Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Willen de wolven zich melden, alsjeblieft?
Jansman, H.A.H. - \ 2019
Hoe erg is het stikstofprobleem?
Vries, W. de - \ 2019
Valuing biomarker diagnostics for dementia care: enhancing the reflection of patients, their care-givers and members of the wider public
Burg, Simone van der; Schreuder, Floris H.B.M. ; Klijn, Catharina J.M. ; Verbeek, Marcel M. - \ 2019
Medicine, Health Care and Philosophy 22 (2019)3. - ISSN 1386-7423 - p. 439 - 451.
Care - Cure - Dementia - Early diagnostics - Ethics - Stakeholder discussion

What is the value of an early (presymptomatic) diagnosis of dementia in the absence of effective treatment? There has been a lively scholarly debate over this question, but until now (future) patients have not played a large role in it. Our study supplements biomedical research into innovative diagnostics with an exlporation of its meanings and values according to (future) patients. Based on seven focusgroups with (future) patients and their care-givers, we conclude that stakeholders evaluate early diagnostics with respect to whether and how they expect it to empower their capacity to (self-) care. They value it, for instance, with respect to whether it (a) explains experienced complaints, (b) allows to start a process of psychological acceptance and social adaptation to the expected degeneration, (c) contributes to dealing with anxieties (with respect to inheritable versions of dementia), (d) informs adequately about when to start preparing for the end of life, (d) informs the planning of a request for euthanasia, or (e) allows society to deal with a growing amount of dementia patients. Our study suggests that information about disease is considered ‘harmful’ or ‘premature’ when recipients feel unable to act on that information in their (self-) care. The results of this research offers input to further ethical research. It invites to adopt a care perspective in evaluation and to seek ways to prevent the ‘harm’ that such diagnostic methods can bring about.

BIOFOS: micro-ring resonator-based biophotonic system for food analysis. Nut mycotoxin detection
Romero, A. ; Ninot, A. ; Hermoso, J.F. ; Zergioti, I. ; Kouloumentas, Ch. ; Avramopoulos, H. ; Leeuwis, H. ; Schreuder, E. ; Graf, S. ; Knapp, H. ; Barthelmebs, L. ; Noguer, T. ; Tsekenis, G. ; Scheres, L. ; Smulders, M. ; Zuilhof, H. ; Heesink, G. ; Reguillo, L. ; Risquez, A. - \ 2018
In: Proceedings of the 7th International Symposium on Almonds and Pistachios. - International Society for Horticultural Science (Acta Horticulturae ) - ISBN 9789462612167 - p. 339 - 343.
Analysis of aflatoxin B1 - Biosensor - Food safety

BIOFOS aims to further develop and validate a reusable and high-added value Lab-on-Chip (LoC) based, micro-biophotonic sensor platform for in situ monitoring of food contaminants. The Lab-on-Chip was tested on milk (aflatoxin M1, antibiotics and lactose), olive oil (pesticides and metals), nuts (aflatoxin B1) and dehydrated fruits (ochratoxin A). BIOFOS combines the most promising concepts from the photonic, biological, nanochemical and fluidic parts of Lab-on-Chip systems, aiming to achieve low sensitivity and high specificity, excellent reliability and compactness. Current methodologies for detection of food contamination based on heavy analytical tools cannot guarantee a safe and stable food supply. The reasons are the complexity, the long time-to-result (2-3 days) and the cost of these tools, which limit the number of samples that can be practically analyzed at food processing and storage sites. Preliminary results for almonds spiked with aflatoxin B1 are presented. First results suggest that BIOFOS has sensitivity enough for AFB1, even that the concentration is at ppb level. More data are still required, and many analyses are ongoing in the laboratory. Results are not enough to conclude about any characteristics of the device performance, even then repeatability seems very good (variation less than 3% at 25 ppb) and recovery is acceptable (78.4%), while decision limit and detection capability are still uncertain.

