Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    The genomics of circadian timing in a wild bird, the great tit (Parus major)
    Laine, Veronika N. ; Atema, Els ; Vlaming, Priscilla ; Verhagen, Irene ; Mateman, Christa ; Ramakers, Jip J.C. ; Oers, Kees van; Spoelstra, Kamiel ; Visser, Marcel E. - \ 2019
    Frontiers in Ecology and Evolution 7 (2019). - ISSN 2296-701X
    Circadian rhythm - Clock - GWAS - Heritability - Parus major

    Circadian rhythms are ubiquitous among taxa and are essential for coping with recurrent daily events, leading to selection on the properties of the clock underlying these rhythms. To quantify this selection in the wild, we need, however, to phenotype wild individuals, which is difficult using the standard laboratory approach for which individuals need to be kept under constant conditions. To overcome this problem, we explored the possibility to link the variation in a key clock property, circadian period (Tau), to genetic variation. We measured Tau in 152 captive great tits (Parus major). We further linked Tau to two circadian phase markers, the onset of activity in the Light:Dark cycle, and the first onset in constant conditions (Dim:Dim), directly after entrainment. We did a genome-wide association study using a 650 k SNP chip, and we linked genetic polymorphisms of a set of 12 candidate genes, to Tau and the two circadian phase markers. In line with earlier studies, Tau was heritable (h2 = 0.48 ± 0.22). Despite this genetic variation, we did not find any significant associations at the genome-wide level with the measured traits and only one candidate gene showed association with onset of activity in the Light:Dark cycle. Identifying the genetic base of circadian timing for wild species thus remains challenging. Including alternative molecular methods such as epigenetics or transcriptomics could help to unravel the molecular basis of the biological clock in great tits.

    Lespakket groenbemesters
    Dijkshoorn-Dekker, M.W.C. ; Leeuwen-Haagsma, W.K. van; Hoek, H. ; Molendijk, L.P.G. ; Mommer, L. ; Os, G. ; Westerdijk, K. ; Langeloo, D. ; Kerkmeester, R. ; Vlaming, P. - \ 2019
    Wageningen : Groen Kennisnet
    Lesmateriaal dat opgenomen is in het Groen Kennisnet dossier Groenbemesters (WURKS-project). Er zijn casussen (verwerkingsopdrachten) gemaakt over bodemkwaliteit voor diverse grondsoorten (klei, zand) en sectoren (akkerbouw, melkveehouderij, gemengd) die voor zowel MBO- als HBO geschikt zijn. De casussen zijn als zodanig te gebruiken, maar kunnen ook ideeën geven voor het maken van eigen opdrachten.
    Genome-wide analysis identifies 12 loci influencing human reproductive behavior
