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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

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A Novel Approach to Improve the Estimation of a Diet Adherence Considering Seasonality and Short Term Variability – The NU-AGE Mediterranean Diet Experience
Giampieri, Enrico ; Ostan, Rita ; Guidarelli, Giulia ; Salvioli, Stefano ; Berendsen, A.M. ; Brzozowska, Anna ; Pietruszka, Barbara ; Jennings, Amy ; Meunier, Nathalie ; Caumon, Elodie ; Fairweather-Tait, Susan J. ; Sicinska, Ewa ; Feskens, E.J.M. ; Groot, C.P.G.M. de; Franceschi, Claudio ; Santoro, Aurelia - \ 2019
Frontiers in Physiology 10 (2019). - ISSN 1664-042X
In this work we present a novel statistical approach to improve the assessment of the adherence to a 1-year nutritional intervention within the framework of the NU-AGE project. This was measured with a single adherence score based on 7-days food records, under limitations on the number of observations per subject and time frame of intervention. The results of the NU-AGE dietary intervention were summarized by variations of the NU-AGE index as described in the NU-AGE protocol. Food and nutrient intake of all participants was assessed by means of 7-days food records at recruitment and after 10 to 14 months of intervention (depending on the subject availability). Sixteen food groups and supplementations covering the dietary goals of the NU-AGE diet have been used to estimate the NU-AGE index before and after the intervention. The 7-days food record is a reliable tool to register food intakes, however, as with other tools used to assess lifestyle dietary compliance, it is affected by uncertainty in this estimation due to the possibility that the observed week is not fully representative of the entire intervention period. Also, due to logistic limitations, the effects of seasonality can never be completely removed. These variabilities, if not accounted for in the index estimation, will reduce the statistical power of the analyses. In this work we discuss a method to assess these uncertainties and thus improve the resulting NU-AGE index. The proposed method is based on Hierarchical Bayesian Models. This model explicitly includes country-specific averages of the NU-AGE index, index variation induced by the dietary intervention, and country based seasonality. This information is used to evaluate the NU-AGE index uncertainty and thus to estimate the “real” NU-AGE index for each subject, both before and after the intervention. These corrections reduce the possibility of misinterpreting measurement variability as real information, improving the power of the statistical tests that are performed with the resulting index. The results suggest that this method is able to reduce the short term and seasonal variability of the measured index in the context of multicenter dietary intervention trials. Using this method to estimate seasonality and variability would allow one to obtain better measurements from the subjects of a study, and be able to simplify the scheduling of diet assessments.
Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults
Jennings, A. ; Berendsen, A.M. ; Groot, C.P.G.M. de; Feskens, E.J.M. ; Brzozowska, A. ; Sicinska, Ewa ; Pietruszka, Barbara ; Meunier, N. ; Caumon, Elodie ; Malpuech-Brugère, Corinne ; Santoro, Aurelia ; Ostan, Rita ; Franceschi, Claudio ; Gillings, Rachel ; O'Neill, C.M. ; Fairweather-Tait, Susan J. ; Minihane, Anne-Marie ; Cassidy, Aedin - \ 2019
Hypertension 73 (2019)3. - ISSN 0194-911X - p. 578 - 586.
We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. The control group continued on their habitual diet and was provided with current national dietary guidance. In the 1142 participants who completed the trial (88.2%), after 1 year the intervention resulted in a significant reduction in systolic blood pressure (−5.5 mm Hg; 95% CI, −10.7 to −0.4; P=0.03), which was evident in males (−9.2 mm Hg, P=0.02) but not females (−3.1 mm Hg, P=0.37). The −1.7 mm Hg (95% CI, −4.3 to 0.9) decrease in diastolic pressure after intervention did not reach statistical significance. In a subset (n=225), augmentation index, a measure of arterial stiffness, was improved following intervention (−12.4; 95% CI, −24.4 to −0.5; P=0.04) with no change in pulse wave velocity. The intervention also resulted in an increase in 24-hour urinary potassium (8.8 mmol/L; 95% CI, 0.7–16.9; P=0.03) and in male participants (52%) a reduction in pulse pressure (−6.1 mm Hg; 95% CI, −12.0 to −0.2; P=0.04) and 24-hour urinary sodium (−27.1 mmol/L; 95% CI, −53.3 to −1.0; P=0.04). In conclusion, a Mediterranean-style diet is effective in improving cardiovascular health with clinically relevant reductions in blood pressure and arterial stiffness.
