Toward the optimal strategy for sustained weight loss in overweight cancer survivors : a systematic review of the literature
Hoedjes, Meeke ; Stralen, Maartje M. van; Joe, Sheena Tjon A. ; Rookus, Matti ; Leeuwen, Flora van; Michie, Susan ; Seidell, Jacob C. ; Kampman, Ellen - \ 2017
Journal of Cancer Survivorship 11 (2017)3. - ISSN 1932-2259 - p. 360 - 385.
Behaviour change techniques - Cancer survivors - Lifestyle intervention components - Weight loss maintenance
Purpose: To gain more insight into the optimal strategy to achieve weight loss and weight loss maintenance in overweight and obese cancer survivors after completion of initial treatment, this systematic review aimed to provide an overview of the literature on intervention effects on weight, to describe intervention components used in effective interventions, to identify and synthesize behaviour change techniques (BCTs) and to assess the frequency with which these BCTs were used in effective interventions. Methods: Six databases were searched for original research articles describing weight changes in adult overweight cancer survivors after participation in a lifestyle intervention initiated after completion of initial treatment. Two researchers independently screened the retrieved papers and extracted BCTs using the BCT Taxonomy version 1. Results: Thirty-two papers describing 27 interventions were included. Interventions that were evaluated with a robust study design (n = 8) generally showed
No Effect of Red Clover-Derived Isoflavone Intervention on the Insulin-Like Growth Factor System in Women at Increased Risk of Colorectal Cancer
Vrieling, A. ; Rookus, M.A. ; Kampman, E. ; Bonfrer, J.M.G. ; Bosma, A. ; Cats, A. ; Doorn, J. van; Korse, C.M. ; Witteman, B.J.M. ; Leeuwen, F.E. van; van't Veer, L.J. ; Voskuil, D.W. - \ 2008
Cancer Epidemiology Biomarkers and Prevention 17 (2008)10. - ISSN 1055-9965 - p. 2585 - 2593.
healthy postmenopausal women - hormone replacement therapy - randomized controlled-trial - igf-binding-proteins - factor-i - prostate-cancer - soy protein - premenopausal women - antioxidant status - dna microarray
Background: Increased insulin-like growth factor (IGF)-I and IGF-II concentrations are related to increased colorectal cancer risk. Isoflavones have been associated with reduced colorectal cancer risk, and may affect the IGF system because of their weak estrogenic activity. The aim of the study was to investigate the effect of isolated isoflavones on serum concentrations of IGF system components. Materials and Methods: We conducted a randomized, placebo-controlled, double-blinded, crossover trial in four hospitals in the Netherlands to investigate the effect of an 8-week supplementation with red clover¿derived isoflavones (84 mg/d) on serum IGF-I concentrations. In addition, serum concentrations of IGF-II and IGF binding proteins (IGFBP)-1, IGFBP-2, and IGFBP-3 were assessed. Normal colorectal tissue biopsies were obtained after the first intervention period and mRNA expression of IGF-I, IGF-II, IGFBP-3, and IGF-IR was evaluated. Our study population consisted of 34 postmenopausal women with a family history of colorectal cancer or a personal history of colorectal adenomas. Results: Isoflavone supplementation did not significantly affect serum concentrations of total IGF-I (mean relative within-person difference; IGF-I, ¿2.0%; 95% confidence interval, ¿8.0% to 3.9%). IGF-II and IGFBPs were also not significantly altered after isoflavone supplementation. Colorectal tissue mRNA expression of IGF system components did not significantly differ between individuals on isoflavone supplementation and those who received placebo. Conclusions: The results of our trial, supported by a qualitative review of soy trials published to date, suggest that isoflavones do not significantly affect circulating levels of IGF system components. Increased levels of IGF-I, as observed in most of these trials, are likely due to simultaneous protein suppl
Lycopene supplementation elevates circulating insulin-like growth factor-binding protein-1 and-2 concentrations in persons at greater risk of colorectal cancer
Vrieling, A. ; Voskuil, D.W. ; Bonfrer, J.M. ; Korse, C.M. ; Doorn, J. ; Cats, A. ; Depla, A.C. ; Timmer, R. ; Witteman, B.J.M. ; Leeuwen, F.E. van; van't Veer, L.J. ; Rookus, M.A. ; Kampman, E. - \ 2007
American Journal of Clinical Nutrition 86 (2007)5. - ISSN 0002-9165 - p. 1456 - 1462.