    Barban, Nicola ; Jansen, Rick ; Vlaming, Ronald de; Vaez, Ahmad ; Mandemakers, Jornt J. ; Tropf, Felix C. ; Shen, Xia ; Wilson, James F. ; Chasman, Daniel I. ; Nolte, Ilja M. ; Tragante, Vinicius ; Laan, Sander W. van der; Perry, John R.B. ; Kong, Augustine ; Ahluwalia, Tarunveer S. ; Albrecht, Eva ; Yerges-Armstrong, Laura ; Atzmon, Gil ; Auro, Kirsi ; Ayers, Kristin ; Bakshi, Andrew ; Ben-Avraham, Danny ; Berger, Klaus ; Bergman, Aviv ; Bertram, Lars ; Bielak, Lawrence F. ; Bjornsdottir, Gyda ; Bonder, Marc Jan ; Broer, Linda ; Bui, Minh ; Barbieri, Caterina ; Cavadino, Alana ; Chavarro, Jorge E. ; Turman, Constance ; Concas, Maria Pina ; Cordell, Heather J. ; Davies, Gail ; Eibich, Peter ; Eriksson, Nicholas ; Esko, Tõnu ; Eriksson, Joel ; Falahi, Fahimeh ; Felix, Janine F. ; Fontana, Mark Alan ; Franke, Lude ; Gandin, Ilaria ; Gaskins, Audrey J. ; Gieger, Christian ; Gunderson, Erica P. ; Guo, Xiuqing ; Hayward, Caroline ; He, Chunyan ; Hofer, Edith ; Huang, Hongyan ; Joshi, Peter K. ; Kanoni, Stavroula ; Karlsson, Robert ; Kiechl, Stefan ; Kifley, Annette ; Kluttig, Alexander ; Kraft, Peter ; Lagou, Vasiliki ; Lecoeur, Cecile ; Lahti, Jari ; Li-Gao, Ruifang ; Lind, Penelope A. ; Liu, Tian ; Makalic, Enes ; Mamasoula, Crysovalanto ; Matteson, Lindsay ; Mbarek, Hamdi ; McArdle, Patrick F. ; McMahon, George ; Meddens, S.F.W. ; Mihailov, Evelin ; Miller, Mike ; Missmer, Stacey A. ; Monnereau, Claire ; Most, Peter J. van der; Myhre, Ronny ; Nalls, Mike A. ; Nutile, Teresa ; Kalafati, Ioanna Panagiota ; Porcu, Eleonora ; Prokopenko, Inga ; Rajan, Kumar B. ; Rich-Edwards, Janet ; Rietveld, Cornelius A. ; Robino, Antonietta ; Rose, Lynda M. ; Rueedi, Rico ; Ryan, Kathleen A. ; Saba, Yasaman ; Schmidt, Daniel ; Smith, Jennifer A. ; Stolk, Lisette ; Streeten, Elizabeth ; Tönjes, Anke ; Thorleifsson, Gudmar ; Ulivi, Sheila ; Wedenoja, Juho ; Wellmann, Juergen ; Willeit, Peter ; Yao, Jie ; Yengo, Loic ; Zhao, Jing Hua ; Zhao, Wei ; Zhernakova, Daria V. ; Amin, Najaf ; Andrews, Howard ; Balkau, Beverley ; Barzilai, Nir ; Bergmann, Sven ; Biino, Ginevra ; Bisgaard, Hans ; Bønnelykke, Klaus ; Boomsma, Dorret I. ; Buring, Julie E. ; Campbell, Harry ; Cappellani, Stefania ; Ciullo, Marina ; Cox, Simon R. ; Cucca, Francesco ; Toniolo, Daniela ; Davey-Smith, George ; Deary, Ian J. ; Dedoussis, George ; Deloukas, Panos ; Duijn, Cornelia M. van; Geus, Eco J.C. de; Eriksson, Johan G. ; Evans, Denis A. ; Faul, Jessica D. ; Sala, Cinzia Felicita ; Froguel, Philippe ; Gasparini, Paolo ; Girotto, Giorgia ; Grabe, Hans-Jörgen ; Greiser, Karin Halina ; Groenen, Patrick J.F. ; Haan, Hugoline G. de; Haerting, Johannes ; Harris, Tamara B. ; Heath, Andrew C. ; Heikkilä, Kauko ; Hofman, Albert ; Homuth, Georg ; Holliday, Elizabeth G. ; Hopper, John ; Hyppönen, Elina ; Jacobsson, Bo ; Jaddoe, Vincent W.V. ; Johannesson, Magnus ; Jugessur, Astanand ; Kähönen, Mika ; Kajantie, Eero ; Kardia, Sharon L.R. ; Keavney, Bernard ; Kolcic, Ivana ; Koponen, Päivikki ; Kovacs, Peter ; Kronenberg, Florian ; Kutalik, Zoltan ; Bianca, Martina la; Lachance, Genevieve ; Iacono, William G. ; Lai, Sandra ; Lehtimäki, Terho ; Liewald, David C. ; Lindgren, Cecilia M. ; Liu, Yongmei ; Luben, Robert ; Lucht, Michael ; Luoto, Riitta ; Magnus, Per ; Magnusson, Patrik K.E. ; Martin, Nicholas G. ; McGue, Matt ; McQuillan, Ruth ; Medland, Sarah E. ; Meisinger, Christa ; Mellström, Dan ; Metspalu, Andres ; Traglia, Michela ; Milani, Lili ; Mitchell, Paul ; Montgomery, Grant W. ; Mook-Kanamori, Dennis ; Mutsert, Renée