Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations
Willemse, Niels ; Ark, Kees C.H. van der; Stockhofe-Zurwieden, Norbert ; Smith, Hilde ; Picavet, Daisy I. ; Solt-Smits, Conny van; Wisselink, Henk J. ; Schultsz, Constance ; Greeff, Astrid de - \ 2019
Scientific Reports 9 (2019)1. - ISSN 2045-2322

Streptococcus suis is a porcine pathogen, causing severe invasive infections. S. suis serotype 9 is increasingly causing disease in Dutch and Chinese pig herds, but it is unknown whether all serotype 9 isolates are equally virulent and markers that can identify virulent strains are not available. Therefore, discrimination between virulent isolates and carriage isolates typically not associated with disease, is currently not possible. We collected tonsillar S. suis isolates from 6 herds not previously diagnosed with S. suis infections, and clinical S. suis isolates of previously diseased pigs. We confirmed the virulence of a virulent type strain and one representative clinical isolate, and the lack of virulence of two carriage isolates, in a pig infection model. Phylogenetic analysis of whole genome sequences of 124 isolates resulted in 10 groups, of which two were almost uniquely populated by clinical isolates. The population structure of S. suis serotype 9 appears highly diverse. However, analysis of the capsule loci sequences showed variation in a single region which fully correlated with a virulent genotype. Transmission electron microscopy suggested differences in capsule thickness between carriage and clinical genotypes. In conclusion, we found that that the S. suis serotype 9 population in the Netherlands is diverse. A distinct virulence-associated lineage was identified and could be discriminated based on the capsule locus sequence. Whilst the difference in virulence cannot be directly attributed to the DNA sequence, the correlation of capsule locus sequence with virulence could be used in the development of diagnostic tests to identify potential virulent S. suis serotype 9 in pigs.

Greener living environment healthier people? Exploring green space, physical activity and health in the Doetinchem Cohort Study
Picavet, H.S.J. ; Milder, Ivon ; Kruize, Hanneke ; Vries, Sjerp de; Hermans, Tia ; Wendel-Vos, Wanda - \ 2016
Preventive Medicine 89 (2016). - ISSN 0091-7435 - p. 7 - 14.
Chronic diseases - Cohort studies - Green space - Health - Obesity - Physical activity - SF36

Background: Evidence is emerging that more green space in the living environment is associated with better health, partly via the pathway of physical activity. Objectives: We explored the cross-sectional and longitudinal associations between green space and physical activity and several health indicators in the Doetinchem Cohort Study. Methods: A random sample of men and women aged 20-59 years at baseline was measured max 5 times with 5 year-intervals in the period 1987-2012. Data of round 3-5 were used. Measurements were based on examinations (height, weight, blood pressure) or questionnaires (physical activity, perceived health, depressive symptoms, chronic conditions). The percentage of green space (mainly urban and agricultural green) around the home address (125 m and 1 km) was calculated using satellite data. Results: More agricultural green was associated with less time spent on bicycling (β1 km = - 0.15, 95%CL - 0.13; - 0.04) and sports (β1 km = - 0.04, 95%CL - 0.07; - 0.01) and more time spent on gardening (β1 km = 0.16, 95%CL 0.12; 0.19) and odd jobs (β1 km = 0.10, 95%CL 0.05; 0.15), and this was in the other direction for urban green. For only a few of the many health indicators a positive association with green was found, and mainly for total green within 1 km radius. Longstanding green or a transition to more green did not show more pronounced associations with health. Conclusions: For the green space range of the Doetinchem area the findings do not strongly support the hypothesis that the percentage of green in the living environment affects health positively. The distinction by type of green may, however, be relevant for physical activity.

Strengthening sense of coherence: opportunities for theory building in health promotion
Super, S. ; Wagemakers, M.A.E. ; Picavet, H.S.J. ; Verkooijen, K.T. ; Koelen, M.A. - \ 2016
Health Promotion International 31 (2016)4. - ISSN 0957-4824 - p. 869 - 878.
