Entomological correlates of epidemiological impacts: how do we know it is working?


  • A.K. Githeko


Assuming that transgenesis of malaria vector populations is feasible, it will be necessary to carry out entomological, morbidity and mortality trials to measure the degree of efficacy of this new intervention strategy. Taking into consideration the necessity to maintain reproductive fitness of a transgenic mosquito, the best strategy would be to target the sporogonic cycle and/or reduce the anthropophilic feeding behaviour of the vectors. The former would impact on the entomological inoculation rate (EIR) whereas the latter would impact on vectorial capacity. A three-phase trial would be carried out to test safety, efficacy and impact on morbidity and mortality. After confirmation of safety and efficacy, phases two and three would involve largescale multiple site trials