de; Nohr, Ellen A. ; Ohlsson, Claes ; Olsen, Jørn ; Ong, Ken K. ; Paternoster, Lavinia ; Pattie, Alison ; Penninx, Brenda W.J.H. ; Perola, Markus ; Peyser, Patricia A. ; Pirastu, Mario ; Polasek, Ozren ; Power, Chris ; Kaprio, Jaakko ; Raffel, Leslie J. ; Räikkönen, Katri ; Raitakari, Olli ; Ridker, Paul M. ; Ring, Susan M. ; Roll, Kathryn ; Rudan, Igor ; Ruggiero, Daniela ; Rujescu, Dan ; Salomaa, Veikko ; Schlessinger, David ; Schmidt, Helena ; Schmidt, Reinhold ; Schupf, Nicole ; Smit, Johannes ; Sorice, Rossella ; Spector, Tim D. ; Starr, John M. ; Stöckl, Doris ; Strauch, Konstantin ; Stumvoll, Michael ; Swertz, Morris A. ; Thorsteinsdottir, Unnur ; Thurik, A.R. ; Timpson, Nicholas J. ; Tung, Joyce Y. ; Uitterlinden, André G. ; Vaccargiu, Simona ; Viikari, Jorma ; Vitart, Veronique ; Völzke, Henry ; Vollenweider, Peter ; Vuckovic, Dragana ; Waage, Johannes ; Wagner, Gert G. ; Wang, Jie Jin ; Wareham, Nicholas J. ; Weir, David R. ; Willemsen, Gonneke ; Willeit, Johann ; Wright, Alan F. ; Zondervan, Krina T. ; Stefansson, Kari ; Krueger, Robert F. ; Lee, James J. ; Benjamin, Daniel J. ; Cesarini, David ; Koellinger, Philipp D. ; Hoed, Marcel den; Snieder, Harold ; Mills, Melinda C. - \ 2016
    Nature Genetics 48 (2016)12. - ISSN 1061-4036 - p. 1462 - 1472.
    The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
    Field tests of dielectric sensors in a facility for studying salt tolerance of crops
    Straten, Gerrit Van; Vos, Arjen De; Vlaming, Rik ; Oosterbaan, Roland - \ 2016
    International Agricultural Engineering Journal 25 (2016)2. - ISSN 0858-2114 - p. 102 - 113.
    Calibration - Electrical conductivity - Irrigation - Salinity - Salt tolerance - Soil sensor - Volumetric water content

    Seven salinity levels ranging from 1.7 to 35 dS/m are applied to groups of eight fields each in a field facility for testing the salt tolerance of crops. Each of the 56 test fields is equipped with one or two dielectric sensors for soil volumetric water content (VWC) and bulk electric conductivity (ECb). Several models for calibrating the sensors in the laboratory were tested and parameterized. Overall, the root mean square error was in the range of 0.57-0.59 dS/m in terms of soil bulk EC. The models differed in their robustness against inversion to obtain pore water EC from measured bulk EC. The laboratory calibration formula overestimates the pore water EC at low EC (5 dS/m), and underestimates it at high EC (25 dS/m). In practice, calculated sensor pore water EC's in fields with the same salinity treatment differ among each other, showing the limitations of laboratory calibrations. However, in fields where pore water samples are available, a direct proportionality between pore water EC and sensor bulk EC suffices without correction for VWC in this well irrigated case. Moreover there is a good correlation between the low frequent EC time series of suction cup samples and the high frequent sensor readings. When used with care, sensors can give valuable information about the dynamics of soil conditions during crop salinity tolerance tests.