Functional intron-derived miRNAs and host-gene expression in plants
Shapulatov, Umidjon ; Hoogdalem, M.D. van; Schreuder, M.E.L. ; Bouwmeester, H.J. ; Abdurakhmonov, Ibrokhim Y. ; Krol, A.R. van der - \ 2018
Plant Methods 14 (2018). - ISSN 1746-4811
Background: Recently, putative pre-miRNAs locations have been identified in the introns of plant genes, raising the question whether such genes can show a dual functionality by having both correct maturation of the host gene pre-mRNA and maturation of the miRNAs from the intron. Here, we demonstrated that such dual functionality is indeed possible, using as host gene the firefly luciferase gene with intron (ffgLUC), and different artificial intronic miRNAs (aimiRNA) placed within the intron of ffgLUC. Results: The miRNAs were based on the structure of the natural miR319a. Luciferase (LUC) activity in planta was used to evaluate a correct splicing of the ffgLUC mRNA. Different target sequences were inserted into the aimiRNA to monitor efficiency of silencing of different target mRNAs. After adjusting the insertion cloning strategy, the ffgLUCaimiR-319a gene showed dual functionality with correct splicing of ffgLUC and efficient silencing of TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR1 transcription factor genes targeted in-trans by aimiR-319a or targeting the transgene ffLUC in-cis by an aimiR-LUC. Silencing of endogenous target genes by aimiRNA or amiRNA is efficient both in transient assays and stable transformants. A behave as strong phenotype the PHYTOCHROME B (PHYB) gene was also targeted by ffgLUCaimiR-PHYB. The lack of silencing of the PHYB target was most likely due to an insensitive target site within the PHYB mRNA which can potentially form a double stranded stem structure. Conclusion: The combination of an overexpression construct with an artificial intronic microRNA allows for a simultaneous dual function in plants. The concept therefore adds new options to engineering of plant traits that require multiple gene manipulations.
Droogte: Hoe stoppen we de verzilting van Nederland?
Blom-Zandstra, Greet - \ 2018
Boer zoekt toekomst
Wiskerke, Han - \ 2018

Met deze speciale uitzending van Spraakmakers komen we vanochtend vanaf de boerderij van Arend Heida in de Flevopolder. Aanleiding is een groot onderzoek van dagblad Trouw, waarin boeren aangeven dat ze graag meer rekening willen houden met natuur, milieu en ons landschap. Alleen, dat vergroenen is lang niet altijd makkelijk blijkt. In het eerste deel van deze uitzending praten we over de uitkomsten van het onderzoek van Trouw met Hans Marijnissen, Han Wiskerke en boeren Johan Leenders, Heleen Lansink, Arend Heida en Harry Schreuder

BIOFOS: A micro-ring resonator-based biophotonic system for food analysis - Application to olive oil contaminants
Romero, A. ; Ninot, A. ; Hermoso, J.F. ; Zergioti, I. ; Kouloumentas, C. ; Avramopoulos, H. ; Leeuwis, H. ; Schreuder, E. ; Graf, S. ; Knapp, H. ; Barthelmebs, L. ; Noguer, T. ; Tsekenis, G. ; Scheres, L. ; Smulders, M. ; Zuilhof, H. ; Heesink, G. ; Reguillo, L. - \ 2018
In: Proceedings of the 8th International Olive Symposium. - International Society for Horticultural Science (Acta Horticulturae ) - ISBN 9789462611955 - p. 505 - 509.
Analysis of pesticides and heavy metals - Copper - Oil quality - Organophosphates

Current detection methods for contaminants in food use high-tech equipment sited in specialized laboratories. This makes online quality control along the food chain difficult. Official regulations limit pesticide and heavy-metal contamination, mainly for organic production, although their analysis is quite expensive, requires skilled personnel and is very difficult to apply to a large number of oil batches. The BIOFOS Project (ICT-FP7-GA.N.611528) aims to develop and validate a Lab-on-a-Chip (LoC) multianalyser, based on micro-biophotonic sensors, for in-situ food contaminant analysis. This device includes biosensors for milk analysis (aflatoxin M1, antibiotic and lactose), nuts (aflatoxin B1), dried fruits (ochratoxin A) and olive oil (organophosphates and metals). BIOFOS combines four high-tech platforms: (1) a photonic platform based on micro-ring resonators (MRR) for signal quantification, (2) a biological platform based on aptamers for analyte detection, (3) a nanochemical platform to immobilize aptamers onto the chip surface and (4) a microfluidic platform for sample pre-treatment and its loading into the biosensor. The project is organized in work packages in order to develop the technological platforms. End-user requirements are also considered, as well as existing fast analysis kits that will be compared against the device. Validation protocols and exploitation plans are also included. BIOFOS applications for olive oil analysis are discussed, in terms of accuracy, sensitivity, time-to-result and cost per sample.

