Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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A whole genome scan for Quantitative Trait Loci (QTL) affecting teat number in pigs
Hirooka, H. ; Koning, D.J. de; Harlizius, B. ; Arendonk, J.A.M. van; Rattink, A.P. ; Groenen, M.A.M. ; Brascamp, E.W. ; Bovenhuis, H. - \ 2001
Journal of Animal Science 79 (2001). - ISSN 0021-8812 - p. 2320 - 2326.
A whole-genome scan was conducted using 132 microsatellite markers to identify chromosomal regions that have an effect on teat number. For this purpose, an experimental cross between Chinese Meishan pigs and five commercial Dutch pig lines was used. Linkage analyses were performed using interval mapping by regression under line cross models including a test for imprinting effects. The whole-genome scan revealed highly significant evidence for three quantitative trait loci (QTL) affecting teat number, of which two were imprinted. Paternally expressed (i.e., maternally imprinted) QTL were found on chromosomes 2 and 12. A Mendelian expressed QTL was found on chromosome 10. The estimated additive effects showed that, for the QTL on chromosomes 10 and 12, the Meishan allele had a positive effect on teat number, but, for the QTL on chromosome 2, the Meishan allele had a negative effect on teat number. This study shows that imprinting may play an important role in the expression of teat number.
Detection and characterization of quantitative trait loci for growth and reproduction traits in pigs
Koning, D.J. de; Rattink, A.P. ; Harlizius, B. ; Groenen, M.A.M. ; Brascamp, E.W. ; Arendonk, J.A.M. van - \ 2001
Livestock Production Science 72 (2001). - ISSN 0301-6226 - p. 185 - 198.
Detection and characterization of quantitative trait loci for meat quality traits in pigs
Koning, D.J. de; Harlizius, B. ; Rattink, A.P. ; Groenen, M.A.M. ; Brascamp, E.W. ; Arendonk, J.A.M. van - \ 2001
Journal of Animal Science 79 (2001). - ISSN 0021-8812 - p. 2812 - 2819.
In an experimental cross between Meishan and Dutch Large White and Landrace lines, 785 F2 animals with carcass information and their parents were typed for molecular markers covering the entire porcine genome. Linkage was studied between these markers and eight meat quality traits. Quantitative trait locus analyses were performed using interval mapping by regression under two genetic models: 1) the line-cross approach, where the founder lines were assumed to be fixed for different QTL alleles and 2) a half-sib model where a unique allele substitution effect was fitted within each of the 38 half-sib families. The line-cross approach included tests for genomic imprinting and sex-specific QTL effects. In total, three genome-wide significant and 26 suggestive QTL were detected. The significant QTL on chromosomes 3, 4, and 13, affecting meat color, were only detected under the half-sib model. Failure of the line-cross approach to detect the meat color QTL suggests that the founder lines have similar allele frequencies for these QTL. This study provides information on new QTL affecting meat quality traits. It also shows the benefit of analyzing experimental data under different genetic and statistical models.
A high-resolution comparative RH map of porcine chromosome (SSC) 2.
Rattink, A.P. ; Faivre, M. ; Jungerius, B.J. ; Groenen, M.A.M. ; Harlizius, B. - \ 2001
Mammalian Genome 12 (2001)5. - ISSN 0938-8990 - p. 366 - 370.
A high-resolution comparative map was constructed for porcine Chromosome (SSC) 2, where a QTL for back fat thickness (BFT) is located. A radiation hybrid (RH) map containing 33 genes and 25 microsatellite markers was constructed for this chromosome with a 3000-rad porcine RH panel. In total, 16 genes from human Chromosome (HSA) 11p, HSA19p, and HSA5q were newly assigned to SSC2. One linkage group was observed at LOD 3.0, and five linkage groups at LOD 4.0. Comparison of the porcine RH map with homologous human gene orders identified four conserved segments between SSC2 and HSA11, HSA19, and HSA5. Concerning HSA11, a rearrangement of gene order is observed. The segment HSA11p15.4-q13 is inverted on SSC2 when compared with the distal tip of SSC2p, which is homologous to HSA11p15.5. The boundaries of the conserved segments between human and pig were defined more precisely. This high-resolution comparative map will be a valuable tool for further fine mapping of the QTL area.