Sense of coherence (SOC) reflects a coping capacity of people to deal with everyday life stressors and consists of three elements: comprehensibility, manageability and meaningfulness. SOC is often considered to be a stable entity that is developed in young adulthood and stabilizes around the age of 30. Recent studies have questioned this stability of SOC and some studies report on interventions that have been successful in strengthening SOC in adult populations. Currently, however, there is no clear understanding of the mechanisms underlying SOC. As a consequence, it is a challenge to determine what is needed in health promotion activities to strengthen SOC. This article aims to explore the mechanisms underlying SOC as these insights may underpin future health promotion efforts. An exploration of the salutogenic model suggests two important mechanisms: the behavioural and the perceptual. The behavioural mechanism highlights the possibility to empower people to use their resources in stressful situations. The perceptual mechanism suggests that, in order for people to deal with life stressors, it is essential that they are able to reflect on their understanding of the stressful situation and the resources that are available. Based on these mechanisms, we suggest that both empowerment and reflection processes, which are interdependent, may be relevant for health promotion activities that aim to strengthen SOC. The successful application of resources to deal with stressors is not only likely to have a positive influence on health, but also creates consistent and meaningful life experiences that can positively reinforce SOC levels.
Esophageal Dysfunction in Friesian Horses: Morphological Features
Ploeg, M. ; Grone, A. ; Saey, V. ; Bruijn, C.M. de; Back, W. ; Weeren, P.R. van; Scheideman, W. ; Picavet, T. ; Ducro, B.J. ; Wijnberg, I. ; Delesalle, C. - \ 2015
Veterinary Pathology 52 (2015)6. - ISSN 0300-9858 - p. 1142 - 1147.
Megaesophagus appears to be more common in Friesian horses than in other breeds. A prevalence of approximately 2% was observed among Friesian horses presented to the Wolvega Equine Clinic and the Utrecht University Equine Clinic. In this study, morphologic changes in the esophagi of Friesian horses with megaesophagus were compared with those of 6 control horses. Of 18 horses with clinically observed megaesophagus, only 12 animals had esophageal dilation at necropsy, usually involving the thoracic portion. Muscular hypertrophy of the distal esophagus was present in only one-third of the affected horses, indicating that this change is not the most relevant cause of megaesophagus in Friesians. Increased deposition of clumped and disorganized collagen was present in these clinically affected horses mainly in the non-dilated portion of the esophagus. At necropsy, a decrease in neural elements and elastin was present principally in horses with megaesophagus. Mild degeneration and necrosis of the tunica muscularis along the entire length of the esophagus were present in clinically affected horses and encountered only rarely in control animals. There were no significant differences among affected and control horses with respect to inflammation, mineralization, or the number of cells of Cajal. The increased occurrence of megaesophagus in the Friesian breed compared with other horse breeds, together with the presence of abnormal collagen in very young foals, supports the hypothesis that megaesophagus is hereditary in Friesians
Anaerobic Digestion of Lipid-Rich Waste
Cavaleiro, A.J. ; Picavet, M.A. ; Sousa, D.Z. ; Stams, A.J.M. ; Pereira, M.A. ; Alves, M.M. - \ 2015
In: Hydrocarbon and LIpid Microbiology Protocols, Springer Protocols Handbooks / McGenity, T.J., Humana Press - ISBN 9783662531105 - p. 221 - 236.
Lipids present in waste and wastewater, also referred as fat, oil, and grease (FOG), can be efficiently converted to methane. This fact constitutes an opportunity for conserving the high energy content of waste lipids, thus facilitating its storage and future use as fuel, electricity, and heat. In anaerobic bioreactors, long-chain fatty acids (LCFAs) are released during hydrolysis of FOG. LCFAs tend to form stable emulsions, adhere to all available surfaces, and adsorb on the microbial cell walls leading to foam formation, sludge flotation, and washout, as well as temporary inhibition of microbes. These problems can be prevented if a correct balance between LCFA accumulation and biodegradation is assured, by sequential feeding and degradation steps. Appropriate reactor operation is the key strategy to prevent the excessive accumulation of LCFA and to stimulate microbial acclimation, especially during the start-up phase. After successful acclimation, a continuously feeding operation is possible, provided that there is proper process control through an adequate monitoring protocol. In addition to adequate operation, a suitable reactor design is recommended. Among other technologies, the inverted anaerobic sludge blanket (IASB) was recently developed for the direct treatment of FOG-containing wastewater. This chapter reports a protocol with a detailed operation and monitoring strategy for achieving effective methane production from FOG-containing waste and wastewater and presents a brief description of the basic concepts behind the development of the reactor
Een zwakke Sense of Coherence is geassocieerd met een hoger sterfterisico
Super, S. ; Wagemakers, M.A.E. ; Picavet, H.S.J. ; Verschuren, W.M.M. ; Zantinge, E.M. - \ 2014
In: Proceeding van Nederlands Congres Volksgezondheid 2014: Perspectieven op Volksgezondheid. - - p. 2014 - 2014.