Changes in Dietary Intake and Adherence to the NU-AGE Diet Following a One-Year Dietary Intervention among European Older Adults-Results of the NU-AGE Randomized Trial
Berendsen, A.M. ; Rest, O. van de; Feskens, E.J.M. ; Santoro, Aurelia ; Ostan, R. ; Pietruszka, Barbara ; Brzozowska, A. ; Stelmaszczyk-Kusz, A. ; Jennings, A. ; Gillings, Rachel ; Cassidy, A. ; Caille, A. ; Caumon, Elodie ; Malpuech-Brugère, Corinne ; Franceschi, Claudio ; Groot, C.P.G.M. de - \ 2018
Nutrients 10 (2018). - ISSN 2072-6643
Background: The Mediterranean Diet has been proposed as an effective strategy to reduce inflammaging, a chronic low grade inflammatory status, and thus, to slow down the aging process. We evaluated whether a Mediterranean-like dietary pattern specifically targeting dietary recommendations of people aged over 65 years (NU-AGE diet) could be effective to shift dietary intake of older adults towards a healthful diet. Methods: Adults aged 65–80 years across five EU-centers were randomly assigned to a NU-AGE diet group or control group. The diet group followed one year of NU-AGE dietary intervention specifying consumption of 15 food groups plus the use of a vitamin D supplement. Participants in the diet group received counselling and individually tailored dietary advice, food products and a vitamin D supplement. Dietary intake was assessed by means of seven-day food records at baseline and one-year follow-up. A continuous NU-AGE index (0–160 points) was developed to assess NU-AGE diet adherence. Results: In total 1296 participants were randomized and 1141 participants completed the intervention (571 intervention, 570 control). After one year, the diet group improved mean intake of 13 out of 16 NU-AGE dietary components (p < 0.05), with a significant increase in total NU-AGE index (difference in mean change = 21.3 ± 15.9 points, p < 0.01). Conclusions: The NU-AGE dietary intervention, based on dietary recommendations for older adults, consisting of individual dietary counselling, free healthy foods and a vitamin D supplement, may be a feasible strategy to improve dietary intake in an aging European population.
A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features
Santoro, Aurelia ; Bazzocchi, Alberto ; Guidarelli, Giulia ; Ostan, Rita ; Giampieri, Enrico ; Mercatelli, Daniele ; Scurti, M. ; Berendsen, A.M. ; Surala, Olga ; Jennings, Amy ; Meunier, Nathalie ; Caumon, Elodie ; Gillings, Rachel ; Kadi, Fawzi ; Capel, Frederic ; Cashman, Kevin D. ; Pietruszka, Barbara ; Feskens, E.J.M. ; Groot, C.P.G.M. de; Battista, Giuseppe ; Salvioli, Stefano ; Franceschi, Claudio - \ 2018
Frontiers in Physiology 9 (2018). - ISSN 1664-042X - 16 p.
Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65–79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67%, p < 2.2e-16) and lower lean mass (Lean Mass index: by -18%, p < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56%, p < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52%, p < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23%, p < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34%, p < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18%, p < 2.2e-16). Moreover, five BC profiles in women and six in men have been identified by a cluster analysis based on BC parameters. Finally, these data can serve as reference for normative average and variability of BC in the elderly populations across Europe.
