Zoetwatervoorziening in Nederland : aangescherpte landelijke knelpuntenanalyse 21e eeuw
Klijn, Frans ; Velzen, Emiel van; Maat, Judith ter; Hunink, Joachim ; Baarse, Gerrit ; Beumer, Victor ; Boderie, Pascal ; Buma, Jelle ; Delsman, Joost ; Hoogewoud, Jacco ; Hoogvliet, Marco ; Prinsen, Geert ; Bakel, Jan van; Mark, Rolien van der; Ek, Remco van; Sligte, Robin van; Verheij, Henk ; Zwolsman, Gert-Jan - \ 2012
Delft : Deltares - 229
Dit rapport gaat over de aanscherping van de knelpuntenanalyse die is uitgevoerd in de context van de landelijke zoetwaterverkenning.
Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice
Wei, H. ; Hu, C. ; Wang, M. ; Hoek, A.M. van den; Reijmers, T.H. ; Wopereis, S. ; Bouwman, J. ; Ramaker, R. ; Korthout, H.A.A.J. ; Vennik, M. ; Hankemeier, T. ; Havekes, L.M. ; Witkamp, R.F. ; Verheij, E.R. ; Xu, G. ; Greef, J. de - \ 2012
PLoS ONE 7 (2012)1. - ISSN 1932-6203
cholesteryl ester transfer - systems biology - apoe-asterisk-3-leiden.cetp mice - aggravates atherosclerosis - overweight patients - chinese medicine - weight-reduction - transfer protein - hdl-cholesterol - transgenic mice
Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. Methodology/Principal Findings: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49%, p <0.001), CETP levels (-31%, p
|SBW Wave overtopping and grass cover strength, Model developement
Steendam, G.J. ; Hoffmans, G. ; Bakker, J. ; Meer, J. van der; Frissel, J.Y. ; Paulissen, M.P.C.P. ; Verheij, H.J. - \ 2012
Delft : Deltares (1206016-007 ) - 139 p.
|Technisch rapport toetsen grasbekledingen op dijken
Meer, J. van der; Verheij, H. ; Hoffmans, G. ; Paulissen, M.P.C.P. ; Steendam, G.J. ; Hoven, A. van - \ 2012
Deltares - 123 p.
Jongerden, J.P. ; Verheij, J. - \ 2012
In: Social Relations in Ottoman Diyarbekir, 1870-1915 / Jongerden, J.P., Verheij, J., Leiden & Boston : Brill - ISBN 9789004225183 - p. 1 - 13.
|Social Relations in Ottoman Diyarbekir, 1870-1915
Jongerden, J.P. ; Verheij, J. - \ 2012
Leiden & Boston : Brill (Ottoman empire and its heritage vol. 51) - ISBN 9789004225183 - 368
osmaanse rijk - turkije - west-azië - geschiedenis - sociale structuur - etnische groepen - levensomstandigheden - ottoman empire - turkey - west asia - history - social structure - ethnic groups - living conditions
|Elite Encounters of a Violent Kind: Milli Ibrahim Pasa Ziya Gökalp and Political Struggle in Diyarbekir at the Turn of the 20th Century
Jongerden, J.P. - \ 2012
In: Social Relations in Ottoman Diyarbekir, 1870–1915 / Jongerden, J.P., Verheij, J., Leiden & Boston : Brill - ISBN 9789004225183 - p. 55 - 84.
Is a green residential environment better for health? if so, why?
Groenewegen, P.P. ; Berg, A.E. van den; Maas, J. ; Verheij, R.A. ; Vries, S. de - \ 2012
Annals of the Association Of American Geographers 102 (2012)5. - ISSN 0004-5608 - p. 996 - 1003.
natural-environment - physical-activity - possible mechanism - space - community - walking - inequalities - framework - exposure - urbanity
Over the past years our group has been working on a coherent research program on the relationships between greenspace and health. The main aims of this “Vitamin G” program (where G stands for green) were to empirically verify relationships between greenspace in residential areas and health and to gain insight into mechanisms explaining these relationships. In this article, we bring together key results of our program regarding the relevance of three possible mechanisms: stress reduction, physical activity, and social cohesion. The program consisted of three projects in which relationships between greenspace and health were studied at national, urban, and local scales. We used a mixed-method approach, including secondary analysis, survey data, observations, and an experiment. The results confirmed that quantity as well as quality of greenspace in residential areas were positively related to health. These relationships could be (partly) explained by the fact that residents of greener areas experienced less stress and more social cohesion. In general, residents of greener areas did not engage in more physical activity. The article concludes with a discussion of the practical implications of these findings and identification of areas that need more in-depth research
Unspecified gastroenteritis illness and deaths in the elderly associated with norovirus epidemics
Asten, L. van; Siebenga, J. ; Wijngaard, C. van den; Verheij, R. ; Vliet, H. van; Kretzschmar, M. ; Boshuizen, H.C. ; Pelt, W. van; Koopmans, M. - \ 2011
Epidemiology 22 (2011)3. - ISSN 1044-3983 - p. 336 - 343.
