Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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EFSA Scientific Colloquium 24 – 'omics in risk assessment: state of the art and next steps
Aguilera, Jaime ; Aguilera‐gomez, Margarita ; Barrucci, Federica ; Cocconcelli, Pier Sandro ; Davies, Howard ; Denslow, Nancy ; Lou Dorne, Jean ; Grohmann, Lutz ; Herman, Lieve ; Hogstrand, Christer ; Kass, George E.N. ; Kille, Peter ; Kleter, Gijs ; Nogué, Fabien ; Plant, Nick J. ; Ramon, Matthew ; Schoonjans, Reinhilde ; Waigmann, Elisabeth ; Wright, Matthew C. - \ 2018
EFSA Supporting Publications 15 (2018)11. - ISSN 2397-8325
In recent years, the development of innovative tools in genomics, transcriptomics, proteomics and metabolomics (designated collectively as 'omics technologies) has opened up new possibilities for applications in scientific research and led to the availability of vast amounts of analytical data. The interpretation and integration of 'omics data can provide valuable information on the functional status of an organism and on the effect of external factors such as stressors. The European Food Safety Authority's (EFSA) 24th Scientific Colloquium on 'omics in risk assessment: state of the art and next steps explored the opportunities for integration of datasets produced via specific 'omics tools within the remit of EFSA's risk assessment approaches and tried to build further towards concrete paths of implementation. Discussions focused on genomics in microbial strain characterisation, metabolomics for the comparative assessment of GM plants and the use of 'omics for toxicological and environmental risk assessment. From the Colloquium it became clear that 'omics technologies are a valuable addition in some aspects of risk assessment of food and feed products and the environment, especially now that this technology is almost mature and stable. However, a consistent reporting framework for data collection, processing, interpretation, storage and curation should be further drawn up together with national and international organisations before 'omics technologies can be routinely used in risk assessment. For 'omics datasets in chemical and environmental risk assessments, the use of 'omics technologies alongside current toxicological or environmental risk assessment approaches is needed to re‐inforce confidence and expertise before implementation of these datasets as a standalone tool in risk assessment. Test cases could be worked out to enhance confidence in the use of 'omics datasets in risk assessment.
Guidance to develop specific protection goal options for environmental risk assessment at EFSA, in relation to biodiversity and ecosystem services
Brock, T.C.M. ; Hogstrand, C. ; Luttik, R. ; Hardy, T. ; Perry, J. ; Romeis, J. ; Werf, W. van der; Devos, Y. ; Maggiore, A. ; Rortais, A. ; Schoonjans, R. ; Streissl, F. ; Tarazona, J. ; Tramontini, S. ; Vettori, M.V. - \ 2016
EFSA Journal 14 (2016)6. - ISSN 1831-4732 - 50 p.
Maintaining a healthy environment and conserving biodiversity are major goals of environmental protection. A challenge is that protection goals outlined in legislation are often too general and broad to be directly applicable for environmental risk assessment (ERA) performed by EFSA. Therefore, they need to be translated into specific protection goals (SPGs). This Guidance presents a framework, which accounts for biodiversity and ecosystem services, to make general protection goals operational for use in all areas of EFSA's ERAs. The approach to follow has three sequential steps: (1) the identification of relevant ecosystem services; (2) the identification of service providing units (SPUs) for these ecosystem services; and (3) the specification of options for the level/parameters of protection of the SPUs using five interrelated dimensions. This last step involves the specification of options for the ecological entity and attribute to protect and the magnitude, temporal scale and spatial scale of the biologically relevant and, in the case of regulated products, tolerable effects, the latter defined in dialogue with risk managers. In order to promote transparency and consistency when developing options for the level/parameters of protection, this guidance provides considerations to justify the selected options.
Nanomaterials for products and application in agriculture, feed and food
Peters, Ruud J.B. ; Bouwmeester, Hans ; Gottardo, Stefania ; Amenta, Valeria ; Arena, Maria ; Brandhoff, Puck ; Marvin, Hans J.P. ; Mech, Agnieszka ; Moniz, Filipa Botelho ; Pesudo, Laia Quiros ; Rauscher, Hubert ; Schoonjans, Reinhilde ; Undas, Anna K. ; Vettori, Maria Vittoria ; Weigel, Stefan ; Aschberger, Karin - \ 2016
Trends in Food Science and Technology 54 (2016). - ISSN 0924-2244 - p. 155 - 164.
Agriculture - Application - Feed - Food - Nanomaterial - Products - Risk assessment