A Mediterranean-like dietary pattern with Vitamin D3 (10 μg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline : Results of a 1-y randomized controlled trial
Jennings, Amy ; Cashman, Kevin D. ; Gillings, Rachel ; Cassidy, Aedin ; Tang, Jonathan ; Fraser, William ; Dowling, Kirsten G. ; Hull, George L.J. ; Berendsen, Agnes A.M. ; Groot, Lisette C.P.G.M. de; Pietruszka, Barbara ; Wierzbicka, Elzbieta ; Ostan, Rita ; Bazzocchi, Alberto ; Battista, Giuseppe ; Caumon, Elodie ; Meunier, Nathalie ; Malpuech-Brugère, Corinne ; Franceschi, Claudio ; Santoro, Aurelia ; Fairweather-Tait, Susan J. - \ 2018
American Journal of Clinical Nutrition 108 (2018)3. - ISSN 0002-9165 - p. 633 - 640.
bone - Mediterranean diet - older adults - Osteoporosis - Vitamin D supplementation

Background: The Mediterranean diet (MD) is widely recommended for the prevention of chronic disease, but evidence for a beneficial effect on bone health is lacking. Objective: The aim of this study was to examine the effect of a Mediterranean-like dietary pattern [NU-AGE (New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe)] on indexes of inflammation with a number of secondary endpoints, including bone mineral density (BMD) and biomarkers of bone and collagen degradation in a 1-y multicenter randomized controlled trial (RCT; NU-AGE) in elderly Europeans. Design: An RCT was undertaken across 5 European centers. Subjects in the intervention group consumed the NU-AGE diet for 1 y by receiving individually tailored dietary advice, coupled with supplies of foods including whole-grain pasta, olive oil, and a vitamin D3 supplement (10 μg/d). Participants in the control group were provided with leaflets on healthy eating available in their country. Results: A total of 1294 participants (mean ± SD age: 70.9 ±4.0 y; 44% male) were recruited to the study and 1142 completed the 1-y trial. The Mediterranean-like dietary pattern had no effect on BMD (site-specific or whole-body); the inclusion of compliance to the intervention in the statistical model did not change the findings. There was also no effect of the intervention on the urinary biomarkers free pyridinoline or free deoxypyridinoline. Serum 25-hydroxyvitamin D significantly increased and parathyroid hormone decreased (P < 0.001) in the MD compared with the control group. Subgroup analysis of individuals with osteoporosis at baseline (site-specific BMD T-score ≤ -2.5 SDs) showed that the MD attenuated the expected decline in femoral neck BMD (n = 24 and 30 in MD and control groups, respectively; P = 0.04) but had no effect on lumbar spine or whole-body BMD. Conclusions: A 1-y intervention of the Mediterranean-like diet together with vitamin D3 supplements (10 μg/d) had no effect on BMD in the normal age-related range, but it significantly reduced the rate of loss of bone at the femoral neck in individuals with osteoporosis. The NU-AGE trial is registered at clinicaltrials.gov as NCT01754012.

Cross-Sectional Analysis of the Correlation Between Daily Nutrient Intake Assessed by 7-Day Food Records and Biomarkers of Dietary Intake Among Participants of the NU-AGE Study
Ostan, Rita ; Guidarelli, Giulia ; Giampieri, Enrico ; Lanzarini, Catia ; Berendsen, Agnes A.M. ; Januszko, Olga ; Jennings, Amy ; Lyon, Noëlle ; Caumon, Elodie ; Gillings, Rachel ; Sicinska, Ewa ; Meunier, Nathalie ; Feskens, Edith J.M. ; Pietruszka, Barbara ; Groot, Lisette C.P.G.M. de; Fairweather-Tait, Susan ; Capri, Miriam ; Franceschi, Claudio ; Santoro, Aurelia - \ 2018
Frontiers in Physiology 9 (2018). - ISSN 1664-042X
Methods for measuring diet composition and quantifying nutrient intake with sufficient validity are essential to study the association between nutrition and health outcomes and risk of diseases. 