factor-i - factor (igf)-i - factor system - igf-i - alpha-tocopherol - clinical-trial - human serum - c-peptide - dietary - carotenoids
Background: Higher circulating insulin-like growth factor I (IGF-I) concentrations have been related to a greater risk of cancer. Lycopene intake is inversely associated with cancer risk, and experimental studies have shown that it may affect the IGF system, possibly through an effect on IGF-binding proteins (IGFBPs). Objective: The objective of our study was to investigate the effect of an 8-wk supplementation with tomato-derived lycopene (30 mg/d) on serum concentrations of total IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3. Design: We conducted a randomized, placebo-controlled, double-blinded crossover study in 40 men and 31 postmenopausal women with a family history of colorectal cancer, a personal history of colorectal adenoma, or both. Results: Lycopene supplementation significantly (P = 0.01) increased serum IGFBP-1 concentrations in women (median relative difference between serum IGFBP-1 concentrations after lycopene supplementation and after placebo, 21.7%). Serum IGFBP-2 concentrations were higher in both men and women after lycopene supplementation than after placebo, but to a lesser extent (mean relative difference 8.2%; 95% CI: 0.7%, 15.6% in men and 7.8%; 95% CI: ¿5.0%, 20.6% in women). Total IGF-I, IGF-II, and IGFBP-3 concentrations were not significantly altered by lycopene supplementation. Conclusions: This is the first study known to show that lycopene supplementation may increase circulating IGFBP-1 and IGFBP-2 concentrations. Because of high interindividual variations in IGFBP-1 and IGFBP-2 effects, these results should be confirmed in larger randomized intervention studies
Isolated Isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk
Vrieling, A. ; Rookus, M.A. ; Kampman, E. ; Bonfrer, J.M.G. ; Korse, C.M. ; Doorn, J. van; Lampe, J.W. ; Cats, A. ; Witteman, B.J.M. ; Leeuwen, F.E. van; van't Veer, L.J. ; Voskuil, D.W. - \ 2007
The Journal of Nutrition 137 (2007)2. - ISSN 0022-3166 - p. 379 - 383.
estrogen replacement therapy - red-clover - factor-i - postmenopausal women - binding protein-3 - soy protein - clinical characteristics - premenopausal women - antioxidant status - human health
Epidemiological studies show that increased insulin-like growth factor (IGF)-I concentrations are related to increased colorectal cancer risk. A reduced colorectal cancer risk has been associated with isoflavones, which might affect the IGF-system because of their weak estrogenic activity. We conducted a randomized, placebo-controlled, double-blind crossover study to investigate the effect of an 8-wk isolated isoflavone supplementation (84 mg/d) on serum concentrations of total IGF-I, free IGF-I, total IGF-II, IGF binding protein (BP)-1, IGFBP-2, and IGFBP-3. Additionally, we investigated whether IGF-system component differences were related to concentrations of the more potent estrogenic isoflavone metabolite, equol. Our study population consisted of 37 men with a family history of colorectal cancer or a personal history of colorectal adenomas. Isoflavone supplementation did not significantly affect serum total IGF-I concentrations (relative difference between serum total IGF-I concentrations after isoflavone supplementation and after placebo: ¿1.3%, 95% CI ¿8.6 to 6.0%). Neither free IGF-I, nor total IGF-II, IGFBP-1, IGFBP-2, or IGFBP-3 concentrations were significantly altered. Interestingly, the change in serum IGF-I concentrations after isoflavone supplementation was negatively associated with serum equol concentrations (r = ¿0.49, P = 0.002). In conclusion, isolated isoflavones did not affect the circulating IGF-system in a male high-risk population for colorectal cancer. However, to our knowledge, this is the first study that suggests isoflavones might have an IGF-I lowering effect in equol producers only. This underlines the importance of taking into account equol status in future isoflavone intervention studies
Isoflavones do not affect the insulin-like growth factor (IGF) system in a trial in men with high colorectal cancer risk
Vrieling, A. ; Rookus, M.A. ; Kampman, E. ; Bonfrer, J.M.G. ; Korse, C.M. ; Doorn, J. ; Cats, A. ; Witteman, B.J.M. ; Leeuwen, F.E. van; Veer, P. van 't; Voskuil, D.W. - \ 2006
European Journal of Epidemiology 21 (2006)suppl.. - ISSN 0393-2990 - p. 107 - 108.
