Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Monstername voor voedselveiligheid
    Schans, M.G.M. van de; Giezenaar, Edwin ; Berendsen, B.J.A. - \ 2020
    Antibioticaresistente bacterien, resistentiegenen en antibiotica residuen in mest
    Schmitt, H. ; Blaak, H. ; Hoeksma, P. ; Schans, M.G.M. van de; Kemper, M. ; Rijk, S. de; Roda Husman, A.M. de - \ 2019
    Wageningen University & Research (RIVM briefrapport 2019-0112)
    Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
    Hendriksen, Rene S. ; Munk, Patrick ; Njage, Patrick ; Bunnik, Bram van; Mcnally, Luke ; Lukjancenko, Oksana ; Röder, Timo ; Nieuwenhuijse, David ; Pedersen, Susanne Karlsmose ; Kjeldgaard, Jette ; Schans, Milou van de; Zuidema, Tina ; Aarestrup, Frank M. - \ 2019
    Technical University of Denmark
    ERP015409 - PRJEB13831 - wastewater metagenome
    Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
    Circulaire systemen
    Bos, Harriëtte ; Groenestijn, John van; Harmsen, Paulien ; Hugenholtz, Jeroen ; Appelmans, Wilfred ; Jetten, Jan ; Bussmann, Pauil ; Bon, Jeroen van; Burgering, Maurits ; Verdoes, Nico ; Groenestein, Karin ; Duinkerken, Gert van; Fels-Klerx, Ine van der; Schans, Milou van de; Gerrits, Elise ; Schoumans, Oscar ; Haas, Wim de; Regelink, Inge ; Stuiver, Marian ; Bakker, Sjaak ; Dijk, Wim van; Visser, Saskia - \ 2019
    Wageningen : Wageningen University & Research - 41
    Veterinary pharmaceuticals and natural hormones in the environment after field applications of slurry
    Lahr, J. ; Derksen, A. ; Wipfler, E.L. ; Schans, M.G.M. van de; Berendsen, B. ; Blokland, M. ; Dimmers, W.J. ; Bolhuis, P. ; Smidt, R. - \ 2019
    Korte keten kan impulsen gebruiken
    Schans, Jan Willem van der - \ 2019
    Prosumptie in de polder: een verkenning van de zelf voedsel producerende consument in Almere
    Veen, Esther ; Jansma, Jan Eelco ; Dagevos, Hans ; Schans, Jan Willem van der - \ 2019
    Wageningen : Stichting Wageningen Research, Wageningen Plant Research (Rapport WPR 799) - 69
    Korte ketens in Gelderland
    Schans, J.W. van der; Wonderen, D. van - \ 2019
    Wageningen : Wageningen Economic Research (Wageningen Economic Research Nota 2019-072) - 39
    This report provides a picture of the size and distribution of short supply chains for agricultural products in the Province of Gelderland. First we define short food supply chains in the context of the Common Agricultural Policy. Then we look at the size of short food supply chains in Gelderland: which sectors and municipalities are taking the lead? Furthermore, some additional attributes of short food supply chains have been analysed: farm size, whether or not there is a successor for the farm, etc. The relations between multi-functional farming activities and short food supply chains have also been analysed. Lastly, the dynamics of farm sales have been analysed, as an example of a short food supply chain which is relatively well documented.
    Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
    Hendriksen, Rene S. ; Munk, Patrick ; Njage, Patrick ; Bunnik, Bram Van; Mcnally, Luke ; Lukjancenko, Oksana ; Röder, Timo ; Nieuwenhuijse, David ; Pedersen, Susanne Karlsmose ; Kjeldgaard, Jette ; Kaas, Rolf S. ; Clausen, Philip Thomas Lanken Conradsen ; Vogt, Josef Korbinian ; Leekitcharoenphon, Pimlapas ; De Schans, Milou G.M. Van; Zuidema, Tina ; Roda Husman, Ana Maria De; Rasmussen, Simon ; Petersen, Bent ; Amid, Clara ; Cochrane, Guy ; Sicheritz-ponten, Thomas ; Schmitt, Heike ; Alvarez, Jorge Raul Matheu ; Aidara-kane, Awa ; Pamp, Sünje J. ; Lund, Ole ; Hald, Tine ; Woolhouse, Mark ; Koopmans, Marion P. ; Vigre, Håkan ; Petersen, Thomas Nordahl ; Aarestrup, Frank M. - \ 2019
    Nature Communications 10 (2019)1. - ISSN 2041-1723 - 12 p.
    Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use meta-genomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
    A new extraction procedure to abate the burden of non-extractable antibiotic residues in manure
    Jansen, Larissa J.M. ; Schans, Milou G.M. van de; Boer, Diana de; Bongers, Irma E.A. ; Schmitt, Heike ; Hoeksma, Paul ; Berendsen, Bjorn J.A. - \ 2019
    Chemosphere 224 (2019). - ISSN 0045-6535 - p. 544 - 553.
    Antibiotics - Extraction - LC-MS - Manure - Non-extractable residues