7-day food records provides a quantification of food actually and currently consumed and is interesting for its use in intervention studies to monitor diet in a short-term period and to guide participants toward changing their intakes. The objective of this study is to analyze the correlation/association between the daily intake of selected nutrients (collected by a 7-day food records plus a mineral/vitamin supplementation questionnaire) and estimates of energy expenditure as well as blood and urine biomarkers of dietary intakes in 1,140 healthy elderly subjects (65–79 years) at baseline of the NU-AGE intervention study (NCT01754012, clinicaltrials.gov). The results show that: the daily intake of energy correlated significantly with predicted total energy expenditure (pTEE) (ρ = 0.459, p < 0.001, and q < 0.001); protein intake correlated significantly with the ratio of 24 h urinary urea to creatinine excretion (ρ = 0.143 for total protein intake, ρ = 0.296 for animal protein intake, and ρ = 0.359 for protein intake/body weight, p < 0.001 and q < 0.001 for each correlation); vitamin B12 and folate intakes correlated significantly with their serum concentrations (ρ = 0.151 and ρ = 0.363, respectively; p < 0.001 and q < 0.001 for each correlation); sodium and potassium intakes correlated significantly with their 24 h urinary excretion (ρ = 0.298 and ρ = 0.123, respectively; p < 0.001 and q < 0.001 for each correlation); vitamin B12 and folate intakes were negatively associated with plasma homocysteine measure (p = 0.001 and p = 0.004, respectively); stratifying subjects by gender, the correlations between energy intake and pTEE and between potassium intake and its 24 h urinary excretion lost their significance in women. Even if the plasma and urinary levels of these nutrients depend on several factors, the significant correlations between daily reported intake of nutrients (protein, vitamin B12, folate, and sodium) and their blood/urinary markers confirmed that the 7-day food records (plus a supplementation questionnaire) provides reliable data to evaluate short-term current dietary intake in European elderly subjects and it can be exploited to guide and monitor NU-AGE participants through the shift of their diet according NU-AGE recommendations.
Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults
Montiel Rojas, Diego ; Nilsson, Andreas ; Ponsot, Elodie ; Brummer, Robert J. ; Fairweather-Tait, Susan ; Jennings, Amy ; Groot, Lisette C.P.G.M. De; Berendsen, Agnes ; Pietruszka, Barbara ; Madej, Dawid ; Caumon, Elodie ; Meunier, Nathalie ; Malpuech-Brugère, Corinne ; Guidarelli, Giulia ; Santoro, Aurelia ; Franceschi, Claudio ; Kadi, Fawzi - \ 2018
Frontiers in Physiology 9 (2018). - ISSN 1664-042X
The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. A total of 1,221 adults (65–79 years) were recruited from five European countries within the framework of NU-AGE study. The physical functioning construct was based on the 36-item Short Form Health Survey. Handgrip strength was used as a single indicator of muscle function and LTL was assessed using quantitative real-time PCR. Women had significantly longer (p < 0.05) LTL than men. Participants in Poland had significantly shorter LTL than in the other study centers, whereas participants in the Netherlands had significantly longer LTL than most of the other centers (p < 0.01). An analysis of LTL as a continuous outcome against physical functioning by using linear models revealed inconsistent findings. In contrast, based on an analysis of contrasting telomere lengths (first vs. fifth quintile of LTL), a significant odds ratio (OR) of 1.7 (95% CI: 1.1 – 2.6; p < 0.05) of having functional limitation was observed in those belonging to the first LTL quintile compared to the fifth. Interestingly, having the shortest LTL was still related to a higher likelihood of having physical limitation when compared to all remaining quintiles (OR: 1.5, 95% CI: 1.1 – 2.1; p < 0.05), even after adjustment by study center, age, sex, and overweight status. Collectively, our findings suggest that short LTL is an independent risk factor that accounts for functional decline in elderly European populations. The influence of LTL on functional limitation seems driven by the detrimental effect of having short telomeres rather than reflecting a linear dose-response relationship.
Are Nutrition-Related Knowledge and Attitudes Reflected in Lifestyle and Health Among Elderly People? A Study Across Five European Countries
Jeruszka-Bielak, Marta ; Kollajtis-Dolowy, Anna ; Santoro, A. ; Ostan, R. ; Berendsen, A.M. ; Jennings, A. ; Meunier, N. ; Marseglia, Anna ; Caumon, E. ; Gillings, Rachel ; Groot, C.P.G.M. de; Franceschi, Claudio ; Hieke, Sophie ; Pietruszka, B. - \ 2018
Frontiers in Physiology 9 (2018). - ISSN 1664-042X - 13 p.