The Insulin-like Growth Factor System in Cancer Prevention: Potential of Dietary intervention Strategies
Voskuil, D.W. ; Vrieling, A. ; Veer, L.J. van 't; Kampman, E. ; Rookus, M.A. - \ 2005
Cancer Epidemiology Biomarkers and Prevention 14 (2005)1. - ISSN 1055-9965 - p. 195 - 203.
igf-binding protein-3 - factor-i levels - benign prostatic hyperplasia - breast-cancer - colorectal-cancer - lung-cancer - postmenopausal women - factor (igf)-i - c-peptide - cell-proliferation
The insulin-like growth factor (IGF) system is related to proliferation and tumor growth, and high levels of circulating IGF-I are thought to be a risk factor for several types of cancer. This review summarizes the epidemiologic evidence for an association between circulating IGF-I and cancer risk as well as the experimental evidence for a causal relation between the endocrine IGF system and tumor growth. The potential for dietary intervention to alter the IGF system and thereby cancer risk is supported by several lines of evidence. Postulated mechanisms of action are as follows: (a) reduction of levels of circulating IGF-I, which will decrease activation of the IGF-I receptor and subsequent signaling pathways; (b) increasing local IGF binding proteins, which may have IGF-dependent effects through obstruction of IGF interaction with local IGF-I receptor as well as IGF-independent effects; and (c) interference with estrogens and estrogen receptor action, which may have direct (and possibly synergistic) effects on IGF signaling. An overview is given of the epidemiologic studies on dietary determinants of circulating IGF-I. Examples of dietary factors, such as dairy protein, lycopene, and phytoestrogens, are used to illustrate the potential mode of action of dietary interventions that may act on the IGF system. In conclusion, the IGF system has every potential to serve as an intermediate for cancer (chemo)prevention studies. On the short term, more research initiatives aimed at the effects of specific food components or dietary strategies on the IGF system both in animal models and in humans are warranted.
|The association between alcohol consumption and breast cancer risk.
Rookus, M.A. ; Chorus, A.M.J. ; Nijboer, C. ; Schouten, E.G. ; Leeuwen, F.E. van - \ 1991
American Journal of Epidemiology 134 (1991)SER-abstracts. - ISSN 0002-9262 - p. 764 - 764.
|Alcoholgebruik en het risico op borstkanker.
Chorus, A.M.J. ; Nijboer, C. ; Schouten, E.G. ; Rookus, M.A. ; Leeuwen, F.E. van - \ 1991
Tijdschrift voor sociale gezondheidszorg 4 (1991)Middenkatern. - ISSN 0920-0517 - p. 34 - 35.
|Changes in body mass index in young adults in relation to number of life events experienced.
Rookus, M.A. ; Burema, J. ; Frijters, J.E.R. - \ 1988
International Journal of Obesity 12 (1988). - ISSN 0307-0565 - p. 29 - 39.
|The development of the Body Mass Index in young adults, II: Interrelationships of level, change and fluctuation, a four-year longitudinal study.
Rookus, M. ; Burema, J. ; Hof, M.A. van 't; Deurenberg, P. ; Hautvast, J.G.A.J. - \ 1987
Human biology 59 (1987). - ISSN 0018-7143 - p. 617 - 630.
|The development of Body Mass Index in young adults, I: Age-reference curves based on a four-year mixed-longitudinal study.
Rookus, M.A. ; Burema, J. ; Hof, M.A. van 't; Deurenberg, P. ; Wiel-Wetzels, W.A.M. van der; Hautvast, J.G.A.J. - \ 1987
Human biology 59 (1987). - ISSN 0018-7143 - p. 599 - 615.
Frame categories in weight-height tables.
Rookus, M.A. ; Burema, J. - \ 1987
American Journal of Public Health 77 (1987). - ISSN 0090-0036 - p. 94 - 94.
|Het ontstaan van matig overgewicht bij jonge volwassenen.