hospital admissions - united-states - rotavirus infection - nursing-homes - outbreaks - netherlands - disease - england - europe - virus
Background: New variant strains of norovirus have emerged worldwide in recent years, evolving by mutation much like influenza viruses. These strains have been associated with a notable increase in the number of annual norovirus outbreaks. However, the impact of such increased norovirus activity on morbidity and mortality is not clear because norovirus infection is rarely specifically registered. Methods: We studied trends of gastroenteritis with unspecified cause in medical registrations (ie, general practitioner [GP] visits, hospitalizations, and deaths) and their association with known temporal trends in norovirus outbreaks in the Netherlands. Using weekly counts in the elderly (aged 65+ years) from 1999 through 2006, we applied Poisson regression analyses adjusted for additional pathogens and seasonal trends (linear, sine, and cosine terms). Results: In the elderly, each notified norovirus outbreak was associated with an estimated 26 unspecified gastroenteritis GP visits (95% confidence interval = 17-34), 2.2 unspecified gastroenteritis hospitalizations (1.6-2.7), and 0.14 unspecified gastroenteritis deaths (0.08-0.21). For the heaviest norovirus season (2004-2005), these models attributed up to 3804 unspecified gastroenteritis GP visits, 318 unspecified gastroenteritis hospitalizations, and 21 unspecified gastroenteritis deaths to norovirus outbreaks among a total elderly population of 2.3 million. Discussion: The recent increase in norovirus outbreak activity is associated with increases of unspecified gastroenteritis morbidity and even deaths in the elderly. Norovirus should not be regarded as an infection with trivial health risks.
The influence of population characteristics on variation in general practice based morbidity estimations
Dungen, C. van den; Hoeymans, N. ; Boshuizen, H.C. ; Akker, M. van den; Biermans, M.C. ; Boven, K. van; Brouwer, H.J. ; Verheij, R.A. ; Waal, M.W. de; Schellevis, F.G. ; Westert, G.P. - \ 2011
BMC Public Health 11 (2011). - ISSN 1471-2458
multilevel logistic-regression - prevalence - disease - health
Background General practice based registration networks (GPRNs) provide information on morbidity rates in the population. Morbidity rate estimates from different GPRNs, however, reveal considerable, unexplained differences. We studied the range and variation in morbidity estimates, as well as the extent to which the differences in morbidity rates between general practices and networks change if socio-demographic characteristics of the listed patient populations are taken into account. Methods The variation in incidence and prevalence rates of thirteen diseases among six Dutch GPRNs and the influence of age, gender, socio economic status (SES), urbanization level, and ethnicity are analyzed using multilevel logistic regression analysis. Results are expressed in median odds ratios (MOR). Results We observed large differences in morbidity rate estimates both on the level of general practices as on the level of networks. The differences in SES, urbanization level and ethnicity distribution among the networks' practice populations are substantial. The variation in morbidity rate estimates among networks did not decrease after adjusting for these socio-demographic characteristics. Conclusion Socio-demographic characteristics of populations do not explain the differences in morbidity estimations among GPRNs
|Golfoverslag en sterkte binnentaluds van dijken
Adrichem, M.H.C. van; Akker, J.J.H. van den; Akkerman, G.J. ; Frissel, J.Y. ; Hendriks, R.F.A. ; Hoffmans, G. ; Hoven, A. van; Huiskes, H.P.J. ; Hummelink, E.W.J. ; Meer, J. van der; Melman, T.C.P. ; Paulissen, M.P.C.P. ; Steendam, G.J. ; Verheij, H. ; et al., - \ 2011
Delft : Deltares, Alterra Wageningen UR, Infram, Van der Meer Consulting (3 delen )
In de periode van 2007-2011 is in het kader van SBW Golfoverslag en Sterkte Grasbekledingen keihard gewerkt aan onderzoek naar het gedrag van grasbekledingen op dijken bij golfoverslag. In 2012 heeft het onderzoek geleidt [geleid] tot een Technisch Rapport Toetsen van Grasbekledingen op Dijken. Tussentijds zijn veel rapporten geschreven die in deze drie mappen zijn samengevoegd, om te dienen als naslagwerk. Het onderzoek is uitgevoerd door een projectgroep met vertegenwoordiging vanuit Deltares, Indram, Van der Meer Consulting en Alterra.