Background: Nutrition-related knowledge (NRK) and nutrition-related attitudes (NRAs) are necessary for dietary changes toward healthier dietary patterns. In turn, healthier dietary patterns can be beneficial in maintaining health of older adults. Therefore, the aim of this cross-sectional study was to investigate whether NRK and NRAs were associated with lifestyle and health features among older adults (65+ years) from five European countries (France, Italy, Poland, the Netherlands and United Kingdom). Methods: Within the European project NU-AGE, 1,144 healthy elderly volunteers (65–79 years) were randomly assigned to two groups: intervention (NU-AGE diet) or control. After 1-year of follow-up, both NRK and NRAs were assessed during exit interviews, in combination with a number of lifestyle and health variables (e.g., physical activity, smoking, alcohol use, BMI, self-assessed health status). Multivariable linear regression models were used in data analysis. Results: In the NU-AGE study sample, good NRK was associated with lower BMI and higher physical activity. More positive NRAs were related to lower BMI and self-reported very good or good appetite. Moreover, both NRK and NRAs were associated with some socio-economic determinants, like financial situation, age, education, living area (for NRK), and country (for NRAs). Participants in the intervention group showed a better NRK (β = 0.367 [95% CI: 0.117; 0.617], p = 0.004) and more positive NRAs (β = 0.838 [95% CI: 0.318; 1.358], p = 0.002) than those in the control group. Higher self-evaluated knowledge was also significantly related to more positive NRAs (p < 0.001). The most popular sources of nutrition information were food labels, books and magazines on health, the dietitian and the doctor's office, although their importance varied significantly among countries, and, to a lesser extent, between women and men and between intervention and control group. Conclusion: Higher NRK and NRA scores were associated with lower BMI and higher physical activity level. Therefore, a good nutrition-related knowledge and positive nutrition-related attitudes can strongly and positively influence the health status and quality of life among the older population. These results offer a great opportunity for policy makers to implement educational programs in order to counteract the epidemic of obesity and to improve the health span of European population.
Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults : A Randomized Controlled Trial
Marseglia, Anna ; Xu, W. ; Fratiglioni, Laura ; Fabbri, Cristina ; Berendsen, A.M. ; Bialecka-Debek, Agata ; Jennings, A. ; Gillings, Rachel ; Meunier, N. ; Caumon, E. ; Fairweather-Tait, S. ; Pietruszka, B. ; Groot, C.P.G.M. de; Santoro, A. ; Franceschi, Claudio - \ 2018
Frontiers in Physiology 9 (2018). - ISSN 1664-042X
Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet-neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE’s dietary intervention on age-related cognitive decline.
Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65–79 years, from five European centers. Participants were randomly allocated into two groups: “control” (n = 638), following a habitual diet; and, “intervention” (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD-total score), and five cognitive domains (perceptual speed, executive function, episodic
memory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed-effects models.
Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) from
the intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. However, participants with higher adherence to the NU-AGE diet showed statistically significant improvements in global cognition [b 0.20 (95%CI 0.004, 0.39), p-value = 0.046] and episodic memory [b 0.15 (95%CI 0.02, 0.28), p-value = 0.025] after 1 year, compared to those adults with lower adherence.
Discussion: High adherence to the culturally adapted, individually tailored, NU-AGE diet could slow down age-related cognitive decline, helping to prevent cognitive impairment and dementia.
