Kinetics of plasma lysine after oral and parenteral administration to pigs.
AbstractDutch Landrace X Large White pigs 14 to 15 weeks old and about 45 kg were fed on low-protein diets (16.1%) and supplemented with lysine, orally, by slow or rapid jugular infusion or by slow portal/caval infusion in order to evaluate the bioavailability of lysine with type of treatment. Elimination rate after intravenous treatment had a half-life of 2.0+or-1.6 h (after bolus injection) or 3.7+or-1.9 h (after slow infusion). Absorption of an oral dose of lysine from the intestine (half-life of 3.6+or-0.9 h) was slower than elimination rate (half-life of 0.9+or-0.3 h). No significant liver first-pass effects could be detected and bioavailability of lysine after enteral intake was 82+or-6%. Analysis of plasma kinetics of amino acids may provide a valuable tool to evaluate bioavailability of dietary amino acids. (Abstract retrieved from CAB Abstracts by CABI’s permission)