Changes in weight and health-related quality of life. The Doetinchem Cohort Study
Milder, I.E.J. ; Hollander, E.L. de; Picavet, H.S.J. ; Verschuren, W.M.M. ; Groot, C.P.G.M. de; Bemelmans, W.J.E. - \ 2014
Journal of Epidemiology and Community Health 68 (2014). - ISSN 0143-005X - p. 471 - 477.
body-mass index - of-life - population - obesity - surgery - gender - women - sf-36
Background The cross-sectional association between obesity and a lower health-related quality of life (HRQL) is clear. However, less is known about the association between changes in weight and HRQL. We examined the association between weight changes and changes in HRQL in a population-based sample of 2005 men and 2130 women aged 26–70 years. Methods Weight was measured two or three times with 5-year intervals between 1995 and 2009, and was categorised as stable (change =2 kg, 40%), weight loss (19%), or weight gain 2.1–4.0 kg, 4.1–6.0 kg, or >6 kg (41%). Changes in HRQL (SF36 questionnaire, including physical and mental scales) per weight change category were compared with a stable weight using generalised estimating equations. Results Weight gain was associated with declines of up to 5 points on five mainly physical scales and holds for different age categories. Especially for women, a dose-response relationship was observed, that is, larger weight gain was associated with larger declines in HRQL. Changes in HRQL for those with weight loss were small, but particularly on the mental scales, changes were in the negative direction compared to a stable weight. Conclusions Weight gain and weight loss were associated with unfavourable changes in HRQL compared with a stable weight. For weight gain, this was most pronounced on the physical scales and for weight loss, although less consistent, on the mental scales.
A weak sense of coherence is associated with a higher mortality risk
Super, S. ; Verschuren, W.M.M. ; Zantinge, E.M. ; Wagemakers, M.A.E. ; Picavet, H.S.J. - \ 2014
Journal of Epidemiology and Community Health 68 (2014). - ISSN 0143-005X - p. 411 - 417.
all-cause mortality - antonovskys sense - depressive symptoms - prospective cohort - oral-health - scale - disease - time - personality - population
Background Sense of coherence (SOC) is a health-promoting resource within the salutogenic theory that reflects an individual's coping ability. The association between SOC and mental health has been confirmed, but its association with mortality is less clear. We examined the association between SOC and all-cause mortality in an adult Dutch population.
A weak sense of coherence is associated with higher mortality risk
Super, S. ; Verschuren, W.M.M. ; Zantinge, E. ; Wagemakers, A. ; Picavet, H.S.J. - \ 2013
The Impact of Long-Term Body Mass Index Patterns on Health-Related Quality: The Doetinchem Cohort Study
Hollander, E.L. de; Picavet, H.S.J. ; Milder, I.E.J. ; Verschuren, W.M.M. ; Bemelmans, W.J.E. ; Groot, C.P.G.M. de - \ 2013
American Journal of Epidemiology 178 (2013)5. - ISSN 0002-9262 - p. 804 - 812.