Effect Of The NU-AGE Individually Tailored Diet On Cognitive Function: A Randomized Control Trial
Marseglia, Anna ; Xu, Weili ; Santoro, A. ; Scurti, M. ; Berendsen, A.M. ; Pietruszka, B. ; Jennings, A. ; Meunier, N. ; Caumon, E. ; Fairweather-Tait, S. ; Brzozowska, A. ; Groot, C.P.G.M. de; Franceschi, C. - \ 2017
Nouvelles strategies alimentaires pour un vieillissement optimisé des seniors européens – Projet européen FP7 NU-AGE
Meunier, N. ; Caumon, E. ; Lyon, N. ; Caille, A. ; Berendsen, A.M. ; Groot, C.P.G.M. de; Feskens, E.J.M. ; Santoro, A. ; Franceschi, C. ; Pietruszka, B. ; Brzozowska, A.M. ; Jennings, A. ; Fairweather-Tait, S. ; Cano, N. - \ 2014
Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study
Berendsen, A.M. ; Santoro, A. ; Pini, E. ; Cevenini, E. ; Ostan, R. ; Pietruszka, B. ; Rolf, K. ; Cano, N. ; Caille, A. ; Lyon-Belgy, N. ; Fairweather-Tait, S. ; Feskens, E.J.M. ; Franceschi, C. ; Groot, C.P.G.M. de - \ 2014
Mechanisms of Ageing and Development 136-137 (2014). - ISSN 0047-6374 - p. 14 - 21.
cardiovascular risk-factors - mediterranean diet - vitamin-d - metabolic syndrome - older-adults - nutritional-status - blood-pressure - fatty-acids - weight-loss - life-style
Background The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly. Methods The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65–80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome. Discussion The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study
Berendsen, A.M. ; Santoro, A. ; Pini, E. ; Cevenini, E. ; Ostan, R. ; Pietruszka, B. ; Rolf, K. ; Cano, R. ; Caille, A. ; Lyon-Belgy, N. ; Fairweather-Tait, S. ; Feskens, E.J.M. ; Franceschi, C. ; Groot, C.P.G.M. de - \ 2013
Mechanisms of Ageing and Development 134 (2013)11-12. - ISSN 0047-6374 - p. 523 - 530.
cardiovascular risk-factors - mediterranean diet - vitamin-d - metabolic syndrome - older-adults - nutritional-status - blood-pressure - fatty-acids - weight-loss - life-style
Background The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly. Methods The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65–80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome. Discussion The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
A randomized trial on the effect of a full dietary intervention on ageing in European elderly people: the Nu-Age study
Berendsen, A.M. ; Santoro, A. ; Pini, E. ; Cevenini, E. ; Ostan, R. ; Pietruszka, B. ; Rolf, K. ; Cano, N. ; Caille, A. ; Lyon-Belgy, N. ; Fairweather-Tait, S. ; Feskens, E.J.M. ; Franceschi, C. ; Groot, C.P.G.M. de - \ 2013
Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses
Wijngaarden, J.P. van; Doets, E.L. ; Szczecinkska, A. ; Souverein, O.W. ; Duffy, M.E. ; Dullemeijer, C. ; Cavelaars, A.J.E.M. ; Pietruszka, B. ; Veer, P. van 't; Brzozowska, A.M. ; Dhonukshe-Rutten, R.A.M. ; Groot, C.P.G.M. de - \ 2013
Journal of Nutrition and Metabolism 2013 (2013). - ISSN 2090-0724 - 19 p.
Elevated homocysteine levels and low vitamin B12 and folate levels have been associated with deteriorated bone health. This systematic literature review with dose-response meta-analyses summarizes the available scientific evidence on associations of vitamin B12, folate, and homocysteine status with fractures and bone mineral density (BMD). Twenty-seven eligible cross-sectional () and prospective () observational studies and one RCT were identified. Meta-analysis on four prospective studies including 7475 people showed a modest decrease in fracture risk of 4% per 50¿pmol/L increase in vitamin B12 levels, which was borderline significant (RR = 0.96, 95% CI = 0.92 to 1.00). Meta-analysis of eight studies including 11511 people showed an increased fracture risk of 4% per µmol/L increase in homocysteine concentration (RR = 1.04, 95% CI = 1.02 to 1.07). We could not draw a conclusion regarding folate levels and fracture risk, as too few studies investigated this association. Meta-analyses regarding vitamin B12, folate and homocysteine levels, and BMD were possible in female populations only and showed no associations. Results from studies regarding BMD that could not be included in the meta-analyses were not univocal.
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