Improvements in fitness are not obligatory for exercise training-induced improvements in CV risk factors
Hartman, Yvonne A.W. ; Hopman, Maria T.E. ; Schreuder, Tim H. ; Verheggen, Rebecca J.H.M. ; Scholten, Ralph R. ; Oudegeest-Sander, Madelijn H. ; Poelkens, Fleur ; Maiorana, Andrew J. ; Naylor, Louise H. ; Willems, Peter H. ; Tack, Cees J. ; Thijssen, Dick H.J. ; Green, Daniel J. - \ 2018
Physiological Reports 6 (2018)4. - ISSN 2051-817X
Cardiovascular diseases - exercise training - physical fitness - risk factors
The purpose of this study was to assess whether changes in physical fitness relate to changes in cardiovascular risk factors following standardized, center-based and supervised exercise training programs in subjects with increased cardiovascular risk. We pooled data from exercise training studies of subjects with increased cardiovascular risk (n = 166) who underwent 8–52 weeks endurance training. We determined fitness (i.e., peak oxygen uptake) and traditional cardiovascular risk factors (body mass index, blood pressure, total cholesterol, high-density lipoprotein cholesterol), before and after training. We divided subjects into quartiles based on improvement in fitness, and examined whether these groups differed in terms of risk factors. Associations between changes in fitness and in cardiovascular risk factors were further tested using Pearson correlations. Significant heterogeneity was apparent in the improvement of fitness and individual risk factors, with nonresponder rates of 17% for fitness, 44% for body mass index, 33% for mean arterial pressure, 49% for total cholesterol, and 49% for high-density lipoprotein cholesterol. Neither the number, nor the magnitude, of change in cardiovascular risk factors differed significantly between quartiles of fitness change. Changes in fitness were not correlated with changes in cardiovascular risk factors (all P > 0.05). Our data suggest that significant heterogeneity exists in changes in peak oxygen uptake after training, while improvement in fitness did not relate to improvement in cardiovascular risk factors. In subjects with increased cardiovascular risk, improvements in fitness are not obligatory for training-induced improvements in cardiovascular risk factors.
Scepsis over proef om stadslucht te zuiveren
Molen, Michiel van der - \ 2017
Er zat sinds 1957 nog nooit zo veel vis in de Noordzee
Hintzen, Niels - \ 2017
De visserman wordt niet gehoord
Steins, Nathalie - \ 2016

Tot hun woede mogen vissers sinds begin dit jaar hun bijvangst niet langer overboord zetten. Het verplicht aan land brengen kost de sector 25 miljoen euro. En de effecten? „Dat weet niemand.”

Low-phosphate induction of plastidal stromules is dependent on strigolactones but not on the canonical strigolactone signaling component MAX2
Vismans, Gilles ; Meer, Tom van der; Langevoort, Olivier ; Schreuder, Marielle ; Bouwmeester, Harro ; Peisker, Helga ; Dörman, Peter ; Ketelaar, Tijs ; Krol, Sander van der - \ 2016
Plant Physiology 172 (2016)4. - ISSN 0032-0889 - p. 2235 - 2244.

Stromules are highly dynamic protrusions of the plastids in plants. Several factors, such as drought and light conditions, influence the stromule frequency (SF) in a positive or negative way. A relatively recently discovered class of plant hormones are the strigolactones; strigolactones inhibit branching of the shoots and promote beneficial interactions between roots and arbuscular mycorrhizal fungi. Here, we investigate the link between the formation of stromules and strigolactones. This research shows a strong link between strigolactones and the formation of stromules: SF correlates with strigolactone levels in the wild type and strigolactone mutants (max2-1 max3-9), and SF is stimulated by strigolactone GR24 and reduced by strigolactone inhibitor D2.

Balance of RNA sequence requirement and NS3/NS3a expression of segment 10 of orbiviruses
Feenstra, Femke ; Gennip, René G.P. Van; Schreuder, Myrte ; Rijn, Piet A. van - \ 2016
Journal of General Virology 97 (2016)2. - ISSN 0022-1317 - p. 411 - 421.

Orbiviruses are insect-transmitted, non-enveloped viruses with a ten-segmented dsRNA genome of which the bluetongue virus (BTV) is the prototype. Viral non-structural protein NS3/NS3a is encoded by genome segment 10 (Seg-10), and is involved in different virus release mechanisms. This protein induces specific release via membrane disruptions and budding in both insect and mammalian cells, but also the cytopathogenic release that is only seen in mammalian cells. NS3/NS3a is not essential for virus replication in vitro with BTV Seg-10 containing RNA elements essential for virus replication, even if protein is not expressed. Recently, new BTV serotypes with distinct NS3/NS3a sequence and cell tropism have been identified. Multiple studies have hinted at the importance of Seg-10 in orbivirus replication, but the exact prerequisites are still unknown. Here, more insight is obtained with regard to the needs for orbivirus Seg-10 and the balance between protein expression and RNA elements. Multiple silent mutations in the BTV NS3a ORF destabilized Seg-10, resulting in deletions and sequences originating from other viral segments being inserted, indicating strong selection at the level of RNA during replication in mammalian cells in vitro. The NS3a ORFs of other orbiviruses were successfully exchanged in BTV1 Seg-10, resulting in viable chimeric viruses. NS3/NS3a proteins in these chimeric viruses were generally functional in mammalian cells, but not in insect cells. NS3/NS3a of the novel BTV serotypes 25 and 26 affected virus release from Culicoides cells, which might be one of the reasons for their distinct cell tropism.