|Modelling the erosive impact of overtopping waves on grassed landward slopes of dikes and levees
Hoffmans, G. ; Verheij, H. ; Paulissen, M.P.C.P. ; Hoven, A. van; Meer, J. van der - \ 2011
|Erosion at transitions in landward slopes of dikes and levees due to wave overtopping
Verheij, H. ; Hoffmans, G. ; Hardeman, B. ; Paulissen, M.P.C.P. - \ 2010
- p. 1 - 2.
Green space as a buffer between stressful life events and health
Berg, A.E. van den; Maas, J. ; Verheij, R.A. ; Groenewegen, P.P. - \ 2010
Social Science and Medicine 70 (2010)8. - ISSN 0277-9536 - p. 1203 - 1210.
threatening experiences - multilevel analysis - physical-activity - environments - exposure - view - availability - restoration - settings - children
This study investigates whether the presence of green space can attenuate negative health impacts of stressful life events. Individual-level data on health and socio-demographic characteristics were drawn from a representative two-stage sample of 4529 Dutch respondents to the second Dutch National Survey of General Practice (DNSGP-2), conducted in 2000-2002. Health measures included: (1) the number of health complaints in the last 14 days; (2) perceived mental health (measured by the GHQ-12); and (3) a single item measure of perceived general health ranging from 'excellent' to 'poor'. Percentages of green space in a 1-km and 3-km radius around the home were derived from the 2001 National Land cover Classification database (LGN4). Data were analysed using multilevel regression analysis, with GP practices as the group-level units. All analyses were controlled for age, gender, income, education level, and level of urbanity. The results show that the relationships of stressful life events with number of health complaints and perceived general health were significantly moderated by amount of green space in a 3-km radius. Respondents with a high amount of green space in a 3-km radius were less affected by experiencing a stressful life event than respondents with a low amount of green space in this radius. The same pattern was observed for perceived mental health, although it was marginally significant. The moderating effects of green space were found only for green space within 3 km, and not for green space within 1 km of residents' homes, presumably because the 3-km indicator is more affected by the presence of larger areas of green space, that are supposed to sustain deeper forms of restoration. These results support the notion that green space can provide a buffer against the negative health impact of stressful life events
Effects of organically and conventionally produced feed on biomarkers of health in a chicken model
Huber, M. ; Vijver, L.P.L. van de; Parmentier, H.K. ; Savelkoul, H.F.J. ; Coulier, L. ; Wopereis, S. ; Verheij, E. ; Greef, J. de; Nierop, D. ; Hoogenboom, R.A.P. - \ 2010
The British journal of nutrition 103 (2010)5. - ISSN 0007-1145 - p. 663 - 676.
red-blood-cells - catch-up growth - antibody-responses - natural antibodies - immune-responses - lines - foods - metabolomics - systems - consequences
Consumers expect organic products to be healthier. However, limited research has been performed to study the effect of organic food on health. The present study aimed to identify biomarkers of health to enable future studies in human subjects. A feeding experiment was performed in two generations of three groups of chickens differing in immune responsiveness, which were fed identically composed feeds from either organic or conventional produce. The animals of the second generation were exposed to an immune challenge and sacrificed at 13 weeks of age. Feed and ingredients were analysed on macro- and micronutrients, i.e. vitamins, minerals, trace elements, heavy metals and microbes. The chickens were studied by general health and immune parameters, metabolomics, genomics and post-mortem evaluation. The organic and conventional feeds were comparable with respect to metabolisable energy. On average, the conventionally produced feeds had a 10 % higher protein content and some differences in micronutrients were observed. Although animals on both feeds were healthy, differences between the groups were found. The random control group of chickens fed conventional feed showed overall a higher weight gain during life span than the group on organic feed, although feed intake was mostly comparable. The animals on organic feed showed an enhanced immune reactivity, a stronger reaction to the immune challenge as well as a slightly stronger ‘catch-up growth’ after the challenge. Biomarkers for future research were identified in the parameters feed intake, body weight and growth rate, and in immunological, physiological and metabolic parameters, several of these differing most pronounced after the challenge
Morbidity is related to a green living environment
Maas, J. ; Verheij, R.A. ; Vries, S. de; Spreeuwenberg, P. ; Schellevis, F.G. ; Groenewegen, P.P. - \ 2009
Journal of Epidemiology and Community Health 63 (2009)12. - ISSN 0143-005X - p. 967 - 973.