Fine mapping and imprinting analysis for fatness trait QTL's in pigs
Rattink, A.P. ; Koning, D.J. de; Faivre, M. ; Harlizius, B. ; Arendonk, J.A.M. van; Groenen, M.A.M. - \ 2000
Mammalian Genome 11 (2000). - ISSN 0938-8990 - p. 656 - 661.
Comparative mapping of a region on pig chromosome 2 containing a QTL for backfat thickness
Rattink, A.P. ; Harlizius, B. ; Chardon, P. ; Faivre, M. ; Groenen, M.A.M. - \ 2000
In: Book of Abstracts : NWO retraite genetica, Rolduc - p. 7 - 7.
Comparison mapping of a region on pig chromosome 2 containing a QTL for backfat thickness
Rattink, A.P. ; Harlizius, B. ; Chardon, P. ; Faivre, M. ; Groenen, M.A.M. - \ 2000
In: Proceedings of the : XXVI International Conference on Animal Genetics (ISAG) - p. 46 - 46.
Major genes affecting backfat pigs : fine mapping of a paternally expressed QTL on chromosome 2
Rattink, A.P. ; Harlizius, B. ; Koning, D.J. de; Faivre, M. ; Joosten, R.G. ; Arendonk, J.A.M. van; Groenen, M.A.M. - \ 2000
In: Proceedngs : Plant and Animal Genome VIII Conference, San Diego - p. 149 - 149.
The -323Ins10 polymorphism for factor VII is not associated with coronary atherosclerosis in symptomatic men
Lievers, K.J.A. ; Mennen, L.I. ; Rattink, A.P. ; Zwinderman, A.H. ; Jukema, J.W. ; Schouten, E.G. ; Maat, M.P.M. de - \ 2000
Thrombosis Research 97 (2000). - ISSN 0049-3848 - p. 275 - 280.
Fine mapping of a paternally expressed QTL for backfat thickness on porcine chromosome 2
Harlizius, B. ; Rattink, A.P. ; Faivre, M. ; Jungerius, B. ; Keijzer, L. ; Joosten, R.G. ; Koning, D.J. de; Arendonk, J.A.M. van; Groenen, M.A.M. - \ 2000
In: book of abstracts : 51th meeting of the European Association of animal Production, The Hague, Wageningen : Wageningen Pers - p. 90 - 90.
The X chromosome harbors quantitative trait loci for backfat thickness and intramuscular fat content in pigs
Harlizius, B. ; Rattink, A.P. ; Koning, D.J. de; Faivre, M. ; Joosten, R.G. ; Arendonk, J.A.M. van; Groenen, M.A.M. - \ 2000
Mammalian Genome 11 (2000). - ISSN 0938-8990 - p. 800 - 802.
Genome-wide scan for body composition in pigs reveals important role of imprinting
Koning, D.J. de; Rattink, A.P. ; Harlizius, B. ; Arendonk, J.A.M. van; Brascamp, E.W. ; Groenen, M.A.M. - \ 2000
Proceedings of the National Academy of Sciences of the United States of America 97 (2000)14. - ISSN 0027-8424 - p. 7947 - 7950.
The role of imprinting in body composition was investigated in an experimental cross between Chinese Meishan pigs and commercial Dutch pigs. A whole-genome scan revealed significant evidence for five quantitative trait loci (QTL) affecting body composition, of which four were imprinted. Imprinting was tested with a statistical model that separated the expression of paternally and maternally inherited alleles. For back fat thickness, a paternally expressed QTL was found on Sus scrofa chromosome 2 (SSC2), and a Mendelian-expressed QTL was found on SSC7. In the same region of SSC7, a maternally expressed QTL affecting muscle depth was found. Chromosome 6 harbored a maternally expressed QTL on the short arm and a paternally expressed QTL on the long arm, both affecting intramuscular fat content. The individual QTL explained from 2 p to 10 f the phenotypic variance. The known homologies to human and mouse did not reveal positional candidate genes. This study demonstrates that testing for imprinting should become a standard procedure to unravel the genetic control of multifactorial traits.