EIP-AGRI Focus Group; Protein Crops: final report
Schreuder, R. ; Visser, C.L.M. de - \ 2014
EIP-AGRI - 49
organische meststoffen - organisch bodemmateriaal - middellandse-zeegebied - innovaties - duurzaamheid (sustainability) - bodemvruchtbaarheid - peulvruchten - akkerbouw - kennisoverdracht - teeltsystemen - organic fertilizers - soil organic matter - mediterranean region - innovations - sustainability - soil fertility - grain legumes - arable farming - knowledge transfer - cropping systems
This report is the result of the EIP-AGRI Focus Group (FG) on Soil organic matter (SOM) content in Mediterranean regions, which was launched under the European Innovation Partnership Agricultural Productivity and Sustainability (EIP-AGRI). The Focus Group brought together 19 experts with different backgrounds and experiences to make recommendations on transferable innovative solutions for the purpose of improving soil organic matter content in the Mediterranean region in a cost-effective way while securing soil functionality and soil fertility in the specific context of Mediterranean regions
The EU's dependency on soya bean import for the animal feed industry and potential for EU produced alternatives
Visser, C.L.M. de; Schreuder, R. ; Stoddard, F. - \ 2014
OCL Oilseeds and Fats, Crops and Lipids 21 (2014)4. - ISSN 2257-6614 - 8 p.
The European Innovation Partnership Agri has set up a consultation process involving 20 experts from 11 EU countries to discuss the potential of a substantial increase in protein crop production in the EU. The dependency of Europe on soya bean meal imports and the associated drivers are described and underline the need for change. The EIP Agri process resulted in the assessment of the present-day yield gap of protein crops using an approach based on the market values of the protein, starch and plant oil components. Oil-based protein crops seemed to be overall better positioned than starch based protein crops because the price of oil levels is higher than that of starch. Alfalfa was identified as being interesting for regions where drying cost are low. The process also resulted in the identification of opportunities and constraints to be encountered by the innovation process, combining the knowledge and physical infrastructure, market structure, co-operation and interaction and the influence of culturally determined values and beliefs. Therefore, the recommendation is to develop a comprehensive approach to meet the challenge of substantially increasing the EU’s protein crop production
Exploring salutogenic mechanisms of an outdoor experiential learning programme on youth care farms in the Netherlands: untapped potential?
Schreuder, E. ; Rijnders, M. ; Vaandrager, L. ; Hassink, J. ; Enders-Slegers, M.J. ; Kennedy, L. - \ 2014
International Journal of Adolescence and Youth 19 (2014)2. - ISSN 0267-3843 - p. 139 - 152.
This study explored how (learning) experiences offered through outdoor experiential programmes, particularly the youth care farm approach, may (or may not) enhance young peoples' ability to recognise and then utilise available resources for personal growth, protection and health promotion. A total of 11 youngsters were asked to look back on their half-year stay on a care farm in the Netherlands, by using semi-structured interviews to elicit their experiences from a salutogenic perspective. Analysis revealed that several resources (and the interaction of these resources) on the youth care farm worked well for the youngsters; contributed to their personal development and to their sense of coherence: the feeling that the world is or can be meaningful, comprehensible and manageable, associated with positive outcome in endeavours linked to improving health and well-being. In general, the attitude of the farmer, working with animals, the informal atmosphere and being temporarily cut-off from the former environment were elements most positively highlighted by the youngsters. The farm environment was mentioned as calming, however, as structuring as well. The strength of the programme as an experiential learning opportunity appears to be the diversity and richness of resources (and stressors!) available to the participants. This creates various opportunities for learning: making sense, interpreting and giving meaning to resources and stressors. Further research into the impact of this kind of programmes, compared to more ‘traditional’ programmes, especially on the ability of youngsters to use resources to finish school, find employment and develop better relationships with their parents is recommended.
Integrated land management in the Netherlands
Corporaal, A. ; Schreuder, A. ; Stortelder, A.H.F. - \ 2013
In: Economy and ecology of heathlands / Diemont, W.H., Heijman, W.J.M., Siepel, H., Zeist : KNNV Publishing - ISBN 9789050114615 - p. 406 - 408.