    Through agricultural soil fertilization using organic manure, antibiotic residues can accumulate in the environment. In order to assess the risks of environmental pollution by veterinary drugs, monitoring of manure for antibiotic residues is necessary. As manure is a complex matrix, extraction of antibiotics proved to be challenging. In this study, 24 extraction solvents were assessed for the extraction of residues from manure representing ten antibiotics from the antibiotic classes tetracyclines, quinolones, macrolides, lincosamides and sulfonamides. Especially for the tetracyclines and quinolones the extraction solvent selection is critical, due to high fractions of non-extractable residues especially when using aqueous solvents (62–77% and 90–95% respectively when using milli-Q water). In contrast, sulfonamides can effectively be extracted with aqueous solvents. Overall, 0.125% trifluoroacetic acid in acetonitrile in combination with McIlvain-EDTA buffer proved to be the most effective extraction solvent. A longitudinal study pointed out that most antibiotics bind to solid manure particles instantaneously after addition. Trimethoprim is an exception, but because by using the optimal extraction solvent, the optimum fraction of bound residues is desorbed, this does not hamper quantitative analysis when using spiked manure quality control samples. Based on these new insights, the current in-house multi-residue LC-MS/MS method for manure analysis, containing 48 antibiotics, was revised, additionally validated and applied to 34 incurred manure samples.

    Vertical Farming : teelt en keten
    Wubben, E.F.M. ; Schans, J.W. van der; Gelder, A. de; Looman, B.H.M. ; Nijman, J. - \ 2019
    Groen Kennisnet
    Dit leerboek is ontwikkeld is het resultaat van het WURKS-project Vertical Farming – teelt en keten. Het leerboek is gemaakt binnen de wiki-omgeving van Groen Kennisnet en is bedoeld voor MBO en HBO.
    Beta-lactamase supplementation, a feasible mitigation strategy for antibiotics in colostrum
    Pikkemaat, M.G. ; Laar-Robbertsen, Jacoline van; Boer, Diana de; Schans, M.G.M. van de - \ 2018
    Comprehensive two-dimensional LC QTOF MS for residue analysis of sulfonamides, beta-agonists and steroids
    Blokland, M.H. ; Zoontjes, P.W. ; Ginkel, L.A. van; Schans, M.G.M. van de; Sterk, S.S. ; Bovee, T.F.H. - \ 2018
    The fate of ivermectine in soil
    Berendsen, B.J.A. ; Arends, Maura ; Schans, M.G.M. van de; Zuidema, T. - \ 2018
    The persistence of a broad range of antibiotics during calve, pig and broiler manure storage.
    Berendsen, B.J.A. ; Lahr, J. ; Nibbeling, C.V.M. ; Jansen, L.J.M. ; Bongers, Irma ; Wipfler, E.L. ; Schans, M.G.M. van de; Zuidema, T. - \ 2018
    SIP (2017) MS-based molecular mapping for longitudinal residue monitoring
    Schans, M.G.M. van de - \ 2018
    SIP (2017) Development of mitigation strategies for antibiotics in colostrum
    Schans, M.G.M. van de - \ 2018
    Oral presentation
    Schans, M.G.M. van de - \ 2018
    WURKS “Consumer connections short food chains”
    Kortstee, Harry ; Schans, Jan Willem van der; Verstegen, Jos ; Splinter, Gerben ; Sijtsema, Siet ; Snoek, Harriëtte - \ 2018
    Wageningen : Wageningen University & Research (Wageningen University & Research 2018-107) - 62
    Multiclass screening in urine by comprehensive two-dimensional liquid chromatography time of flight mass spectrometry for residues of sulphonamides, beta-agonists and steroids
    Blokland, M.H. ; Zoontjes, P.W. ; Ginkel, L.A. van; Schans, M.G.M. van de; Sterk, S.S. ; Bovee, T.F.H. - \ 2018
    Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment 35 (2018)9. - ISSN 1944-0049 - p. 1703 - 1715.
    Antibiotics - comprehensive 2D-LC - growth promoters - LC x LC - mass spectrometry - residues

    Nowadays routine residue monitoring involves the analysis of many compounds from different classes, mainly in urine. In the past two decades, developments heavily focused on the use of mass spectrometers (MS) and faster and more sensitive MS detectors have reached the market. However, chromatographic separation (CS) was rather ignored and the cognate developments in CS were not in line. As a result, residue analysis did not improve to the extent anticipated. CS by LC x LC is a promising technique and will enable a further increase in the range of compounds and compound classes that can be detected in a single run. In the present study, a self-built LC x LC system, using a 10 port valve, was connected to a single quadrupole MS with electrospray interface. Standards containing a mixture of sulphonamides, β-agonists and (steroid) hormones, 53 compounds, in total, were analysed. Results demonstrated that these compounds were well separated and could be detected at low levels in urine, i.e. limit of detection (LOD) from 1 µg L−1 for most β-agonists to 10 µg L−1 for some sulphonamides and most hormones. To enhance the sensitivity, optimisation was performed on an advanced commercial LC x LC system connected to a full scan accurate MS. This ultimately resulted in a fast high throughput untargeted method, including a simple sample clean-up in a 96-well format, for the analysis of urine samples.

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