    Evaluatieonderzoek gezond ouder worden: inzicht in proces en effect op verschillende niveaus
    Heinrich, J. ; Haveman-Nies, A. ; Honigh-de Vlaming, R. ; Tol-van Vleuten, M. ; Groot, C.P.G.M. de; Veer, P. van 't - \ 2015
    PRIMET_registration_Ethiopia_1.1, technical description and manual : a decision support system for assessing pesticide risks in the tropics to man, environment and trade, for pesticide registration in Europe
    Wipfler, E.L. ; Adriaanse, P.I. ; Horst, M.M.S. ter; Vlaming, J. ; Brink, P.J. van den; Peeters, F.M. ; Deneer, J.W. ; Boesten, J.J.T.I. ; Groenwold, J.G. - \ 2014
    Wageningen : Alterra, Wageningen-UR (Alterra report 2573) - 133
    pesticiden - risicoschatting - ecologische risicoschatting - gezondheid - registratie - blootstelling - ethiopië - pesticides - risk assessment - ecological risk assessment - health - registration - exposure - ethiopia
    HAIR2014 software manual
    Kruijne, R. ; Vlaming, J. ; Deneer, J.W. ; Nousianen, R. ; Räsänen, K. - \ 2014
    Wageningen : Alterra, Wageningen-UR (Alterra-rapport 2544) - 65
    computer software - pesticiden - risico - richtlijnen (directives) - handboeken - europa - computer software - pesticides - risk - directives - handbooks - europe
    Goed Bezig: Resultaten van de Sociale Activering Strategie in de Regio Noord-Veluwe
    Honigh de Vlaming, R. ; Haveman-Nies, A. ; Pieterse, C.M.J. ; Ploeg, B. van der; Renes, R.J. - \ 2014
    Tijdschrift voor Gezondheidswetenschappen 92 (2014)8. - ISSN 1388-7491 - p. 325 - 333.
    De gemeenten in de Noord-Veluwe werken aan preventie van overgewicht en overmatig alcoholgebruik bij kinderen binnen het programma Goed Bezig. Onderdeel hiervan is de Sociale Activering Strategie welke als doel heeft burgers en ondernemers te stimuleren en activeren tot een gemeenschappelijke verantwoordelijkheid voor gezonde leefgewoonten van jongeren van 4-16 jaar. Met een proces- en effectevaluatie is het resultaat van de Sociale Activering Strategie op het aantal gerealiseerde initiatieven en het aantal deelnemers, de participatiebereidheid van ouders en het leefstijlgedrag van jongeren onderzocht. Voor de effectevaluatie is gebruik gemaakt van een quasi-experimentele studieopzet met een interventie- en controlegroep en een voor- en nameting. De studiepopulatie betrof ouders van kinderen in de leeftijd van 4-16 jaar (n=192). Voor de procesevaluatie zijn logboeken gebruikt. De Sociale Activering Strategie is erin geslaagd om met name jonge kinderen te laten deelnemen aan leefstijlactiviteiten, welke zeer positief werden gewaardeerd. Ondanks het feit dat het aantal volwassenen dat is bereikt en een actieve bijdrage heeft geleverd aan de activiteiten beperkt was, zijn succesvolle bewonersinitiatieven gerealiseerd. De positieve verandering in het beweeggedrag van jongeren van wie de ouders actief betrokken zijn geweest, wijst erop dat een groeiende participatiebereidheid van ouders kan leiden tot een positieve gedragsverandering bij jongeren na een aantal jaren.
