Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Transitioning from Manual to Automated Software Regression Testing: Experience from the Banking Domain
Akin, Abdurrahman ; Senturk, Serafettin ; Garousi, Vahid - \ 2019
In: Proceedings - 25th Asia-Pacific Software Engineering Conference, APSEC 2018. - IEEE computer society - ISBN 9781728119700 - p. 591 - 597.
experience report - mobile software - regression testing - Software testing - test automation

Regression testing is needed when a software or the environment hosting that software changes. Motivated by a real-world industrial need in the context of a large financial (banking) corporation in Turkey, the authors and their colleagues developed and introduced an automated regression testing infrastructure for automated testing of one of the main mobile applications of the company. Before this project, regression testing was conducted manually which incurred a lot of costs and was by nature subjective. We report in this paper our experience in 'transitioning' from manual to automated regression testing, and in developing and introducing a set of large automated test suites (more than 16 KLOC in total), using best practices in state-of-the art and -practice, and to report its observed benefits by conducting cost-benefit analysis. The project was conducted based on the principles of case-study and 'action research' in which the real industrial needs drove the research. Among the best practices that we used are the followings: (1) modularity in test code, (2) creating test-specific libraries, and (3) separating test data from test logic. By serving as a success story and experience report in development and introduction of automated test suites in an industrial setting, this paper adds to the body of evidence in this area and it aims at sharing both technical (e.g., using automated test patterns) and process aspects (e.g., test process improvement) from our project with other practitioners and researchers.

Effects of black hoof medicinal mushroom, phellinus linteus (Agaricomycetes), polysaccharide extract in streptozotocin-induced diabetic rats
Yamaç, Mustafa ; Zeytinoğlu, Melih ; Şentürk, Hakan ; Kartkaya, Kazim ; Kanbak, Göngör ; Bayramoğlu, Gökhan ; Oğlakci, Ayşegül ; Griensven, Leo J.L.D. van - \ 2016
International Journal of Medicinal Mushrooms 18 (2016)4. - ISSN 1521-9437 - p. 301 - 311.
Antidiabetic activity - Medicinal mushrooms - Phellinus linteus - Polysaccharide - Rat

In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)–induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-to-lysosomal ratio of cathepsin B and L, DNA fragmentation levels), ordinary histological and immuno-his-tochemical investigation parameters. Following oral administration of PLE after STZ application, the serum glucose concentration significantly decreased up to 41.13% compared with the control group (P <0.05). The hypoglycemic potential of the PLE was further supported by an increase of insulin secretion in the islets of Langerhans. In addition, the number of cells in Langerhans islets increased by 45.89% when PLE was given after STZ application. On the other hand, the use of PLE before oxidative stress could not prevent the onset of diabetes. This is, to our knowledge, the first study of the effect of application time of orally administered Ph. linteus hot water extract on STZ-induced diabetes.

Consumption of Coprinus comatus polysaccharide extract causes recovery of alcoholic liver damage in rats
Ozalp, F.O. ; Canbek, M. ; Yamac, M. ; Kanbak, G. ; Griensven, L.J.L.D. van; Uyanoglu, M. ; Senturk, H. ; Karlkava, K. ; Oglakci, A. - \ 2014
Pharmaceutical biology 52 (2014)8. - ISSN 1388-0209 - p. 994 - 1002.
induced diabetic-rats - ethanol-induced apoptosis - induced oxidative stress - mouse-liver - caspase-3 activation - injury - disease - lipopolysaccharide - neurodegeneration - hepatotoxicity
Excess use of alcohol is known to be associated with liver diseases such as fatty liver, alcoholic hepatitis, and cirrhosis. Various practices may be applied to prevent or treat the damage caused by chronic alcoholism. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) is a macrofungus that has been reported to aid the recovery of murine livers damaged by benzopyrene.
Effects of polysaccharide from fruiting bodies of Agaricus bisporus, Agaricus brasiliensis, and Phenllinus linteus on alcoholic liver injury
Uyanoglu, M. ; Canbek, M. ; Griensven, L.J.L.D. van; Yamac, M. ; Senturk, H. ; Kartkaya, K. ; Oglakci, A. ; Turgak, O. ; Kanbak, G. - \ 2014
International Journal of Food Sciences and Nutrition 65 (2014)4. - ISSN 0963-7486 - p. 482 - 488.
permeability transition pore - ethanol-induced apoptosis - rats - disease - mushrooms - diets
In the present study, the curative effects of crude polysaccharides (PSs) from mushrooms on the symptoms of alcoholic liver injury were investigated. PSs from Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus fruiting bodies were administered by gavage at levels of 100¿mg per kg body weight per day for 7¿d after the onset of the disease. The caspase-3 activity, mitochondrial membrane potential, mitochondrial outer membrane integrity of the liver tissues of sacrificed rats, and the serum alanine aminotransferase (ALT) levels were determined. In addition, light and transmission electron microscope (TEM) studies were performed for histopathological and cytological evaluations on liver sections. PSs from A. brasiliensis decreased ALT level and mitochondrial membrane potential and increased the outer membrane integrity; microscopic examinations also revealed normal hepatocytes and tissue. On the basis of our data, it can be argued that crude PSs from Agaricus brasiliensis have therapeutic potential for alcoholic liver injury.
Pancreas Protective Effect of Button Mushroom Agaricus bisporus (JE Lange) Imbach (Agaricomycetidae) Extract on Rats with Streptozotocin-Induced Dia betes
Yamac, M. ; Kanbak, G. ; Zeytinoglu, M. ; Senturk, H. ; Bayramoglu, G. ; Dokumacioglu, A. ; Griensven, L.J.L.D. van - \ 2010
International Journal of Medicinal Mushrooms 12 (2010)4. - ISSN 1521-9437 - p. 379 - 389.
antioxidant defense - diabetes-mellitus - oxidative stress - glucose toxicity - ergothioneine - prevalence - tissue - cells
In the present study we describe the effects of hot water extract of the culinary-medicinal button mushroom, Agaricus bisporus, on the symptoms of streptozotocin-induced diabetes in Sprague Dawley rats. A. bisporus extract at the doses of 0, 100, 200, and 400 mg/kg body weight (bw) per day were orally applied to streptozotocin-induced diabetic rats for a period of 7 days after the onset of the diabetes. Food and water intake and body weight were recorded daily. Upon sacrifice, histological studies were performed on pancreas tissues, and biochemical parameters such as glucose, insulin superoxide dismutase, malondialdehyde and catalase were measured of all experimental groups. The serum glucose levels significantly decreased after oral administration at the dose of 400 mg/kg bw per day by 29.68% with A. bisporus extract. Furthermore, the serum insulin levels in the streptozotocin-induced diabetic rats were increased to 78.50% at the extract dose of 400 mg/kg bw per day. Also, catalase activities and malondialdehyde levels decreased to values slightly above the normal animal control. The most obvious and surprising change was, however, the increase in cellularity of the Langerhans islets of the pancreas and their apparent repopulation with beta cells. We conclude that the oral application of high doses of A. bisporus extract may result in decreased severity of streptozotocin-induced diabetes in rat.
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