Rookus, M.A. - \ 1987
In: Voeding en overgewicht / de Boer, J.O., Deurenberg, P., van Gaal, L.F., Alphen aan den Rijn : Samson Stafleu - p. 79 - 89.
|Changes in Body Mass Index in young adults in relation to the number of live events experienced.
Rookus, M.A. ; Burema, J. ; Frijters, J. - \ 1987
International Journal of Obesity 11 (1987). - ISSN 0307-0565 - p. 605 - 615.
|The effect of pregnancy on the Body Mass Index 9 months postpartum in 49 women.
Rookus, M.A. ; Rookebrand, P. ; Burema, J. ; Deurenberg, P. - \ 1987
International Journal of Obesity 11 (1987). - ISSN 0307-0565 - p. 583 - 592.
|The development of the body mass index and the effect of dieting on this development in young Dutch adults, a four year follow-up study.
Rookus, M.A. ; Burema, J. ; Deurenberg, P. ; Hautvast, J.G.A.J. - \ 1986
In: Abstract 5th Int. Congr. Obesity, Jeruzalem (1986) 77a
|Obesity in North America and in The Netherlands.
Rookus, M.A. ; Deurenberg, P. ; Sonsbeek, J.L.A. van - \ 1986
The Lancet (1986). - ISSN 0140-6736 - p. 100 - 100.
|Life events, emotional eating and change in body mass.
Strien, T. van; Rookus, M.A. ; Bergers, G.P.A. ; Frijters, J.E.R. ; Defares, P.B. - \ 1986
International Journal of Obesity 10 (1986). - ISSN 0307-0565 - p. 29 - 35.
Body mass index in young Dutch adults : its development and the etiology of its development
Rookus, M.A. - \ 1986
Landbouwhogeschool Wageningen. Promotor(en): J.G.A.J. Hautvast; P. Deurenberg. - Wageningen : Roookus - 147
obesitas - overgewicht - jongvolwassenen - nederland - obesity - overweight - young adults - netherlands
Follow-up studies of long duration have shown a U-shaped relationship between mortality/morbidity and the body mass index (BMI, weight/height 2). The risk to health posed by obesity appears to be larger in younger subjects than in older subjects. Though this might suggest that a moderate weight gain after the termination of growth may not increase the risk to health, this contention is not supported by other observations (Chapter 1). These are: (1) the range of relative weight associated with minim= mortality does not seem to shift to higher values with increasing age, at least not in men. (2) Diseases associated with overweight at younger ages need not be the same as those associated with overweight at older ages. (3) Cohort effects may bias the age trend in the risk associated with overweight. (4) Longitudinal studies on adults show that changes in body weight are associated with changes in risk factors of diseases. (5) Anthropometric studies show that even at the same weight, the fat mass increases with increasing age. In addition, several studies suggest that weight gained during adulthood mainly accumulates in the abdomen, which means a shift to a fat distribution more strongly associated with risk to health. The risk to health therefore does not seem to remain constant if body weight increases during adulthood.
As part of an extensive mixed-longitudinal study (Chapter 2), this thesis deals with the development of the BMI and the etiology of this development in young adults. In addition, one methodological study is described. These studies build m cross-sectional observations that were made in the first examination of the study.
In spring 1980, all residents of Dutch nationality in the county of Ede, born in 1948-1950, 1953-1955, 1958-1960 were invited by mail to participate in the study. Participants in spring 1980 (N=3936) were followed for four years (1980-1984) in two groups, the follow-up group (N=1670) and the control group (N=2266). From spring 1981 onward the follow-up group was approached twice a year in seven consecutive examinations. The control group was re-measured in spring 1984 only. At each examination a questionnaire was completed and body weight in light indoor clothing and without shoes was measured to the nearest 0.5 kg. Body height was measured to the nearest 0.1 cm in spring 1980. Subgroups of the follow-up and control groups were additionally examined for the studies described in Chapter 7 and 8.