    Determinants of Trends in Loneliness Among Dutch Older People Over the Period 2005-2010
    Honigh-de Vlaming, R. ; Haveman-Nies, A. ; Bos-Oude Groeniger, I. ; Groot, C.P.G.M. de; Veer, P. van 't - \ 2014
    Journal of Aging and Health 26 (2014)3. - ISSN 0898-2643 - p. 422 - 440.
    adult loneliness - social support - risk-factors - later life - age - population - predictors - networks - health - model
    Objective: This study aims to investigate the influence of socio-demographic, health, and municipal characteristics on trends in loneliness among community-dwelling elderly people. Method: Data were gathered from 4,868 and 4,773 non-institutionalized elderly people aged 65 years and above in a health survey in 2005 and 2010, respectively. Crude and adjusted multilevel models were analyzed to study the independent associations of study year and socio-demographic, health, and municipal characteristics with loneliness. Results: Overall and across municipalities, loneliness estimates did not significantly differ between 2005 and 2010. However, among the sub-group with activity limitations, loneliness was higher in 2010 compared with 2005. Discussion: This study indicates a constant trend in loneliness in the total population and across sub-groups with the exception of participants with one or more activity limitations, where loneliness increased. Individual socio-demographic and health characteristics were explanatory factors for variation in loneliness over time, whereas municipal characteristics were not.
    Loneliness literacy scale; development and evaluation of an early indicator for loneliness prevention
    Vlaming, R. de; Haveman-Nies, A. ; Bos-Oude Groeniger, I. ; Hooft Van Huysduynen, E.J.C. ; Groot, C.P.G.M. de; Veer, P. van 't - \ 2014
    Social Indicators Research 116 (2014)3. - ISSN 0303-8300 - p. 989 - 1001.
    social-isolation - older-people - health-promotion - public-health - interventions - adults
    To develop and evaluate the Loneliness Literacy Scale for the assessment of short-term outcomes of a loneliness prevention programme among Dutch elderly persons. Scale development was based on evidence from literature and experiences from local stakeholders and representatives of the target group. The scale was pre-tested among 303 elderly persons aged 65 years and over. Principal component analysis and internal consistency analysis were used to affirm the scale structure, reduce the number of items and assess the reliability of the constructs. Linear regression analysis was conducted to evaluate the association between the literacy constructs and loneliness. The four constructs “motivation”, “self-efficacy”, “perceived social support” and “subjective norm” derived from principal component analysis captured 56 % of the original variance. Cronbach’s coefficient a was above 0.7 for each construct. The constructs “self-efficacy” and “perceived social support” were positively and “subjective norm” was negatively associated with loneliness. To our knowledge this is the first study developing a short-term indicator for loneliness prevention. The indicator contributes to the need of evaluating public health interventions more close to the intervention activities.
    Effect evaluation of a two-year complex intervention to reduce loneliness in non-institutionalised elderly Dutch people
    Honigh-de Vlaming, R. ; Haveman-Nies, A. ; Heinrich, J. ; Veer, P. van 't; Groot, C.P.G.M. de - \ 2013
    BMC Public Health 13 (2013). - ISSN 1471-2458
    friendship enrichment program - older-adult loneliness - social-isolation - health-promotion - risk-factors - support - metaanalysis - depression - design - women
    Background: Public health policy calls for intervention programmes to reduce loneliness in the ageing population. So far, numerous loneliness interventions have been developed, with effectiveness demonstrated for few of these interventions. The loneliness intervention described in this manuscript distinguishes itself from others by including multiple intervention components and targeting individuals and their environment. Intervention components included a mass media campaign, information meetings, psychosocial group courses, social activities organised by neighbours, and training of intermediaries. The aim of this manuscript is to study the effects of this integrated approach on initial and long-term outcomes. Methods: A quasi-experimental pre-test post-test intervention study was conducted among non-institutionalised elderly people aged 65 years and over to evaluate the effectiveness of the intervention by comparing the intervention community and the control community. Data on outputs, initial and long-term outcomes, and the overall goal were collected by self-administered questionnaires. Data of 858 elderly people were available for the analyses. To assess the effect linear regression analyses with adjustments for age, gender, church attendance, and mental health were used. In addition, the process evaluation provided information about the reach of the intervention components. Results: After two years, 39% of the elderly people were familiar with the intervention programme. The intervention group scored more favourably than the control group on three subscales of the initial outcome, motivation (-4.4%, 95% CI-8.3-0.7), perceived social support (-8.2%, 95% CI-13.6-2.4), and subjective norm (-11.5%, 95% CI-17.4-5.4). However, no overall effects were observed for the long-term outcome, social support, and overall goal, loneliness. Conclusions: Two years after its initiation the reach of the intervention programme was modest. Though no effect of the complex intervention was found on social support and loneliness, more favourable scores on loneliness literacy subscales were induced.