Detection of QTL's controlling intramuscular and backfat in pigs
Rattink, A.P. ; Koning, D.J. de; Janss, L.L.G. ; Oers, P.A.M. van; Vries, B.J. de; Groenen, M.A.M. ; Poel, J.J. van der; Groot, P.N. de; Brascamp, E.W. ; Arendonk, J.A.M. van - \ 1999
In: Book of Abstracts of the XXVI International conference on Animal Genetics (ISAG). - [S.l.] : [s.n.], 1999. - (abstractnr. E043) - p. 106 - 106.
Detection of QTL's controlling intramuscular and backfat in pigs
Rattink, A.P. ; Koning, D.J. de; Janss, L.L.G. ; Oers, P.A.M. van; Vries, B.J. de; Groenen, M.A.M. ; Poel, J.J. van der; Groot, P.N. de; Brascamp, E.W. ; Arendonk, J.A.M. van - \ 1999
Animal Genetics (1999)supplement. - ISSN 0268-9146 - p. 69 - 69.
Deep-vein thrombosis is not associated with the P/S186 polymorphism of histidine-rich glycoprotein
Rattink, A.P. ; Hennis, B.C. ; Lievers, C.J.A. ; Maat, M.P.M. de; Bertina, R. ; Mennen, M.I. ; Rosendaal, F.R. - \ 1999
Fibrinolysis and Proteolysis 13 (1999)1. - p. 35 - 38.
A second maternally imprinted QTL affecting backfat thickness on chromosome 2 in pigs
Rattink, A.P. ; Harlizius, B. ; Koning, D.J. de; Faivre, M. ; Arendonk, J.A.M. van; Groenen, M.A.M. - \ 1999
In: Book of Abstracts NWO-MW Genetics retraite Rolduc, Kerkrade. - [S.l.] : [s.n.], 1999 - p. 1 - 1.
A second maternally imprinted QTL affecting backfat thickness on chromosome 2 in pigs
Rattink, A.P. ; Harlizius, B. ; Koning, D.J. de; Faivre, M. ; Arendonk, J.A.M. van; Groenen, M.A.M. - \ 1999
In: Abstract International Genomic Imprinting meeting, University college Dublin. - [S.l.] : [s.n.], 1999 - p. 37 - 37.
Detection of Quantitative Trait Loci for Backfat Thichness and Intramuscular Fat content in Pigs (Sus scrofa)
Koning, D.J. de; Janss, L.L.G. ; Rattink, A.P. ; Oers, P.A.M. van; Vries, B.J. de; Groenen, M.A.M. ; Poel, J.J. van der; Groot, P.N. de; Brascamp, E.W. ; Arendonk, J.A.M. van - \ 1999
Genetics 152 (1999). - ISSN 0016-6731 - p. 1679 - 1690.
In an experimental cross between Meishan and Dutch Large White and Landrace lines, 619 F(2) animals and their parents were typed for molecular markers covering the entire porcine genome. Associations were studied between these markers and two fatness traits: intramuscular fat content and backfat thickness. Association analyses were performed using interval mapping by regression under two genetic models: (1) an outbred line-cross model where the founder lines were assumed to be fixed for different QTL alleles; and (2) a half-sib model where a unique allele substitution effect was fitted within each of the 19 half-sib families. Both approaches revealed for backfat thickness a highly significant QTL on chromosome 7 and suggestive evidence for a QTL at chromosome 2. Furthermore, suggestive QTL affecting backfat thickness were detected on chromosomes 1 and 6 under the line-cross model. For intramuscular fat content the line-cross approach showed suggestive evidence for QTL on chromosomes 2, 4, and 6, whereas the half-sib analysis showed suggestive linkage for chromosomes 4 and 7. The nature of the QTL effects and assumptions underlying both models could explain discrepancies between the findings under the two models. It is concluded that both approaches can complement each other in the analysis of data from outbred line crosses.
Detection of quantitative trait loci for fatness traits in Dutch Meishan-crossbreds
Koning, D.J. de; Janss, L.L.G. ; Rattink, A.P. ; Groenen, M.A.M. ; Groot, P.N. de; Brascamp, E.W. ; Arendonk, J.A.M. van - \ 1999
In: 50th Annual Meeting EAAP, Zürich, Paper GPH1.6(1999) - p. 3 - 3.
Minder Pythium in komkommer
Postma, J. ; Rattink, H. - \ 1998
Groenten en Fruit. Vakdeel glasgroenten (1998)13 februari. - ISSN 1380-3573 - p. 4 - 5.
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