Background: Nanotechnology applications can be found in agricultural production, animal feed, food processing, food additives and food contact materials (hereinafter referred to as agri/feed/food). A great diversity of nanomaterials is reported to be currently used in various applications, while new nanomaterials and applications are reported to be in development. Scope and approach: It is expected that applications of nanomaterials in agri/feed/food will increase in the future and thereby increase the human and environmental exposure to such materials. To gain up-to-date knowledge we explored and reviewed the already marketed and in-development applications of nanomaterials in the agri/feed/food sectors upon the request of the European Food Safety Authority (EFSA). In this paper the results of the project are highlighted and discussed in more detail. Key findings and conclusions: The majority of the applications of nanomaterials that we identified concerned application in food as food additives and food contact materials, while much fewer applications seem to be developed for agriculture and feed. Nano-encapsulates, silver, titanium dioxide and silica are the most often mentioned nanomaterials in the literature. About half of the identified applications are claimed to be already in use. In-development applications are found for nano-encapsulates and nano-composites in novel foods, food and feed additives, biocides, pesticides and food contact materials.

Nanomaterials in Food - Current and Future Applications and Regulatory Aspects
Aschberger, K. ; Gottardo, S. ; Amenta, V. ; Arena, M. ; Botelho Moniz, F. ; Bouwmeester, Hans ; Brandhoff, P. ; Mech, A. ; Quiros Pesudo, L. ; Rauscher, H. ; Schoonjans, R. ; Vittoria Vettori, M. ; Peters, R. - \ 2015
Journal of Physics: Conference series 617 (2015)1. - ISSN 1742-6588

Nanotechnology can contribute to the development of innovative applications in the agriculture, food and feed sector by e.g. enabling improved delivery of nutrients or increased efficacy of agrichemicals. It is expected that applications will increase in the near future and may therefore become a relevant source of human exposure to nanomaterials (NM). To gain more up-to date information, RIKILT and the Joint Research Centre (JRC) were commissioned by the European Food Safety Authority (EFSA) to prepare an inventory of currently used and reasonably foreseen applications of NM in agriculture and food/feed production and carried out a review of regulatory aspects concerning NM in both EU and non-EU countries. An analysis of the information records in the inventory shows that nano-encapsulates, silver and titanium dioxide are the most frequent type of NM listed and that food additives and food contact materials are the most frequent types of application. A comparison between marketed applications and those in development indicates a trend from inorganic materials (e.g. silver) towards organic materials (nano-encapsulates, nanocomposites). Applications in novel food, feed additives, biocides and pesticides are currently mostly at a developmental stage. The review of EU and non-EU legislation shows that currently a few EU legal acts incorporate a definition of a nanomaterial and specific provisions for NM, whereas in many non-EU countries a broader approach is applied, which mainly builds on guidance for industry.

Optimising environmental risk assessments : Accounting for ecosystem services helps to translate broad policy protection goals into specific operational ones for environmental risk assessments
Devos, Y. ; Romeis, J. ; Luttik, R. ; Maggiore, A. ; Perry, J.N. ; Schoonjans, R. ; Streissl, F. ; Tarazona, J. ; Brock, T.C.M. - \ 2015
Embo Reports 16 (2015)9. - ISSN 1469-221X - p. 1060 - 1063.
Regulatory aspects of nanotechnology in the agri/feed/food sector in EU and non-EU countries
Amenta, V. ; Aschberger, K. ; Arena, M. ; Bouwmeester, H. ; Botelho Moniz, F. ; Brandhoff, P. ; Gottardo, S. ; Marvin, H.J.P. ; Mech, A. ; Quiros Pesudo, L. ; Rauscher, H. ; Schoonjans, R. ; Vettori, M.V. ; Weigel, S. ; Peters, R.J.B. - \ 2015
Regulatory Toxicology and Pharmacology 73 (2015)1. - ISSN 0273-2300 - p. 463 - 476.
Nanotechnology has the potential to innovate the agricultural, feed and food sectors (hereinafter referred to as agri/feed/food). Applications that are marketed already include nano-encapsulated agrochemicals or nutrients, antimicrobial nanoparticles and active and intelligent food packaging. Many nano-enabled products are currently under research and development, and may enter the market in the near future. As for any other regulated product, applicants applying for market approval have to demonstrate the safe use of such new products without posing undue safety risks to the consumer and the environment. Several countries all over the world have been active in examining the appropriateness of their regulatory frameworks for dealing with nanotechnologies. As a consequence of this, different approaches have been taken in regulating nano-based products in agri/feed/food. The EU, along with Switzerland, were identified to be the only world region where nano-specific provisions have been incorporated in existing legislation, while in other regions nanomaterials are regulated more implicitly by mainly building on guidance for industry. This paper presents an overview and discusses the state of the art of different regulatory measures for nanomaterials in agri/feed/food, including legislation and guidance for safety assessment in EU and non-EU countries
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