    Acceptability of the components of a loneliness intervention among elderly Dutch people: a qualitative study
    Honigh-de Vlaming, R. ; Haveman-Nies, A. ; Ziylan, C. ; Renes, R.J. - \ 2013
    American Journal of Health Education 44 (2013)3. - ISSN 1932-5037 - p. 136 - 145.
    Healthy Ageing: prevention of loneliness among elderly people : evaluation of a complex intervention in public health practice
    Honigh - de Vlaming, R. - \ 2013
    Wageningen University. Promotor(en): Lisette de Groot; Pieter van 't Veer, co-promotor(en): Annemien Haveman-Nies. - S.l. : s.n. - ISBN 9789461735041 - 214
    ouderen - verouderen - levensomstandigheden - sociale integratie - sociologie - interventie - volksgezondheid - nederland - elderly - aging - living conditions - social integration - sociology - intervention - public health - netherlands

    Introduction
    Concerns about the ageing population and formal responsibilities of local governments to promote social cohesion and to enhance participation of vulnerable groups in society placed loneliness prevention high on the local policy agenda of Dutch municipalities in the past decade. The study described in this thesis was part of the Healthy Ageing programme of the Academic Collaborative Centre AGORA and aimed to contribute to more effective, evidence-based and problem-oriented approaches to healthy ageing at the local level.

    Aim
    The general aim of this thesis was to evaluate the effectiveness of a local intervention project – called Healthy Ageing – targeting loneliness among non-institutionalised elderly people. Healthy Ageing consisted of five intervention components, namely, a mass media campaign, information meetings, psychosocial group courses, social activities organised by neighbours, Neighbours Connected, and training of intermediaries.

    Methods
    First, the influence of socio-demographic and health characteristics on changes in loneliness over time and municipal differences in the prevalence of loneliness were investigated. Data were gathered from 9,641 persons who participated in the Elderly Health Survey of the community health service, GGD Noord- en Oost- Gelderland (former GGD Gelre-IJssel), in 2005 or 2010. Second, the overall-effect of Healthy Ageing on the initial outcome loneliness literacy, intermediate outcome social support, and ultimate outcome loneliness was evaluated using a quasi-experimental pre-test post-test design, including an intervention and control community. Baseline and follow-up measurements, in 2008 and 2010 respectively, were available for 858 non-institutionalized elderly people. The Loneliness Literacy Scale was developed within the context of this thesis and was pre-tested in a separate study among 303 elderly persons who also participated in the quasi-experimental study. Finally, delivery, reach, and acceptance of the individual intervention components was studied in several satellite studies. Data were collected by different means, e.g. project records and surveys among participants. Furthermore, the acceptability of the mass media communication materials, information meetings, and psychosocial courses of Healthy Ageing was studied by in-depth interviews with 14 clients of the meal delivery service in the intervention community.