weight change - physical-activity - whitehall ii - obesity - population - mortality - adults - us - women - predictors
Overweight is associated with a reduced health-related quality of life (QOL), but less is known about the impact of long-term body mass index (BMI, calculated as weight (kg)/height (m)2) patterns on QOL in adults. In the Dutch Doetinchem Cohort Study (1989–2009) that included 1,677 men and 1,731 women aged 20–66 years, 6 BMI patterns were defined by using 4 measurements over a 15-year period: 1) persistent healthy weight (18.5–24.9, reference pattern); 2) persistent overweight (25.0–29.9); 3) persistent obesity (=30.0); 4) developing overweight; 5) developing obesity; and 6) switching between BMI categories. For each BMI pattern, adjusted QOL (measured on a 0–100 scale) was estimated at the end of this period. The lowest QOL was observed for persistent obesity of all BMI patterns. It was 5.0 points (P = 0.02) lower for 1 mental dimension in men and 6.2–11.6 points (P <0.05) lower for 5 (mainly physical) dimensions in women. Developing overweight or obesity scored 1.8–6.3 points (P <0.05) lower on 2–5 (mainly physical) dimensions. Persistent overweight hardly differed from a persistent healthy weight. In women, switching between BMI categories resulted in a lower QOL on the mental dimensions. Studying long-term BMI patterns over a 15-year period showed that persistent obesity, developing overweight, and developing obesity resulted in a lower QOL—particularly on the physical dimensions—compared with a persistent healthy weight.
The impact of long-term BMI patterns on quality of life. The Doetinchem Cohort Study
Hollander, E.L. de; Picavet, H.S.J. ; Milder, I.E.J. ; Verschuren, W.M.M. ; Bemelmans, W.J.E. ; Groot, C.P.G.M. de - \ 2012
Are changes in weight associated with changes in health-related quality of life? The Doetinchem Cohort Study
Milder, I.E.J. ; Hollander, E.L. de; Picavet, H.S.J. ; Verschuren, W.M.M. ; Groot, C.P.G.M. de; Bemelmans, W.J.E. - \ 2012
The relation between changes in weight and health-related quality of life in the Doetinchem Cohort Study
Milder, I.E.J. ; Hollander, E.L. de; Picavet, H.S.J. ; Verschuren, W.M.M. ; Groot, C.P.G.M. de; Bemelmans, W.J.E. - \ 2012
Longitudinal associations between physical load and chronic low back pain in the general population: the Doetichem Cohort Study
Oostrom, S.H. ; Verschuren, M. ; Vet, H.C. de; Boshuizen, H.C. ; Picavet, H.S. - \ 2012
Spine 37 (2012)9. - ISSN 0362-2436 - p. 788 - 796.
life-course epidemiology - risk-factors - work - exposures
Study Design. Prospective cohort study. Objective. We explored long-term associations between physical load exposure and chronic low back pain (LBP) using data from an ongoing population-based cohort study. Summary of Background Data. Physical load in work or daily life is often studied in relation to LBP. Most studies are cross-sectional or have a limited follow-up. Methods. Between 1993 and 2007, 4738 men and women aged 25 to 64 years were measured maximal 3 times with 5-year intervals. Physical load in daily activities (9 items, e. g., awkward postures, mechanical vibration) was assessed by questionnaire at 2 measurements and chronic LBP 3 times. Physical load exposure at both measurements was described. Multivariable logistic regression analyses were adjusted for sex, age, education, work status, body mass index, physical activity, and smoking. Results. Despite stable prevalence rates of physical load exposure, about 50% of the participants exposed changed their exposure during a 5-year period. 7.2% of the participants reported awkward postures at 2 measurements, 8.4% at the first measurement only, and 6.8% at the second measurement only. Among all physical load variables, associations with chronic LBP were found only for awkward postures. An increased risk for incident chronic LBP was found in participants exposed twice to awkward postures. In contrast, only single exposure to awkward postures was associated with persistence of chronic LBP. Conclusion. Awkward postures were associated with chronic LBP in the general population. Exposure to awkward postures at 2 measurements with 5 years in between did increase the risk for incident chronic LBP, but not for persistence of chronic LBP.
Weight change and change in health-related quality of life in the Doetinchem Cohort Study
Milder, I.E.J. ; Hollander, E.L. de; Picavet, H.S.J. ; Verschuren, W.M.M. ; Groot, C.P.G.M. de; Bemelmans, W.J.E. - \ 2012
Do positive or negative experiences of social support relate to current and future health? Results from the Doetinchem Cohort Study
Croezen, S. ; Picavet, H.S.J. ; Haveman-Nies, A. ; Verschuren, W.M.M. ; Groot, C.P.G.M. de; Veer, P. van 't - \ 2012
BMC Public Health 12 (2012). - ISSN 1471-2458 - 8 p.
