AL (the ratio of the width of the fresh water lens and the tidal amplitude). The relative change of the location and the hydraulic head of the groundwater divide, which together characterize regional groundwater flow, increase as a and AL decrease, but decrease as R decreases. The difference between the analytical solutions and numerical results is small. Therefore, the presented analytical solutions can be used to estimate the bias that is introduced in a numerical model if tidal forcing is neglected. The results should be used with caution in case of significant wave forcing, as this was not considered.
Balancing supply and demand of fresh water under increasing drought and salinisation in the Netherlands
Jeuken, A. ; Beek, E. ; Duinen, R. ; Veen, A. van der; Bocalon, A. ; Delsman, J. ; Pauw, P.S. ; Oude Essink, G. ; Zee, S.E.A.T.M. van der; Stofberg, S.F. ; Zuurbier, K. ; Stuyfzand, P. ; Appelman, W. ; Creusen, R. ; Paalman, M. ; Katschnig, D. ; Rozema, J. ; Mens, M. ; Kwakkel, J. ; Thissen, W. ; Veraart, J.A. ; Tolk, L. ; Vries, A. de - \ 2012
Utrecht : Knowledge for Climate - 42
watervoorziening - zoet water - klimaatverandering - droogte - verzilting - water supply - fresh water - climatic change - drought - salinization
The latest climate impact assessments show that climate change will cause an increasing mismatch between demand and supply of fresh water in many densely populated deltas around the world. Recent studies for the Netherlands show that the current water supply strategy is not climate proof in the long-run. Therefore, a future ‘climate proof’ fresh water supply is national priority on the Dutch water policy agenda
Groundwater salinisation in the Wadden Sea area of the Netherlands: quantifying the effects of climate change, sea level rise and anthropogenic interferences
Pauw, P.S. ; Louw, P.G.B. de; Oude Essink, G.H.P. - \ 2012
Netherlands journal of geosciences 91 (2012)3. - ISSN 0016-7746 - p. 373 - 383.
geohydrologie - zoet water - verzilting - noord-holland - nederlandse waddeneilanden - geohydrology - fresh water - salinization - noord-holland - dutch wadden islands
Hydrogeological research in coastal areas has gained considerable attention over the last decades due to increasing stresses on fresh groundwater resources. Fundamental groundwater flow and solute transport analyses remain essential for a concise understanding of the governing processes that lead to salinisation of fresh groundwater resources. However, the challenge of modern research is the application and quantification of these processes in real world cases. In this context, deltaic areas are amongst the most difficult study areas as they often have a complex groundwater salinity distribution. The Wadden Sea area in the northern part of the Netherlands is an example of such an area. We quantified salt water intrusion and salinisation of groundwater flow systems in two representative case studies in the Wadden Sea area, using the density dependent groundwater flow and transport code MOCDENS3D. The results indicate that sea-level rise and autonomous processes will cause severe salinisation in the future, especially in the low polder areas close to the sea. In addition, we show that enhanced land subsidence due to salt exploitation accelerates this process. Salinisation can be mitigated to some extent by raising surface water levels in polders and by creating saline groundwater collection areas that maintain a low controlled water level.
|Balancing supply and demand of fresh water under increasing drought and salinisation in the Netherlands. Midterm Assessment 2012, Theme 2 Climate Proof Fresh Water Supply, KfC report number 58/2012
Jeuken, A. ; Veraart, J.A. ; Pauw, P. ; Zee, S. van der; Stofberg, S. - \ 2012
Wageningen : Alterra
Opties voor een klimaatbestendige zoetwatervoorziening in Laag Nederland, tussentijds integratierapport
Jeuken, A. ; Hoogvliet, M. ; Beek, E. van; Baaren, E. van; Duinen, R. ; Veen, A. van der; Linde, A. van der; Delsman, J. ; Pauw, P. ; Oude Essink, G. ; Zee, S. van der; Stofberg, S. ; Appelman, W. ; Cruesen, R. ; Paalman, M. ; Katschnig, D. ; Rozema, J. ; Mens, M. ; Kwakkel, J. ; Veraart, J.A. - \ 2012
KvK - 86
watervoorziening - zoet water - waterbeschikbaarheid - landbouwgronden - tuinbouwgronden - natuurgebieden - zelfvoorziening - zelfvoorzieningslandbouw - verzilting - regionale planning - water supply - fresh water - water availability - agricultural soils - horticultural soils - natural areas - self sufficiency - subsistence farming - salinization - regional planning
Dit rapport geeft een tussentijds overzicht van ‘state of the art’ kennis uit lopend onderzoek van het consortium ‘Climate Proof Fresh Water Supply’ (CPFWS) dat in het kader van het onderzoeksprogramma Kennis voor Klimaat wordt uitgevoerd. De focus van dit onderzoek naar een klimaatbestendige zoetwatervoorziening ligt op lokale en regionale oplossingen in Laag Nederland voor land- en tuinbouw en natuur. De zoetwatervoorziening van dit gebied wordt naast droogte vooral bedreigd door verzilting van grond- en oppervlaktewater. In zes samenhangende werkpakketten wordt geanalyseerd hoe dit gebied meer zelfvoorzienend kan worden én hoe aanpassingen in het (hoofd)watersysteem kunnen bijdragen aan de watervoorziening van het gebied. Centraal in de aanpak zijn een 3-tal casestudies in de Hotspots Haaglanden, Rotterdam Regio en Zuidwestelijke delta.