The elephant interferon gamma assay: a contribution to diagnosis of tuberculosis in elephants
Angkawanish, T. ; Morar, D. ; Kooten, P.J. ; Bontekoning, I. ; Schreuder, J. ; Maas, M. ; Wajjwalku, W. ; Sirimalaisuwan, A. ; Michel, A.L. ; Tijhaar, E. ; Rutten, V.P.M.G. - \ 2013
Transboundary and Emerging Diseases 60 (2013)S1. - ISSN 1865-1674 - p. 53 - 59.
captive asian elephants - mycobacterium-tuberculosis - bovine tuberculosis - ifn-gamma - infection - transmission - responses - antigens - african - disease
Mycobacterium tuberculosis (M. tb) has been shown to be the main causative agent of tuberculosis in elephants worldwide. M. tb may be transmitted from infected humans to other species including elephants and vice versa, in case of prolonged intensive contact. An accurate diagnostic approach covering all phases of the infection in elephants is required. As M. tb is an intracellular pathogen and cell-mediated immune (CMI) responses are elicited early after infection, the skin test is the CMI assay of choice in humans and cattle. However, this test is not applicable in elephants. The interferon gamma (IFN-) assay is considered a good alternative for the skin test in general, validated for use in cattle and humans. This study was aimed at development of an IFN- assay applicable for diagnosis of tuberculosis in elephants. Recombinant elephant IFN- (rEpIFN-) produced in eukaryotic cells was used to immunize mice and generate the monoclonal antibodies. Hybridomas were screened for IFN--specific monoclonal antibody production and subcloned, and antibodies were isotyped and affinity purified. Western blot confirmed recognition of the rEpIFN-. The optimal combination of capture and detection antibodies selected was able to detect rEpIFN- in concentrations as low as 1 pg/ml. The assay was shown to be able to detect the native elephant IFN-, elicited in positive-control cultures (pokeweed mitogen (PWM), phorbol myristate acetate plus ionomycin (PMA/I)) of both Asian and African elephant whole-blood cultures (WBC). Preliminary data were generated using WBC from non-infected elephants, a M. tb infection-suspected elephant and a culture-confirmed M. tb-infected elephant. The latter showed measurable production of IFN- after stimulation with ESAT6/CFP10 PPDB and PPDA in concentration ranges as elicited in WBC by Mycobacterium tuberculosis complex (MTBC)-specific antigens in other species. Hence, the IFN- assay presented potential as a diagnostic tool for the detection of elephant tuberculosis. Validation of the assay will require its application in large populations of non-infected and infected elephants.
Towards establishing a rhinoceros-specific interferon-gamma (IFN-y) assay for diagnosis of tuberculosis
Morar, D. ; Schreuder, J. ; Meny, M. ; Kooten, P.J. ; Tijhaar, E. ; Michel, A.L. ; Rutten, V.P.M.G. - \ 2013
Transboundary and Emerging Diseases 60 (2013)s1. - ISSN 1865-1674 - p. 60 - 66.
mycobacterium-bovis bcg - kruger-national-park - african buffalo - cattle - infection - esat-6 - tests - cocktails - antigens - cfp-10
Mycobacterium bovis is the causal agent of bovine tuberculosis (BTB), with a diverse host range, extending from livestock to domestic and captive wild animals as well as free-ranging wildlife species. In South Africa, BTB is endemic in the Kruger National Park (KNP) and the Hluluwe iMfolozi National Park (HiP), where the high prevalence of M. bovis infections in buffalo herds has led to infection of a number of wildlife species. This has raised concerns about the spillover into the rhinoceros population, a species known to be susceptible to both M. bovis and Mycobacterium tuberculosis, jeopardizing breeding and relocation projects that serve to conserve and protect this species. In view of the advantages of the interferon-gamma (IFN-¿) assay in the diagnosis of BTB in a variety of species worldwide, such an assay has been developed for rhinoceroses by Morar and co-workers in 2007. In this study, this assay was optimized using recombinant eukaryotic rhinoceros IFN-¿ and the lower detection limit was calculated to be 0.5 ng/ml. Subsequently, assessing the detection of native rhinoceros IFN-¿ protein in whole-blood samples revealed stimulation with each of the mitogens: pokeweed (PWM), phytohaemagglutinin (PHA) & phorbol 12-myristate 13-acetate and calcium ionophore (PMA/CaI), though most prominently with the latter two. In addition, samples collected from 52 clinically healthy rhinoceroses, of presumed negative BTB status, from two different areas in South Africa were used to determine the cut-off value for a negative test result. This was calculated to be 0.10 (OD490 nm) and as determined in this study is a preliminary recommendation based on IFN-¿ responses observed in samples from BTB-free rhinoceroses only.
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