mental-health - depressive symptoms - general-population - physical-activity - older-adults - validity - disease - mortality - network - reproducibility
Background Cross-sectional studies have reported associations between social support and health, but prospective evidence is less conclusive. This study aims to investigate the associations of positive and negative experiences of social support with current and future lifestyle factors, biological risk factors, self-perceived health and mental health over a 10-year period. Methods Data were from 4,724 Dutch men and women aged 26-65 years who participated in the second (1993-1997) and in the third (1998-2002) or fourth (2003-2007) study round of the Doetinchem Cohort Study. Social support was measured at round two using the Social Experiences Checklist. Health was assessed by several indicators such as smoking, alcohol consumption, physical activity, fruit and vegetable intake, overweight, hypertension, hypercholesterolemia, self-perceived health and mental health. Tertiles of positive and negative experiences of social support were analysed in association with repeated measurements of prevalence and incidence of several health indicators using generalised estimating equations (GEE). Results Positive and negative experiences of social support were associated with prevalence and incidence of poor mental health. For the lowest tertile of positive support, odds ratios were 2.74 (95% CI 2.32-3.23) for prevalent poor mental health and 1.86 (95% CI 1.39-2.49) for incident poor mental health. For the highest tertile of negatively experienced support, odds ratios for prevalent and incident poor mental health were 3.28 (95% CI 2.78-3.87) and 1.60 (95% CI 1.21-2.12), respectively. Low levels of positive experiences of social support were also associated with low current intake of fruits and vegetables, but not with future intake. Negative experiences of social support were additionally associated with current smoking, physical inactivity, overweight and poor self-perceived health. Furthermore, high levels of negative experiences of social support were associated with future excessive alcohol consumption (OR 1.42; 95% CI 1.10-1.84), physical inactivity (95% CI 1.28; 1.03-1.58) and poor self-perceived health (OR 1.36; 95% CI 1.01-1.82).
The influence of social support on health and mortality
Haveman-Nies, A. ; Picavet, H.S.J. ; Croezen, S. ; Verschuren, M.M. ; Groot, C.P.G.M. de; Veer, P. van 't - \ 2011
- p. 1 - 50.
The influences of social support on health and mortality
Croezen, S. ; Picavet, H.S.J. ; Haveman-Nies, A. ; Groot, C.P.G.M. de; Verschuren, M.M. ; Veer, P. van 't - \ 2011
The influences of social support on health and mortality
Croezen, S. ; Picavet, S. ; Haveman-Nies, A. ; Verschuren, M. ; Groot, C.P.G.M. de; Veer, P. van 't - \ 2011
Weight change and incident diabetes: addressing an unresolved issue
Jacobs-van der Bruggen, M.A.M. ; Spijkerman, A.M.W. ; Baal, P.H.M. van; Baan, C.A. ; Feskens, E.J.M. ; Picavet, H.S.J. ; A, A.D. van der; Verschuren, W.M.M. - \ 2010
American Journal of Epidemiology 172 (2010)3. - ISSN 0002-9262 - p. 263 - 270.
body-mass index - impaired glucose-tolerance - life-style intervention - overweight adults - fat distribution - womens-health - risk-factors - type-2 - obesity - mellitus
The impact of weight change on diabetes incidence remains unclear. To clarify the role of weight change as a risk factor for diabetes, the authors assessed the association between weight change and diabetes incidence conditional upon either initial or attained body mass index (BMI). They used 7,837 observations available from repeated measurements of 4,259 participants (men and women aged 20–59 years) in the Dutch population-based Doetinchem Cohort Study (1987–2007) to analyze the association between 5-year weight change and diabetes incidence (n = 124) in the subsequent 5 years. When adjusted for initial BMI, 5-year weight change was a significant risk factor for diabetes (odds ratio = 1.08, 95% confidence interval: 1.04, 1.13 per kilogram of weight change). However, no significant association was found between weight change and diabetes if the association was adjusted for attained BMI (odds ratio = 0.99, 95% confidence interval: 0.94, 1.04 per kilogram of weight change). Results suggest that weight change is associated with diabetes incidence because, conditional upon initial BMI, weight change determines attained BMI. This finding implies that lifestyle interventions can contribute to diabetes prevention because they affect attained BMI. Weight change appears to have no effect on diabetes incidence beyond its effect on attained BMI.
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