urban-rural variations - selective migration - health - inequalities - preference - context - spaces - areas
Background: As a result of increasing urbanisation, people face the prospect of living in environments with few green spaces. There is increasing evidence for a positive relation between green space in people's living environment and self-reported indicators of physical and mental health. This study investigates whether physician-assessed morbidity is also related to green space in people's living environment. Methods: Morbidity data were derived from electronic medical records of 195 general practitioners in 96 Dutch practices, serving a population of 345 143 people. Morbidity was classified by the general practitioners according to the International Classification of Primary Care. The percentage of green space within a 1 km and 3 km radius around the postal code coordinates was derived from an existing database and was calculated for each household. Multilevel logistic regression analyses were performed, controlling for demographic and socioeconomic characteristics. Results: The annual prevalence rate of 15 of the 24 disease clusters was lower in living environments with more green space in a 1 km radius. The relation was strongest for anxiety disorder and depression. The relation was stronger for children and people with a lower socioeconomic status. Furthermore, the relation was strongest in slightly urban areas and not apparent in very strongly urban areas. Conclusion: This study indicates that the previously established relation between green space and a number of self-reported general indicators of physical and mental health can also be found for clusters of specific physician-assessed morbidity. The study stresses the importance of green space close to home for children and lower socioeconomic groups.
Is green space in the living environment associated with people's feelings of social safety?
Maas, J. ; Spreeuwenberg, P. ; Winsum-Westra, M. van; Verheij, R.A. ; Vries, S. de; Groenewegen, P.P. - \ 2009
Environment and Planning A 41 (2009)7. - ISSN 0308-518X - p. 1763 - 1777.
inner-city - built environment - perceived danger - womens fear - crime - urban - health - preference - settings - areas
The authors investigate whether the percentage of green space in people’s living environment affects their feelings of social safety positively or negatively. More specifically they investigate the extent to which this relationship varies between urban and rural areas, between groups in the community that can be identified as more or less vulnerable, and the extent to which different types of green space exert different influences. The study includes 83 736 Dutch citizens who were interviewed about their feelings of social safety. The percentage of green space in the living environment of each respondent was calculated, and data analysed by use of a three-level latent variable model, controlled for individual and environmental background characteristics. The analyses suggest that more green space in people’s living environment is associated with enhanced feelings of social safety—except in very strongly urban areas, where enclosed green spaces are associated with reduced feelings of social safety. Contrary to the common image of green space as a dangerous hiding place for criminal activity which causes feelings of insecurity, the results suggest that green space generally enhances feelings of social safety. The results also suggest, however, that green space in the most urban areas is a matter of concern with respect to social safety
|Doorbraakvrije dijken, Opzet doorbraakvije zeedijken en voorlopige conclusies sterkte binnentaluds bij golfoverslag
Meer, J.W. van der; Wouters, J. ; Steendam, G.J. ; Horst, W.L.A. ter; Akkerman, G.J. ; Hoven, A. van; Verheij, H.J. ; Frissel, J.Y. - \ 2008
Marknesse : Van der Meer Consulting - 47 p.
|Effect of organic and conventional feed on potential biomarkers of health in a chicken model
Huber, M.A.S. ; Vijver, L.P.L. van de; Vries, A. de; Nierop, D. ; Adriaansen-Tennekes, R. ; Parmentier, H.K. ; Savelkoul, H.F.J. ; Coulier, L. ; Verheij, E. ; Freidig, A. ; Greef, J. de; Hoogenboom, R. - \ 2008
|Transmission of highy pathogenic avian influenza virus (H5N1) in vaccinated and unvaccinated chicken
Katsma, W.E.A. ; Jong, M.C.M. de; Hakze-van der Honing, R.W. van der; Verheij, E. ; Poel, W.H.M. van der; Boven, R.M. van - \ 2006
Lelystad : Animal Sciences Group (Report / Animal Sciences Group 06/101839)