Managing climatic risks for enhanced food security: Key information capabilities
Balaghi, R. ; Badjeck, M.C. ; Bakari, D. ; Pauw, E.D. de; Wit, A.J.W. de; Defourny, P. ; Donato, S. ; Gommes, R. ; Jlibene, M. ; Ravelo, A.C. ; Sivakumar, M.V.K. ; Telahigue, N. ; Tychon, B. - \ 2010
Procedia Environmental Sciences 1 (2010). - ISSN 1878-0296 - p. 313 - 323.
prediction - agriculture - ndvi - fisheries - impacts - models
Food security is expected to face increasing challenges from climatic risks that are more and more exacerbated by climate change, especially in the developing world. This document lists some of the main capabilities that have been recently developed, especially in the area of operational agroclimatology, for an efficient use of natural resources and a better management of climatic risks. Many countries, including the developing world, now benefit from well-trained staff in the use of climate data, physical and biological information and knowledge to reduce negative climate impacts. A significant volume of data and knowledge about climate–agriculture relationships is now available and used by students, scientists, technicians, agronomists, decision-makers and farmers alike, particularly in the areas of climate characterization, land suitability and agroecological zoning, seasonal climate forecasts, drought early warning systems and operational crop forecasting systems. Climate variability has been extensively modelled, capturing important features of the climate through applied statistical procedures, agroclimatic indices derived from raw climatic data and from remote sensing. Predictions of climate at seasonal to interannual timescales are helping decision-makers in the agricultural sector to deal more effectively with the effects of climate variability. Land suitability and agroclimatic zoning have been used in many countries for agricultural planning, thanks to the availability of new and comprehensive methodologies; developments in climate, soil and remote sensing data collection and analysis; and improved applications in geographic information systems (GIS). Drought early warning systems are available worldwide at both national and international levels. These systems are helping decision-makers and farmers to take appropriate decisions to adapt to short-term climatic risks. Also, operational crop forecasting systems are now becoming available at the regional and national levels. In some developed countries, several efficient and well tested tools are now available for optimizing on-farm decisions based on the combination of crop simulation models and seasonal forecasts. However, in developing countries few tools have been developed to efficiently manage crops at the farm level to cope with climate variability and climate risks. Climate change impacts on agriculture and food security have been assessed in international studies using specific and efficient methodologies and tools. Adaptation to climate change and variability can also be facilitated through effective planning and implementation of strategies at the political level. The role of technological progress, risk transfer mechanisms and financial instruments and their easy accessibility to rural people are critical elements of climate risk management.
Mitochondrial (dys)function in adipocyte (de)-differentiation and systemic metabolic alterations
Pauw, A. de; Tejerina, S. ; Raes, M. ; Keijer, J. ; Arnould, T. - \ 2009
American Journal of Pathology 175 (2009)3. - ISSN 0002-9440 - p. 927 - 939.
white adipose-tissue - active antiretroviral therapy - polyunsaturated fatty-acids - receptor corepressor rip140 - element-binding protein - necrosis-factor-alpha - insulin-resistance - transgenic mice - uncoupling protein-3 - 3t3-l1 adipocytes
In mammals, adipose tissue, composed of BAT and WAT, collaborates in energy partitioning and performs metabolic regulatory functions. It is the most flexible tissue in the body, because it is remodeled in size and shape by modifications in adipocyte cell size and/or number, depending on developmental status and energy fluxes. Although numerous reviews have focused on the differentiation program of both brown and white adipocytes as well as on the pathophysiological role of white adipose tissues, the importance of mitochondrial activity in the differentiation or the dedifferentiation programs of adipose cells and in systemic metabolic alterations has not been extensively reviewed previously. Here, we address the crucial role of mitochondrial functions during adipogenesis and in mature adipocytes and discuss the cellular responses of white adipocytes to mitochondrial activity impairment. In addition, we discuss the increase in scientific knowledge regarding mitochondrial functions in the last 10 years and the recent suspicion of mitochondrial dysfunction in several 21st century epidemics (ie, obesity and diabetes), as well as in lipodystrophy found in HIV-treated patients, which can contribute to the development of new therapeutic strategies targeting adipocyte mitochondria
Milieu- en economiemaatregelen Evaluatie met MEBOT
Dijk, W. van; Schreuder, R. ; Pauw, J. - \ 2009
simulatiemodellen - gewasbescherming - normen - drift - pesticiden - bedrijfsinformatiesystemen - vollegrondsgroenten - beslissingsondersteunende systemen - simulation models - plant protection - standards - drift - pesticides - management information systems - field vegetables - decision support systems
Posterpresentatie. Om te voldoen aan diverse milieunormen op het gebied van gewasbescherming zijn diverse maatregelen beschikbaar. Voor een goede evaluatie van deze maatregelen moeten zowel de milieutechnische als economische effecten op gewas- en bedrijfsniveau in kaart worden gebracht. Het bedrijfsmodel MEBOT is hiervoor een geschikt instrument
Effectiviteit en kosten Good & Best Practices
Schreuder, R. ; Haan, J.J. de; Pauw, J. - \ 2008
gewasbescherming - milieueffect - modellen - evaluatie - toepassing - kosten-batenanalyse - informatieverwerking - maatregelen - vollegrondsteelt - good practices - best practices - plant protection - environmental impact - models - evaluation - application - cost benefit analysis - information processing - measures - outdoor cropping - good practices - best practices
Good & Best Practices zijn maatregelen die het milieu minder belasten en die ontwikkeld zijn in het BO-Plantgezondheidsprogramma. Toepassing van de maatregelen wordt belemmerd door ontbrekende kennis over kosten en baten ervan