    Results
    Overall and across municipalities, average loneliness scores did not significantly differ between 2005 and 2010. However, among the subgroup with mobility disabilities, loneliness was significantly higher in 2010. Furthermore, mobility disabilities and marital status were the most important factors explaining differences between municipalities. With regard to the evaluation of Healthy Ageing, the satellite studies showed that the reach and intensity of the intervention components were modest. Furthermore, from the interviews it appeared that the mass media communication materials were not successful in attracting attention because interviewees did not expect health information from these communication channels, the perceived personal relevance of the message was low, and the presentation was not attractive. Moreover, the content of the intervention components was not well received because the objectives and intervention components did not connect well with the priority group’s daily life. In addition, it appeared from the quasi-experimental study that 39% of the study participants from the intervention community was familiar with Healthy Ageing at follow-up. Overall, the intervention group scored more favourably on the loneliness literacy subscales, motivation (4.4%), perceived social support (8.2%), and subjective norm (11.5%) than the control group. However, no overall effects were observed for the intermediate and ultimate outcomes, total social support and loneliness after two years.

    Conclusion
    Given the modest overall intervention exposure, the effect of Healthy Ageing on the loneliness literacy subscale, motivation, is plausible, whereas on the subscales, perceived social support and subjective norm, probable, and on the subscale, self-efficacy, unlikely. Furthermore, whether the initial effects will carry forward to the intermediate and ultimate outcomes needs to be confirmed. The modest effects of Healthy Ageing can partly be explained by the challenges on organisational level which delayed and suppressed project implementation. Furthermore, the project might have benefited from a more systematic approach in order to ensure better alignment between the intervention components and formulated objectives. Finally, target group differentiation is highly recommended. This evaluation of Healthy Ageing illustrates how researchers can cope with the evaluation challenges of complex interventions which cannot be fully controlled. In turn, this provides valuable lessons for the development of intervention programmes and evaluation designs in public health practice.

    Lespakket Geïntegreerde Gewasbescherming
    Os, G.J. van; Vlaming, P. ; Hendrix, W. ; Janssen, H. - \ 2012
    Wageningen UR en de AOC-Raad
    De geleerde lessen uit het AGORA programma Gezond Ouder Worden I
    Lezwijn, J. ; Vlaming, R. de; Haveman-Nies, A. ; Coenen, I. - \ 2012
    Tijdschrift voor Gerontologie en Geriatrie 43 (2012). - ISSN 0167-9228 - 1 p.
    Loneliness health literacy scale: an early indicator for loneliness prevention
    Groot, C.P.G.M. de; Vlaming, R. de; Haveman-Nies, A. ; Hooft Van Huysduynen, E.J.C. ; Oude Groeniger, I. ; Veer, P. van 't - \ 2011
    Aging clinical and experimental research 23 (2011). - ISSN 1594-0667 - p. 264 - 264.
    Lespakketten plantgezondheid
    Os, G.J. van; Vlaming, P. ; Looman, B.H.M. - \ 2011
    Lespakketten plantgezondheid
    Os, G.J. van; Vlaming, P. ; Looman, B.H.M. - \ 2011
    Hair 2010 Documentation: Calculating risk indicators related to agricultural use of pesticides within the European Union
    Kruijne, R. ; Deneer, J.W. ; Lahr, J. ; Vlaming, J. - \ 2011
    Wageningen : Alterra (Alterra-report 2113.1) - 205
    pesticiden - risicofactoren - berekening - databanken - modellen - waterorganismen - bodem - grondwater - vogels - zoogdieren - beleid - gewassen - europese unie - pesticides - risk factors - calculation - databases - models - aquatic organisms - soil - groundwater - birds - mammals - policy - crops - european union
    The HAIR instrument calculates risk indicators related to the agricultural use of pesticides in EU Member States. HAIR combines databases and models for calculating potential environmental environmental effects expressed by the exposure toxicity ratio.
    HAIR2010 software manual
    Vlaming, J. ; Kruijne, R. ; Groenwold, J.G. - \ 2011
    Wageningen : Alterra (Alterra-report 2113.2) - 66
    pesticiden - risicofactoren - berekening - computer software - beleid - europese unie - pesticides - risk factors - calculation - computer software - policy - european union
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