The development of the BMI is dealt with in Chapter 3, in which the mixed-longitudinal design of the study was utilized, and Chapter 4, in which the data were analyzed longitudinally. Over the four years, the change in BMI of the follow-up group was the same as that of the control group. Prom 19 to 35 years of age the median BMI increased from 22.1 kg/m 2to 24.4 kg/m 2in men and from 21.1 kg/m 2to 23.0 kg/m 2in women (Chapter 3). This increment in BMI gave rise to an incidence of moderate overweight (BMI>25 kg/m 2) which increased from 4.8% per 4 years to 15.5% per 4 years in men, and was more stable (5.3-5.7% per 4 years) in women (Chapter 4). Thus, especially in men, young adulthood appears to be a critical period for the development of overweight.
The age-reference curves (Chapter 3) suggested that the variation of the BMI over subjects was independent of age. In accordance, the longitudinal analyses showed that the initial BMI and the rate of gain in BMI were unrelated in men and only slightly negatively related in women. Thus, overweight subjects did not appear to gain more or less body mass than non-overweight subjects.
The within-subjects standard deviation of the yearly measured BMI was 0.69 kg/m 2in men and 0.74 kg/m 2in women (Chaper 4). This fluctuation was larger in overweight subjects than in normal-weight subjects and was larger in subjects with a larger long-term change (gain or loss) in BMI than in subjects who had a more stable BMI. The considerable fluctuation in BMI may mask the gradual long-term increment in BMI and may thus hinder young adults from being aware that they are becoming overweight.
The effect of dieting is dealt with in Chapter 5. After two years of follow-up, the average decrease in body mass as a result of dieting was -0.5 kg/m 2(95% confidence interval (CI):-1.0,+0.0) in men and -0.4 kg/m 2(95%CI:-0.8,+0.0) in women. This approximately amounts to an average weight reduction of 1.5 kg in men and 1.0 kg in women. The effect of dieting was most pronounced in men whose initial BMI was high, who dieted during the summer, or who dieted more frequently, and in women who were older than 30 or who dieted on medical advice. Though subjects who have already developed severe overweight may achieve a larger reduction in the risk to health by losing the same amount of body mass as subjects who are only moderately overweight, it is unlikely that the benefit is large unless they persist. However, the effect of dieting may be enough to prevent the age-related gain in body mass and thus dieting may especially play a part in the prevention of overweight.
Chapter 6 deals with the changes in BMI in relation to number of life events experienced. During the first year of follow-up several subgroups of men and women who experienced many life events and several subgroups of men who experienced few life events showed a gain in body mass. After another year of follow-up this gain in body mass had disappeared in almost all subgroups; compared with dieting ran with an intermediate number of life events, dieting men with few life events gained +1.3 kg/m 2(95%CI:+0.0,+2.6) more body mass, whereas dieting men with many life events gained +1.8 kg/m 2(95%CI: +0.5,+3.0) more body mass. Thus, life events seem to have an impact on the etiology of overweight in men.
One life event in women is considered more specifically (Chapter 7); i.e. pregnancy. Women who breastfed their child for more than two months gained more body mass than was expected from aging. Nine months postpartum they were +0.6 kg/m 2(90%CI: +0.1,+1.0) heavier than expected. This difference was slightly smaller (not significantly) in women who breastfed their child for 0-2 months. Women who used bromocriptine to stop lactation lost body mass unexpectedly.
In a methodological study (Chapter 8) the impact of adjustment of the BMI for body diameters (i.e. knee, wrist, elbow, shoulder, pelvis and hip) on the prediction of body fatness was examined. In addition to what was explained by the BMI, 6% of the variation in body fatness was explained by the shoulder diameter in men, and also 6% by the knee diameter in women. This improvement in estimating body fatness by the diameters, used as continuous variables, was considered too small to justify frame categories being included in weight-height tables. Instead of frame size, fat distribution might be a more useful attribute in these tables.
In the last chapter (Chapter 9) several aspects relating to the validity of the mixed-longitudinal study are discussed. The main conclusions of this thesis are:
The impact of adjustment of a weight-height index (W/H2) for frame size on the prediction of body fatness
Rookus, M.A. ; Burema, J. ; Deurenberg, P. ; Wiel-Wetzels, W.A.M. van der - \ 1985
The British journal of nutrition 54 (1985)2. - ISSN 0007-1145 - p. 335 - 342.